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75035 Sigma-Aldrich

Mettler-Toledo Calibration substance ME 18872, Caffeine

analytical standard, for the calibration of the thermosystem 900, traceable to primary standards (LGC)

Synonym: 1,3,7-Trimethylxanthine, Caffeine

  • CAS Number 58-08-2

  • Empirical Formula (Hill Notation) C8H10N4O2

  • Molecular Weight 194.19

  •  Beilstein Registry Number 17705

  •  EC Number 200-362-1

  •  MDL number MFCD00005758

  •  PubChem Substance ID 329766076

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Melting Point Standards, Physical Properties Standards
grade   analytical standard
  for the calibration of the thermosystem 900
InChI Key   RYYVLZVUVIJVGH-UHFFFAOYSA-N
form   neat
quality   traceable to primary standards (LGC)
shelf life   limited shelf life, expiry date on the certificate and label
mp   234-236.5 °C(lit.)
format   neat
Gene Information   human ... ADORA1(134), ADORA2B(136), ADORA3(140), PDE4B(5142)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369)

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

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Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
EV6475000

Documents

Certificate of Analysis

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
Are the Mettler-Toledo Calibration melting standards already dried and pulverized, ready to use out of the bottle?
The answer is yes. All melting point standards are ground to a fine powder, tested as melting point standards and ready to use.
Show more questions
Protocols & Articles

Articles

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HPLC Analysis of Beverage Additives in Diet Cola on Ascentis® Express RP-Amide

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Keywords: Chromatography, High performance liquid chromatography, Separation

HPLC Analysis of Bronchodilators Theophylline and Other Caffeine Metabolites in Serum on Discovery® RP-AmideC16 after SPE using Discovery® DSC-18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Bronchodilators Theophylline and Other Caffeine Metabolites in Serum on Discovery® RP-AmideC16 after SPE using Discovery® DSC-18
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HPLC Analysis of Caffeine and Taurine on Ascentis® Express HILIC Column using Evaporative Light Scattering Detection (ELSD)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Caffeine and Taurine on Ascentis® Express HILIC Column using Evaporative Light Scattering Detection (ELSD)
Keywords: Chromatography, High performance liquid chromatography, Normal-phase chromatography, Separation, Vitamins

HPLC Analysis of Caffeine and Taurine on Ascentis® Express HILIC Column using Evaporative Light Scattering Detection (ELSD, Fast Analysis)

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Keywords: Chromatography, High performance liquid chromatography, Normal-phase chromatography, Separation, Vitamins

HPLC Analysis of Pain Relievers on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Pain Relievers on Ascentis® Express C18
Keywords: Analgesics, Chromatography, Clinical, High performance liquid chromatography

HPLC Analysis of an Energy Drink on Ascentis® Express HILIC (UV Detection)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of an Energy Drink on Ascentis® Express HILIC (UV Detection)
Keywords: Chromatography, Detection methods, High performance liquid chromatography, Separation, Vitamins

TLC Analysis of Analgesics on HPTLC Silica Gel 60 RP-18 WF254s (analyte set 2)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Analgesics on HPTLC Silica Gel 60 RP-18 WF254s (analyte set 2)
Keywords: Chromatography, Pharmaceutical, Thin layer chromatography

TLC Analysis of Analgesics on HPTLC Silica Gel 60 RP-18 WF254s (analyte set 2)

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Keywords: Chromatography, Pharmaceutical, Thin layer chromatography

TLC Analysis of Expectorants on HPTLC Silica Gel 60 RP-18 WF254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Expectorants on HPTLC Silica Gel 60 RP-18 WF254s
Keywords: Chromatography, Pharmaceutical, Thin layer chromatography

Peer-Reviewed Papers
15

References

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