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  • 89730 - p-Toluenesulfonyl chloride


89730 Sigma-Aldrich

p-Toluenesulfonyl chloride

ReagentPlus®, ≥99.0%

Synonym: Tosyl chloride

  • CAS Number 98-59-9

  • Linear Formula CH3C6H4SO2Cl

  • Molecular Weight 190.65

  •  Beilstein Registry Number 607898

  •  EC Number 202-684-8

  •  MDL number MFCD00007450

  •  PubChem Substance ID 24889256



Related Categories Analytical Reagents, Analytical/Chromatography, Chemical Synthesis, Derivatization Reagents, Derivatization Reagents HPLC,
grade   ReagentPlus®
vapor pressure   1 mmHg ( 88 °C)
assay   ≥99.0%
bp   134 °C/10 mmHg(lit.)
mp   65-69 °C(lit.)
  66-69 °C
solubility   methylene chloride: soluble0.2 g/mL, clear


Other Notes

Same product — same quality — now Sigma-Aldrich brand

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

Suggested Laboratory Gloves

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Safety & Documentation

Safety Information

GHS05  GHS05
Signal word 
Hazard statements 
Precautionary statements 
UN 3261 8 / PGIII
WGK Germany 
Flash Point(F) 
262.4 °F
Flash Point(C) 
128 °C

Protocols & Articles

Peer-Reviewed Papers


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Immobilization of collagen onto polymer surfaces having hydroxyl groups. Tabata Y, Lonikar SV, Horii F, et al. Biomaterials 7(3), 234-8, (1986)


Single hollow fiber SLM extraction of polyamines followed by tosyl chloride derivatization and HPLC determination. Dziarkowska K, Jönsson JA, and Wieczorek PP Anal. Chim. Acta 606(2), 184-93, (2008)


Para-toluenesulfonyl chloride. Am. Ind. Hyg. Assoc. J. 43(10), B53-4, (1982)


[Surface charge of mouse neuroblastoma cells and changes during growth and morphologic differentiation of the cell population]. Dolgaia EV, Mironov SL, and Pogorelaia NKh Neirofiziologiia 17(2), 168-74, (1985)


Contribution of different scintigraphic techniques to the management of medullary thyroid carcinoma. Sandrock D, Blossey HC, Steinroeder M, et al. Henry Ford Hosp. Med. J. 37(3-4), 173-4, (1989)


Copper(II)-complex directed regioselective mono-p-toluenesulfonylation of cyclomaltoheptaose at a primary hydroxyl group position: an NMR and molecular dynamics-aided design. Law H, Benito JM, Fernández JM, et al. J. Phys. Chem. B 115(23), 7524-32, (2011)


Determination of glyphosate and its metabolite aminomethylphosphonic acid in fruit juices using supported-liquid membrane preconcentration method with high-performance liquid chromatography and UV detection after derivatization with p-toluenesulphonyl chloride. Khrolenko MV and Wieczorek PP J. Chromatogr. A 1093(1-2), 111-7, (2005)


Isothiocyanates from tosyl chloride mediated decomposition of in situ generated dithiocarbamic acid salts. Wong R and Dolman SJ J. Org. Chem. 72(10), 3969-71, (2007)


Kinetics and mechanism of imidazole-catalyzed acylation of cellulose in LiCl/N,N-dimethylacetamide. Nawaz H, Pires PA, and El Seoud OA Carbohydr. Polym. 92(2), 997-1005, (2013)


Application of the dissociative electron transfer theory and its extension to the case of in-cage interactions in the electrochemical reduction of arene sulfonyl chlorides. Houmam A and Hamed EM Phys. Chem. Chem. Phys. 14(1), 113-24, (2012)


High-performance liquid chromatographic determination of glyphosate and (aminomethyl)phosphonic acid in human serum after conversion into p-toluenesulphonyl derivatives. Tomita M, Okuyama T, Watanabe S, et al. J. Chromatogr. A 566(1), 239-43, (1991)


Surface modifications of alginate/poly(L-lysine) microcapsular membranes with poly(ethylene glycol) and poly(vinyl alcohol). Kung IM, Wang FF, Chang YC, et al. Biomaterials 16(8), 649-55, (1995)


Synthesis and properties of optically active nanostructured polymers bearing amino acid moieties by direct polycondensation of 4,4'-thiobis(2-tert-butyl-5-methylphenol) with chiral diacids. Mallakpour S and Soltanian S Amino Acids 42(6), 2187-94, (2012)


[Degradation reactions of oral antidiabetics. 2. Reaction of arylsulfonylureas with 4-toluenesulfonyl chloride]. Egg H, Leibetseder H, Patzak A, et al. Arch. Pharm. (Weinheim) 320(3), 253-7, (1987)


Studies of the synthesis of biomarkers. VII. Synthesis of 5 alpha-(17R,20R)-14,15-secocholestane. Li TS, Li YL, and Liang XT Steroids 55(6), 263-5, (1990)


Occupational contact dermatitis from tosyl chloride in a chemist. Watsky KL, Reynolds K, Berube D, et al. Contact Dermatitis 29(4), 211-2, (1993)


Direct regioselective 2-O-(p-toluenesulfonylation) of sucrose. Teranishi K Carbohydr. Res. 337(7), 613-9, (2002)


Treatment of alcohols with tosyl chloride does not always lead to the formation of tosylates. Ding R, He Y, Wang X, et al. Molecules 16(7), 5665-73, (2011)


Development and validation of an HPLC-DAD method for quantification of bornesitol in extracts from Hancornia speciosa leaves after derivatization with p-toluenesulfonyl chloride. Pereira AB, Veríssimo TM, Oliveira MA, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 887-888, 133-7, (2012)


DNase activity of micrococcal endonuclease insolubilized on corn cob. Sánchez-Montero JM, Sinisterra JV, and Ballesteros A Appl. Biochem. Biotechnol. 22(2), 205-14, (1989)


The analysis of platelet reaction, utilizing various inhibitors of platelet aggregation. Kambayashi J, Nomura T, Fujimoto T, et al. Nippon. Ketsueki Gakkai Zasshi 43(6), 1145-54, (1980)


Synthesis of 1,2-unsaturated pyranosylphosphonate nucleosides from 3,4,6-tri-O-acetyl-D-glycal. Ismail AH Pharmazie 56(7), 534-5, (2001)


(4S,5S)-4-methyl-5-phenyl-1,3-oxazolidin-2-one. Robinson PD, Hua DH, Good LA, et al. Acta Crystallogr. C 49 ( Pt 6), 1238-40, (1993)


Chemical modification of milk xanthine oxidase with different modifiers. Aboul-Enein HY, Refaie MO, El-Gazzar H, et al. Prep Biochem Biotechnol. 33(3), 173-87, (2003)


Tosyl chloride. Schmidt RJ Contact Dermatitis 32(2), 124-5, (1995)


Merck 14,9534

Beil. 11,IV,375

Fieser 1,1179 / Fieser 3,292 / Fieser 4,510 / Fieser 5,676 / Fieser 6,598 / Fieser 8,489 / Fieser 9,472 / Fieser 11,536 / Fieser 13,313

Aldrich MSDS 1, 1715:C / Corp MSDS 1 (2), 3367:C / FT-IR 1 (2), 520:B / FT-IR 2 (2), 3276:C / FT-NMR 1 (2), 1620:B / IR-Spectra (2), 1018:B / IR-Spectra (3), 1169:D / NMR-Reference 2 (2), 839:C / RegBook 1 (2), 2229:I / Sax 6, 2591 / Sigma FT-IR 1 (2), 932:D / Structure Index 1, 350:B:1

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