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A92902 Sigma-Aldrich

L-Ascorbic acid

99%

Synonym: L-Threoascorbic acid, Antiscorbutic factor, Vitamin C

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Description

Packaging

2 kg in poly drum

25, 100, 500 g in poly bottle

Biochem/physiol Actions

Ascorbic Acid, also known as Vitamin C, is a six-carbon lactone produced by plants and some animal species but not by humans and other primates. Ascorbic acid functions as an enzymatic cofactor for multiple enzymes, serving as an electron donor for monooxygenases and dioxygenases. Ascorbic acid also functions as a powerful antioxidant, particularly in regards to reactive oxygen species.

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BioUltra, ≥99.5% (RT)

<SC>L</SC>-Ascorbic acid

puriss. p.a., ≥99.0% (RT)

<SC>L</SC>-Ascorbic acid

analytical standard

Safety & Documentation

Safety Information

WGK Germany 
1
RTECS 
CI7650000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Determination of Water Content in Ascorbic acid (Vitamin C) Using Karl Fischer Titration

Ascorbic acid (vitamin C) reacts with the iodine present in the KF reagent and causes an artificially high water content. We tried different working procedures and reagents system also the indirect t...
Keywords: Pharmaceutical, Titrations, Vitamins

Determination of Water Content in Ascorbic acid Using Karl Fischer Titration

Ascorbic acid causes a fast side reaction with iodine during KF titration. 1 mmol of ascorbic acid simulates 1 mmol of water. We investigated a sample under different conditions like direct volumetri...
Keywords: Pharmaceutical, Titrations

Peer-Reviewed Papers

References

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Ascorbic acid: a review of its chemistry and reactivity in relation to a wine environment. Bradshaw MP, Barril C, Clark AC, et al. Crit. Rev. Food Sci. Nutr 51(6), 479-98, (2011)

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Nitric oxide activates TRP channels by cysteine S-nitrosylation. Takashi Yoshida et al Nat. Chem. Biol. 2, 596-607, (2006)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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The sodium-dependent ascorbic acid transporter family SLC23. Bürzle M, Suzuki Y, Ackermann D, et al. Mol. Aspects Med. 34(2-3), 436-54, (2013)

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Patternable nanowire sensors for electrochemical recording of dopamine. Tyagi P Anal. Chem. 81(24), 9979-84, (2009)

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The role of L-ascorbic acid recycling in responding to environmental stress and in promoting plant growth. Gallie DR J. Exp. Bot. 64(2), 433-43, (2013)

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Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. Balaram Ghosh et al J. Med. Chem. 53, 1023-37, (2010)

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Mesenchymal stem cell proliferation and differentiation on an injectable calcium phosphate-chitosan composite scaffold. Moreau JL Biomaterials 30(14), 2675-82, (2009)

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Ascorbic acid: chemistry, biology and the treatment of cancer. Du J, Cullen JJ, and Buettner GR Biochim. Biophys. Acta 1826(2), 443-57, (2012)

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Determination of the fate and contribution of ex vivo expanded human bone marrow stem and progenitor cells for bone formation by 2.3ColGFP. Dezhong Yin et al Mol. Ther. 17, 1967-78, (2009)

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Bioactive metabolites from the Caribbean sponge Aka coralliphagum. Achim Grube et al J. Nat. Prod. 70, 504-9, (2007)

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Clinically relevant cell sources for TMJ disc engineering. D.E. Johns et al J. Dent. Res. 87, 548-52, (2010)

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An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds. Yunbao Liu et al J. Nat. Prod. 73, 1193-5, (2010)

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Serotonin at the level of the amygdala and orbitofrontal cortex modulates distinct aspects of positive emotion in primates. Int. J. Neuropsychopharmacol., 1-15, (2011)

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Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita. Min Hye Yang et al Bioorg. Med. Chem. 17, 2689-94, (2009)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Differentiating human multipotent mesenchymal stromal cells regulate microRNAs: prediction of microRNA regulation by PDGF during osteogenesis. Goff, LA Exp. Hematol. 36(10), 1354-1369, (2008)

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L-Ascorbic acid biosynthesis. Smirnoff, N. Vitam. Horm. 61, 241-266, (2001)

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Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process. Kim MS, Kim JS, Park HJ, et al. Int. J. Nanomedicine 6, 2997-3009, (2011)

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Structural characterization and DPPH radical scavenging activity of an arabinoglucogalactan from Panax notoginseng root. Yalin Wu et al J. Nat. Prod. 71, 241-5, (2008)

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Antioxidant vitamin intake and mortality: the Leisure World Cohort Study. Paganini-Hill A, Kawas CH, and Corrada MM Am. J. Epidemiol. 181(2), 120-6, (2015)

