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76307 Sigma-Aldrich

Pefabloc® SC

analytical standard

Synonym: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, AEBSF

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Properties

Related Categories Additional Standards, Aliphatics, Amines, Analytical Standards, Analytical/Chromatography,
grade   analytical standard
InChI Key   WRDABNWSWOHGMS-UHFFFAOYSA-N
assay   ≥97% (HPLC)
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   ~183 °C
format   neat
storage temp.   2-8°C

Description

Application

Recommended concentrations for use are 0.1-1 mM.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25 mM.

Other Notes

Potent and irreversible inhibitor of serine proteases; in contrast to PMSF, it is water soluble and non-toxic; Unaffected by albumin

Same product — same quality — now Sigma-Aldrich brand

Legal Information

Pefabloc is a registered trademark of Pentapharm

Price and Availability

Safety & Documentation
Protocols & Articles
Peer-Reviewed Papers
15

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