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85588 Sigma-Aldrich

Spermine dihydrate

BioUltra, ≥99.5% (GC)

Synonym: Gerontine, Musculamine, N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Neuridine

  • CAS Number 403982-64-9

  • Linear Formula NH2(CH2)3NH(CH2)4NH(CH2)3NH2 · 2H2O

  • Molecular Weight 238.37

  •  Beilstein Registry Number 7526933

  •  EC Number 200-754-2

  •  MDL number MFCD01459904

  •  PubChem Substance ID 329769391

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Properties

InChI Key   MTNRSMVAYLLBAV-UHFFFAOYSA-N
product line   BioUltra
assay   ≥99.5% (GC)
impurities   insoluble matter, passes filter test
pH   12.0-13.5 (25 °C, 1 M in H2O)
mp   63-64 °C
solubility   H2O: soluble1 M at 20 °C, clear, colorless
anion traces   chloride (Cl-): ≤50 mg/kg
  sulfate (SO42-): ≤50 mg/kg
cation traces   Al: ≤5 mg/kg
  As: ≤0.1 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
λ   1 M in H2O
UV absorption   λ: 260 nm Amax: 0.20
  λ: 280 nm Amax: 0.20
storage temp.   2-8°C
Gene Information   human ... GRIN2B(2904)
rat ... Grin2a(24409)

Description

Other Notes

Polyamines: Review; Inhibitor of ATPase; DNA polymerase; ribonuclease

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

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Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3259PSN1 8 / PGII
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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