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69479 Sigma-Aldrich

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

for GC derivatization, ≥98.5%

Synonym: N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Applications, Biodiesel, Biodiesel: Testing for Glycerin/Glyceride Contamination,
grade   for GC derivatization
  for GC/MS (SIM)
  for GC/MS
vapor density   >1 (vs air)
vapor pressure   8.8 mmHg ( 27 °C)
InChI Key   MSPCIZMDDUQPGJ-UHFFFAOYSA-N
assay   ≥98.5% (GC)
  ≥98.5%
refractive index   n20/D 1.38(lit.)
  n20/D 1.380
bp   130-132 °C(lit.)
density   1.075 g/mL at 25 °C(lit.)
derivatization reagent for   Silylations
storage temp.   2-8°C

Description

Other Notes

Powerful silylating agent

Reagent for N-acetyl-N, trifluoroacetyl, trimethylsilyl, N-trimethylsilyl-N-trifluoroacetyl, and O-trimethylsilyl (TMS)

Application

MSTFA may be used in silylation procedure to detemine steroid hormones 17α-ethinylestradiol (EE2) and estrone using GC-MS. MSTFA along with Trimethylsilyl chloride (TMCS) in eithyl acetate, acetonitrile and dichloromethane solvents leads to formation of trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS) derivatives.

General description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a silylating reagent.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 1993C 3 / PGIII
WGK Germany 
3
RTECS 
AC9800000
Flash Point(F) 
78.8 °F
Flash Point(C) 
26 °C
Protocols & Articles

Articles

GC Analysis of Tetrahydrocannabinol (THC) and Carboxytetrahydrocannabinol (THCCOOH) in Surface Water on SLB®-5ms after SPME using 50/30 μm DVB/Carboxen/PDMS Fiber, On-Fiber Derivatization

From our library of Articles, Sigma-Aldrich presents GC Analysis of Tetrahydrocannabinol (THC) and Carboxytetrahydrocannabinol (THCCOOH) in Surface Water on SLB®-5ms after SPME using 50/30 μm DVB/Carboxen/PDMS Fiber, On-Fiber Derivatization
Keywords: Chromatography, Derivatizations, Environmental, Gas chromatography, Metabolites, Sample preparations, Separation, Solid phase microextractions

Improved Detection & Identification using MSTFA/MSTFA-d9 Derivatization - GC/MS Case Study of Amphetamine

The following was generated with the assistance of an outside source using Sigma-Aldrich products. Technical content was generated and provided by: Dieter Urbach, Bundeskriminalamt (BKA), KT 12 – Zen...
Keywords: Chromatography, Derivatizations, Gas chromatography, Gas chromatography mass spectrometry, Mass spectrometry, Phase transitions, Silylations

Silylating Reagents for GC-MS Compatible Derivatives of NSAIDs

Human and veterinary pharmaceuticals are a group of “emerging” contaminants,1, 2 some of which are produced in increasingly large volumes every year. The amounts produced are reaching quantities simi...
Luis-Alberto Martin
AnalytiX Volume 10 Article 2
Keywords: Anti-inflammatory agents, Derivatizations, Environmental, Gas chromatography, Gas chromatography mass spectrometry, Mass spectrometry, Metabolites, Pesticides, Pharmaceutical, Silylations, Veterinary

Peer-Reviewed Papers
15

References

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