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78780 Sigma-Aldrich

Phenyl isothiocyanate

for HPLC derivatization, the detection of alcohols and amines, ≥99.0%

Synonym: PITC

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Properties

Related Categories Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfur Compounds, Thiocyanates/Isothiocyanates More...
InChI Key   QKFJKGMPGYROCL-UHFFFAOYSA-N
assay   ≥99.0%
quality   for HPLC derivatization, the detection of alcohols and amines
refractive index   n20/D 1.649
  n20/D 1.6515(lit.)
bp   218 °C(lit.)
mp   −21 °C(lit.)
solubility   water: insoluble
density   1.13 g/mL at 20 °C
  1.132 g/mL at 20 °C(lit.)

Description

Application

Derivatizing reagent for primary and secondary amines. Used in sequencing peptides by Edman degradation and in amino acid analyses by HPLC.

Phenyl isothiocyanate may be employed as a derivatization reagent for high-performance liquid chromatographic (HPLC) analysis of various amphetamine derivatives in body fluids.

Packaging

25, 100, 500 mL in glass bottle

General description

Phenyl isothiocyanate is an aromatic isothiocyanate. It participates in dehydration reactions of alcohols. It is widely used for synthesis of various biologically important heterocyclic compounds.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2927 8(6.1) / PGII
WGK Germany 
3
RTECS 
NX9275000
Flash Point(F) 
190.4 °F
Flash Point(C) 
88 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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