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Evaluation of bactericidal effect of three antiseptics on bacteria isolated from wounds. Kumara DU, Fernando SS, Kottahachchi J, et al. J. Wound Care 24(1), 5-10, (2015)

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Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. Wade KH, Forouhi NG, Cook DG, et al. Am. J. Clin. Nutr. 101(1), 202-9, (2015)

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Interventions for fatigue in peripheral neuropathy. White CM, van Doorn PA, Garssen MP, et al. Cochrane Database Syst. Rev. 12, CD008146, (2014)

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Regulation of auxin, abscisic acid and salicylic acid levels by ascorbate application under heat stress in sensitive and tolerant maize leaves. Dinler BS, Demir E, and Kompe YO Acta Biol. Hung. 65(4), 469-80, (2014)

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Identification and initial characterisation of a Plasmodium falciparum Cox17 copper metallochaperone. Choveaux DL, Krause RG, Przyborski JM, et al. Exp. Parasitol. 148, 30-9, (2015)

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Supplementation with multivitamins and vitamin A and incidence of malaria among HIV-infected Tanzanian women. Olofin IO, Spiegelman D, Aboud S, et al. J. Acquir. Immune Defic. Syndr. 67 Suppl 4, S173-8, (2014)

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Effects of combined treatment of α-tocopherol, L-ascorbic acid, selenium and zinc on bleomycin, etoposide and cisplatin-induced alterations in testosterone synthesis pathway in rats. Kilarkaje N Cancer Chemother. Pharmacol. 74(6), 1175-89, (2014)

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Orange juice intake reduces patient discomfort and is effective for bowel cleansing with polyethylene glycol during bowel preparation. Choi HS, Shim CS, Kim GW, et al. Dis. Colon Rectum 57(10), 1220-7, (2014)

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Treatment response to antioxidants and zinc based on CFH and ARMS2 genetic risk allele number in the Age-Related Eye Disease Study. Awh CC, Hawken S, and Zanke BW Ophthalmology 122(1), 162-9, (2015)

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Technical advance: ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells. Huijskens MJ, Walczak M, Koller N, et al. J. Leukoc. Biol. 96(6), 1165-75, (2014)

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Antioxidants for pain in chronic pancreatitis. Ahmed Ali U, Jens S, Busch OR, et al. Cochrane Database Syst. Rev. 8, CD008945, (2014)

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Associations between three specific a-cellular measures of the oxidative potential of particulate matter and markers of acute airway and nasal inflammation in healthy volunteers. Janssen NA, Strak M, Yang A, et al. Occup. Environ. Med. 72(1), 49-56, (2015)

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Antioxidant supplementation for lung disease in cystic fibrosis. Ciofu O and Lykkesfeldt J Cochrane Database Syst. Rev. 8, CD007020, (2014)

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Chondrocytes expressing intracellular collagen type II enter the cell cycle and co-express collagen type I in monolayer culture. Tekari A, Luginbuehl R, Hofstetter W, et al. J. Orthop. Res. 32(11), 1503-11, (2014)

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Consumption of both low and high (-)-epicatechin apple puree attenuates platelet reactivity and increases plasma concentrations of nitric oxide metabolites: a randomized controlled trial. Gasper A, Hollands W, Casgrain A, et al. Arch. Biochem. Biophys. 559, 29-37, (2014)

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Adding ascorbic acid to arsenic trioxide produces limited benefit in patients with acute myeloid leukemia excluding acute promyelocytic leukemia. Aldoss I, Mark L, Vrona J, et al. Ann. Hematol. 93(11), 1839-43, (2014)

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Effects of the acute exposition to glyphosate-based herbicide on oxidative stress parameters and antioxidant responses in a hybrid Amazon fish surubim (Pseudoplatystoma sp). Sinhorin VD, Sinhorin AP, Teixeira JM, et al. Ecotoxicol. Environ. Saf. 106, 181-7, (2014)

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Short-term effect of ascorbate on bacterial content, plasminogen activator inhibitor-1, and myeloperoxidase in septic mice. Swarbreck SB, Secor D, Ellis CG, et al. J. Surg. Res. 191(2), 432-40, (2014)

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Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition. Leenders M, Leufkens AM, Siersema PD, et al. Int. J. Cancer 135(12), 2930-9, (2014)

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Ascorbic acid induces either differentiation or apoptosis in MG-63 osteosarcoma lineage. Valenti MT, Zanatta M, Donatelli L, et al. Anticancer Res. 34(4), 1617-27, (2014)

