90871 Sigma-Aldrich

Isopropyl acetate

analytical standard

Synonym: Acetic acid isopropyl ester

  • CAS Number 108-21-4

  • Linear Formula CH3COOCH(CH3)2

  • Molecular Weight 102.13

  •  Beilstein Registry Number 1740761

  •  EC Number 203-561-1

  •  MDL number MFCD00008877

  •  PubChem Substance ID 329769958



Related Categories A-L, Additional Standards, All Alphabetically Sorted, Alpha Sort, Analytical Standards,
grade   analytical standard
vapor density   3.5 (vs air)
vapor pressure   47 mmHg ( 20 °C)
assay   ≥99.8% (GC)
form   neat
autoignition temp.   894 °F
shelf life   limited shelf life, expiry date on the label
expl. lim.   1.8 %, 37 °F
  8 %
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
refractive index   n20/D 1.377(lit.)
  n20/D 1.377
bp   85-91 °C(lit.)
mp   −73 °C(lit.)
density   0.872 g/mL at 25 °C(lit.)
format   neat


Other Notes

Same product — same quality — now Sigma-Aldrich brand


Isopropyl acetate may be employed as model oxygenate compound to evaluate the catalytic efficiency of La0.8Sr0.2MnO3+x perovskite catalyst for the oxidation of various oxy-derivative compounds. It may be used as extracting reagent for the N,N-dimethyl-2-[5-(cyanomethyl)-1H-indol-3-yl]ethylamine.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Isopropyl acetate is an isopropyl ester of acetic acid. It participates in the mesoporous Al-MCM-41 (Si/Al = 55 and 104) and Al, Zn-MCM-41 (Si/(Al+Zn) = 52) molecular sieves catalyzed alkylation of m-cresol. It is widely used for the incorporation of aroma to various cosmetics and food products. Vapor-liquid equilibria for its binary mixture with CO2 at higher pressures has been evaluated.

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Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Supplemental Hazard Statements 
Repeated exposure may cause skin dryness or cracking.
UN1220 - class 3 - PG 2 - Isopropyl acetate
WGK Germany 
Flash Point(F) 
39.2 °F
Flash Point(C) 
4 °C
Protocols & Articles


The Utility of Headspace Grade Solvents for the Analysis of Organic Volatile Impurities

Organic volatile impurities or “OVIs” sometimes remain behind in pharmaceutical preparations as a result of synthetic and manufacturing procedures. For reasons of health and safety, testing is done t...
Katherine Stenerson, Shyam Verma
Reporter US Volume 28.1
Keywords: Chromatography, Gas chromatography, Organic synthesis, Pharmaceutical, Solvents

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