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85886 Sigma-Aldrich

Streptomycin solution

~1 mg/mL in 1 mM EDTA, analytical standard

  • CAS Number 3810-74-0

  • Empirical Formula (Hill Notation) C21H39N7O12 · 1.5H2SO4

  • Molecular Weight 728.69

  •  MDL number MFCD00037023

  •  PubChem Substance ID 329769423

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Properties

Related Categories Additional Standards, Aminoglycosides, Analytical Standards, Analytical/Chromatography, Antibacterial,
grade   analytical standard
InChI Key   QTENRWWVYAAPBI-YZTFXSNBSA-N
concentration   ~1 mg/mL in 1 mM EDTA
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
format   single component solution
storage temp.   2-8°C

Description

Biochem/physiol Actions

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial Spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

Preparation Note

This product contains 1 mg/mL Streptomycin in 1 mM EDTA and should be stored at 2-8°C.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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