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Behavioral pattern of physicochemical constituents of the postharvest mango (Mangifera indica L.) influenced by storage stimuli. Islam MK Pak. J. Biol. Sci. 16(24), 1985-90, (2013)

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Efficacy of supplementary vitamins C and E on anxiety, depression and stress in type 2 diabetic patients: a randomized, single-blind, placebo-controlled trial. Mazloom Z, Ekramzadeh M, and Hejazi N Pak. J. Biol. Sci. 16(22), 1597-600, (2013)

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[Glucose, ascorbic acid and hydrogen peroxide as ingredients of endoscopic hemostasis in bleeding ulcer]. Timen LIa, Machneva TV, Trubitsina IE, et al. Eksp. Klin. Gastroenterol. (5), 89-92, (2013)

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Associations between supplemental or dietary intake of vitamin C and severity of lower urinary tract symptoms. Curto TM, Giovannucci EL, McKinlay JB, et al. BJU Int. 115(1), 134-42, (2015)

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The effect of zinc and vitamin C supplementation on hemoglobin and hematocrit levels and immune response in patients with Plasmodium vivax malaria. Zen Rahfiludin M and Ginandjar P Southeast Asian J. Trop. Med. Public Health 44(5), 733-9, (2013)

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Secondary oxalosis due to excess vitamin C intake: a cause of graft loss in a renal transplant recipient. Yaich S, Chaabouni Y, Charfeddine K, et al. Saudi J. Kidney Dis. Transpl. 25(1), 113-6, (2014)

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Eating for good vision. Add these nutrients to your diet to preserve and protect your eyesight. Harv. Womens. Health Watch 21(2), 6, (2013)

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Vitamin C and percutaneous coronary intervention: some answers, more questions. Gebhard C and Tardif JC Can. J. Cardiol. 30(1), 3-5, (2014)

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FPIN's clinical inquiries. Treatments for symptoms of the common cold. Livingston C, Cozzens J, and Hamilton A Am. Fam. Physician 88(12), Online, (2013)

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[Vitamin C]. Fain O Rev. Prat. 63(8), 1091-6, (2013)

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Epigenetics, vitamin supplements and cellular reprogramming. Pera MF Nat. Genet. 45(12), 1412-3, (2013)

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[The impact of ascorbic acid on the concentrations of antioxidative vitamins in the plasma of patients with non-small cell lung cancer undergoing first-line chemotherapy]. Tokarski S, Rutkowski M, Godala M, et al. Pol. Merkur. Lekarski 35(207), 136-40, (2013)

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[Not too eager prescribing vitamin C for the common cold!]. Senn N Rev. Med. Suisse 9(401), 1854-5, (2013)

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Does ascorbic acid protect against contrast-induced acute kidney injury in patients undergoing coronary angiography: a systematic review with meta-analysis of randomized, controlled trials. Sadat U, Usman A, Gillard JH, et al. J. Am. Coll. Cardiol. 62(23), 2167-75, (2013)

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[Cardiomyocyte differentiation of individual clones murine induced pluripotent stem cells]. Malysheva SV, Budash HV, Bil'ko NM, et al. Fiziol. Zh. 59(3), 10-7, (2013)

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Minocycline, but not ascorbic acid, increases motor activity and extends the life span of Drosophila melanogaster. Mora M, Medina-Leendertz SJ, Bonilla E, et al. Invest. Clin. 54(2), 161-70, (2013)

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Rapid recovery time of hemoglobin level in female regular blood donors with ferrous fumarate and high dose of ascorbic acid supplement. Chiamchanya N J. Med. Assoc. Thai. 96(2), 165-71, (2013)

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Lauroyl/palmitoyl glycol chitosan gels enhance skin delivery of magnesium ascorbyl phosphate. Wang PC, Huang YL, Hou SS, et al. J. Cosmet. Sci. 64(4), 273-86, (2013)

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[Treatment of ulcerated lower leg eczema with high-dose vitamin C therapy]. Hakimi R Versicherungsmedizin 65(2), 100, (2013)

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Fabrication and characterization of gold nanoflowers formed via chitosan-tripolyphosphate template films for biomedical applications. Nhung TT, Kang IJ, and Lee SW J. Nanosci. Nanotechnol. 13(8), 5346-50, (2013)

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Role of vitamins D, E and C in immunity and inflammation. Shaik-Dasthagirisaheb YB, Varvara G, Murmura G, et al. J. Biol. Regul. Homeost. Agents 27(2), 291-5, (2013)

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Dietary intake of antioxidant vitamins in healthy adults in relation to current recommended intake. Jabłonowska-Lietz B, Jarosz A, and Nowicka G Rocz. Panstw. Zakl. Hig. 64(1), 43-8, (2013)

