EMAIL THIS PAGE TO A FRIEND
85588 Sigma-Aldrich

Spermine dihydrate

BioUltra, ≥99.5% (GC)

Synonym: Gerontine, Musculamine, N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Neuridine

  • CAS Number 403982-64-9

  • Linear Formula NH2(CH2)3NH(CH2)4NH(CH2)3NH2 · 2H2O

  • Molecular Weight 238.37

  •  Beilstein Registry Number 7526933

  •  EC Number 200-754-2

  •  MDL number MFCD01459904

  •  PubChem Substance ID 329769391

Purchase

Properties

InChI Key   MTNRSMVAYLLBAV-UHFFFAOYSA-N
product line   BioUltra
assay   ≥99.5% (GC)
impurities   insoluble matter, passes filter test
pH   12.0-13.5 (25 °C, 1 M in H2O)
mp   63-64 °C
solubility   H2O: soluble1 M at 20 °C, clear, colorless
anion traces   chloride (Cl-): ≤50 mg/kg
  sulfate (SO42-): ≤50 mg/kg
cation traces   Al: ≤5 mg/kg
  As: ≤0.1 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
λ   1 M in H2O
UV absorption   λ: 260 nm Amax: 0.20
  λ: 280 nm Amax: 0.20
storage temp.   2-8°C
Gene Information   human ... GRIN2B(2904)
rat ... Grin2a(24409)

Description

Other Notes

Polyamines: Review; Inhibitor of ATPase; DNA polymerase; ribonuclease

Same product — same quality — now Sigma-Aldrich brand

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3259PSN1 8 / PGII
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

related product

Product #

Description

Add to Cart

08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?