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69824 Sigma-Aldrich

Mitomycin C from Streptomyces caespitosus

  • CAS Number 50-07-7

  • Empirical Formula (Hill Notation) C15H18N4O5

  • Molecular Weight 334.33

  •  Beilstein Registry Number 7231816

  •  MDL number MFCD00078109

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Description

Biochem/physiol Actions

Mode of Action: This product is an alkylating agent that specifically targets the guanine nucleoside sequence 5′-CpG-3′. It inhibits DNA synthesis by covalently reacting with DNA, forming crosslinks between complementary strands of DNA. This interaction prevents separation of complementary DNA strands, inhibiting DNA replication.

Antimicrobial Spectrum: Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria.

Other Notes

Vial contains 2 mg mitomycin C and 48 mg NaCl (increases solubility).

Same product — same quality — now Sigma-Aldrich brand

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Degradations, Eliminations, Environmental, Enzymology, Gene expression, Genetic, Infrared spectroscopy, Metabolites, Methylations, Mutagens, Oncology, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription, transformation

Peer-Reviewed Papers
15

References

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M4287 Mitomycin C from Streptomyces caespitosus, powder, BioReagent, suitable for cell culture

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