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Visual outcome after antioxidant supplementation. Beatty S, Nolan JM, Muldrew KA, et al. Ophthalmology 120(3), 645, (2013)

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Neurotoxic effects of administration of artemisinin combination therapy (artemether and quinine) and ascorbic acid on the cytoarchitecture of the cerebellum and trapezoid nuclei in adult rats. Akinlolu AA, Kassim LS, and Shokunbi MT Afr. J. Med. Med. Sci. 41 Suppl, 149-55, (2012)

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[Micronutrients in oncology. Current data about vitamin D, selenium, L-carnitine and vitamin C]. Gröber U, Mücke R, Holzhauer P, et al. Med. Monatsschr. Pharm. 36(4), 133-43; quiz 145-6, (2013)

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[Effect of electrical stimulation on the differentiation of induced pluripotent stem cells into cardiomyocytes induced by vitamin C in vitro]. Dai Y, Qin J, Zhang X, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 29(4), 364-7, (2013)

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Ascorbic acid and sodium-dependent vitamin C transporters in the peripheral nervous system: from basic science to clinical trials. Gess B, Röhr D, and Young P Antioxid. Redox Signal. 19(17), 2105-14, (2013)

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Regulation of ascorbic acid synthesis in plants. Wang J, Zhang Z, and Huang R Plant Signal Behav. 8(6), e24536, (2013)

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Is intravenous ascorbic acid an effective and safe option for increasing hemoglobin levels in patients with a hyporesponse to epoetin alfa? Kear TM Nephrol. Nurs. J. 39(2), 137-40, (2012)

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Helicobacter pylori Infection of Gastrointestinal Epithelial Cells in vitro Induces Mesenchymal Stem Cell Migration through an NF-κB-Dependent Pathway. Jonathan Ferrand et al PLoS ONE 6, DOI: 10.1093/ecam/nen085, (2011)

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[Recent advance in the study of ascorbic acid in photosynthe-sizing organisms]. Ishikawa T Seikagaku. 83(9), 838-41, (2011)

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L-Proline anchored multicomponent synthesis of novel pyrido[2,3-a]carbazoles; investigation of in vitro antimicrobial, antioxidant, cytotoxicity and structure activity relationship studies. T Indumathi et al Eur. J. Med. Chem. 46, 5580-90, (2011)

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Synthesis and evaluation of antioxidant and antibacterial activities of new substituted bis(1,3,4-oxadiazoles), 3,5-bis(substituted) pyrazoles and isoxazoles. Ebraheem Abdu Musad et al Bioorg. Med. Chem. Lett. 21, 3536-40, (2011)

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Synthesis of cinnamoyl ketoamides as hybrid structures of antioxidants and calpain inhibitors. Yeong Jae Yoo et al Bioorg. Med. Chem. Lett. 21, 2850-4, (2011)

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Synthesis and bio-activity evaluation of tetraphenyl(phenylamino) methylene bisphosphonates as antioxidant agents and as potent inhibitors of osteoclasts in vitro. A Balakrishna et al Eur. J. Med. Chem. 46, 1798-802, (2011)

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Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs. Elisabetta Martini et al J. Med. Chem. 54, 2512-6, (2011)

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Synthesis and biological activity of 2-(bis((1,3,4-oxadiazolyl/1,3,4-thiadiazolyl)methylthio)methylene)malononitriles. V Padmavathi et al Eur. J. Med. Chem. 46, 1367-73, (2011)

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Micronutrients at the interface between inflammation and infection--ascorbic acid and calciferol: part 1, general overview with a focus on ascorbic acid. Ströhle A, Wolters M, Hahn A. Inflamm. Allergy Drug Targets 10, 54-63, (2011)

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Antioxidant, anti-inflammatory and anti-hyperglycaemic activities of heterocyclic homoprostanoid derivatives. S A Manohara Reddy et al Bioorg. Med. Chem. 19, 384-92, (2011)

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The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts. Id Boufker H, Lagneaux L, Najar M, et al. BMC Cancer 10, 298, (2010)

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Differentiation of neural precursors and dopaminergic neurons from human embryonic stem cells. Zhang XQ and Zhang SC Methods Mol. Biol. 584, 355-66, (2010)

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Stromagenesis During Tumorigenesis: Characterization Of Tumor-associated Fibroblasts And Stroma-derived 3D Matrices. Castelló-Cros, R., and Cukierman, E. Methods Mol. Biol. 522, 275-305, (2009)

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Fibrin and poly(lactic-co-glycolic acid) hybrid scaffold promotes early chondrogenesis of articular chondrocytes: an in vitro study. Sha'ban M J. Orthop. Surg. Res. 3, 17, (2008)

