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86900 Sigma-Aldrich

Tetrabutylammonium fluoride solution

purum, ~1 M in THF

Synonym: TBAF solution

  • CAS Number 429-41-4

  • Linear Formula [CH3(CH2)3]4NF

  • Molecular Weight 261.46

  •  Beilstein Registry Number 3762762

  •  MDL number MFCD00011747

  •  PubChem Substance ID 329769346

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Properties

Related Categories Chemical Synthesis, Deprotecting Reagents, Fluoride Sources, Protection and Derivatization, Synthetic Reagents More...
InChI Key   FPGGTKZVZWFYPV-UHFFFAOYSA-M
grade   purum
concentration   ~1 M in THF
impurities   4-5% water
storage temp.   2-8°C

Description

Application

Reactant for preparation of:
• Triple monoamine reuptake inhibitors as a new generation of antidepressants
• Alcohols via hydrolysis of alkyl silyl ethers neutral pH in mixed organic-aqueous buffered solutions
• Oligoribonucleotides with phosphonate-modified linkages
• Aryl alkyl alcohols via Nozaki-Hiyama allylation catalyzed by chiral bipyridyldiol ligands and chromium trichloride
• Conjugated dienoic acid esters using Suzuki coupling reactions
• Macrocyclic o-aminobenzamide Hsp90 inhibitorwith antitumor activity
• Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors
• Anti-diabetic polyacetylenic glucosides

Price and Availability

Safety & Documentation

Safety Information

Signal word 
Danger
Hazard statements 
Supplemental Hazard Statements 
May form explosive peroxides.
RIDADR 
UN 2924 8(3) / PGII
WGK Germany 
3
Flash Point(F) 
1.4 °F
Flash Point(C) 
-17 °C

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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216143 Tetrabutylammonium fluoride solution, 1.0 M in THF

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