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A36883 Sigma-Aldrich

Aurintricarboxylic acid ammonium salt

ACS reagent

Synonym: ATA, Aluminon, Ammonium aurintricarboxylate

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Properties

Related Categories Biochemicals and Reagents, Building Blocks, Carbonyl Compounds, Carboxylic Acid Salts, Chemical Synthesis,
grade   ACS reagent
InChI Key   AIPNSHNRCQOTRI-UHFFFAOYSA-N
impurities   ≤0.1% insolubles
ign. residue   ≤0.2%
mp   220-225 °C (dec.)(lit.)
absorption   λmax 450 nm
  λmax 522 nm (2nd)

Description

Application

Reagent for aluminum

Other Notes

May contain a substantial amount of polymeric material.

Packaging

25, 100 g in poly bottle

Biochem/physiol Actions

Aurintricarboxylic acid readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis.

Price and Availability

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
GU4800000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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