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69478 Sigma-Aldrich

N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane

for GC derivatization

  • CAS Number 24589-78-4

  • Empirical Formula (Hill Notation) C6H12F3NOSi

  • Molecular Weight 199.25

  •  Beilstein Registry Number 1941550

  •  MDL number MFCD00000411

  •  PubChem Substance ID 329761687

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Chemical Synthesis, Derivatization Reagents, Derivatization Reagents GC,
grade   for GC derivatization
  for GC derivatization
InChI Key   MSPCIZMDDUQPGJ-UHFFFAOYSA-N
refractive index   n20/D 1.378

Description

Other Notes

Same product — same quality — now Sigma-Aldrich brand

Application

Addition of Trimethylchlorosilane aids in the derivatization of amides, secondary amines and hindered hydroxy groups. Most volatile of the TMS derivatives often elutes at the solvent front of the GC.

General description

Silylation can be performed by adding N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MTFA) during analysis of fluorometabolites via gas chromatography-mass spectrometry (GC-MS).

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 1993C 3 / PGIII
WGK Germany 
3
Flash Point(F) 
78.8 °F
Flash Point(C) 
26 °C

Documents

Certificate of Analysis

Protocols & Articles

Articles

Silylating Reagents for GC-MS Compatible Derivatives of NSAIDs

Human and veterinary pharmaceuticals are a group of “emerging” contaminants,1, 2 some of which are produced in increasingly large volumes every year. The amounts produced are reaching quantities simi...
Luis-Alberto Martin
AnalytiX Volume 10 Article 2
Keywords: Anti-inflammatory agents, Derivatizations, Environmental, Gas chromatography, Gas chromatography mass spectrometry, Mass spectrometry, Metabolites, Pesticides, Pharmaceutical, Silylations, Veterinary

Peer-Reviewed Papers
15

References

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