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70442 Sigma-Aldrich

1-Naphthol

≥98.0% (GC)

Synonym: α-Naphthol, 1-Hydroxynaphthalene

  • CAS Number 90-15-3

  • Linear Formula C10H7OH

  • Molecular Weight 144.17

  •  Beilstein Registry Number 1817321

  •  EC Number 201-969-4

  •  MDL number MFCD00003930

  •  PubChem Substance ID 57652248

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Properties

Related Categories Building Blocks, C9 to C20+, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds,
vapor density   4.5 (120 °C, vs air)
vapor pressure   1 mmHg ( 94 °C)
InChI Key   KJCVRFUGPWSIIH-UHFFFAOYSA-N
assay   ≥98.0% (GC)
autoignition temp.   1007 °F
expl. lim.   5 %
bp   278-280 °C(lit.)
mp   94-96 °C(lit.)
  94-96 °C
Gene Information   human ... CYP1A2(1544)

Description

Application

1-Naphthol (Naphthalen-1-ol) may be used as a standard for the NMR, FT-IR and mass spectrometric characterization of impurities present in the Duloxetine Hydrochloride active pharmaceutical ingredient (API).

General description

1-Naphthol is the hydroxyl derivative of naphthalene. It forms hydrogen bonded complexes with H2O, CH3OH, NH3 and ND3 in gas phase. Hydrogen-bond dissociation energy of these complexes has been evaluated. Its sorption by biochars (obtained from orange peels, having pyrolytic temperatures in the range of 150-700 °C and designated as OP150-OP700) has been studied. It has been identified as an impurity in the active pharmaceutical ingredient (API) of duloxetine hydrochloride.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
1
RTECS 
QL2800000
Flash Point(F) 
257 °F
Flash Point(C) 
125 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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