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85886 Sigma-Aldrich

Streptomycin solution

~1 mg/mL in 1 mM EDTA, analytical standard

  • CAS Number 3810-74-0

  • Empirical Formula (Hill Notation) C21H39N7O12 · 1.5H2SO4

  • Molecular Weight 728.69

  •  MDL number MFCD00037023

  •  PubChem Substance ID 329769423

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Properties

Related Categories Additional Standards, Aminoglycosides, Analytical Standards, Analytical/Chromatography, Antibacterial,
grade   analytical standard
InChI Key   QTENRWWVYAAPBI-YZTFXSNBSA-N
form   liquid
concentration   ~1 mg/mL in 1 mM EDTA
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
color   colorless
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
format   single component solution
storage temp.   2-8°C

Description

Biochem/physiol Actions

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial Spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

Packaging

10ml

Preparation Note

This product contains 1 mg/mL Streptomycin in 1 mM EDTA and should be stored at 2-8°C.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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