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[Role of alpha-tocopherol and L-ascorbic acid in mammalian reproduction]. Tao Y, Zhang MJ, and Xie HR Sheng Li Ke Xue Jin Zhan 36(1), 74-6, (2005)

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Bioavailability and biological activity of L-ascorbic acid 2-O-alpha-glucoside. Yamamoto I and Muto N J. Nutr. Sci. Vitaminol. Spec No, 161-4, (1992)

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[The role of L-ascorbic acid in free radical reactions]. Kleszczewska E Postepy. Hig. Med. Dosw. 56(5), 655-69, (2002)

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[Biological role of reactions of L-ascorbic acid with metals]. Kleszczewska E Postepy. Hig. Med. Dosw. 55(1), 81-94, (2001)

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[Contemporary opinions on the role and properties of L-ascorbic acid]. Kleszczewska E Pol. Merkur. Lekarski 8(45), 155-8, (2000)

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Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus. Hyoung Ja Kim et al J. Nat. Prod. 69, 600-3, (2006)

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(-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant. Hui-Min Wang et al Bioorg. Med. Chem. 18, 5241-7, (2010)

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Metabolic engineering of plant L-ascorbic acid biosynthesis: recent trends and applications. Zhang L, Wang Z, Xia Y, et al. Crit. Rev. Biotechnol. 27(3), 173-82, (2007)

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Chlorinated iridoid glucosides from Veronica longifolia and their antioxidant activity. Søren R Jensen et al J. Nat. Prod. 73, 1593-6, (2010)

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Estrogen receptor α36 mediates a bone-sparing effect of 17β-estrodiol in postmenopausal women. Xie H, Sun M, Liao XB, et al. J. Bone Miner Res. 26(1), 156-68, (2011)

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Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? Abdullah Ozer et al Nat. Chem. Biol. 3, 144-53, (2007)

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Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Blaschke K, Ebata KT, Karimi MM, et al. Nature 500(7461), 222-6, (2013)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Synthesis of chromone carboxamide derivatives with antioxidative and calpain inhibitory properties. Sang Hoon Kim et al Eur. J. Med. Chem. 46, 1721-8, (2011)

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Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins. Lean-Teik Ng et al Bioorg. Med. Chem. 17, 4360-6, (2009)

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Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant. Valpuesta V and Botella MA Trends Plant Sci. 9(12), 573-7, (2004)

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Improving the nutritional value of crops through enhancement of L-ascorbic acid (vitamin C) content: rationale and biotechnological opportunities. Hancock RD and Viola R J. Agric. Food Chem. 53(13), 5248-57, (2005)

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Antiprotozoal activity of chloroquinoline based chalcones. Faisal Hayat et al Eur. J. Med. Chem. 46, 1897-905, (2011)

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Lipocarbazoles, secondary metabolites from Tsukamurella pseudospumae Acta 1857 with antioxidative activity. Kathrin Schneider et al J. Nat. Prod. 72, 1768-72, (2009)

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Glucose-containing flavones--their synthesis and antioxidant and neuroprotective activities. Seung Hwan Kim et al Bioorg. Med. Chem. Lett. 19, 6009-13, (2009)

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Functions, applications and production of 2-O-D-glucopyranosyl-L-ascorbic acid. Han R, Liu L, Li J, et al. Appl. Microbiol. Biotechnol. 95(2), 313-20, (2012)

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Potentials and limitations of the natural antioxidants RRR-alpha-tocopherol, L-ascorbic acid and beta-carotene in cutaneous photoprotection. Fuchs J Free Radic. Biol. Med. 25(7), 848-73, (1998)

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Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Basavaraj Girennavar et al Bioorg. Med. Chem. 15, 3684-91, (2007)

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Kadsuphilols A-H, oxygenated lignans from Kadsura philippinensis. Ya-Ching Shen et al J. Nat. Prod. 70, 1139-45, (2007)

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Nociceptive behavioral responses to chemical, thermal and mechanical stimulation after unilateral, intrastriatal administration of 6-hydroxydopamine. Chudler EH Brain Res. 1213, 41-7, (2008)

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New pyrazoles incorporating pyrazolylpyrazole moiety: synthesis, anti-HCV and antitumor activity. Sayed M Riyadh et al Eur. J. Med. Chem. 45, 1042-50, (2010)

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Antioxidant enzymes mediate survival of breast cancer cells deprived of extracellular matrix. Davison CA, Durbin SM, Thau MR, et al. Cancer Res. 73(12), 3704-15, (2013)

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Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles. Bakr F Abdel-Wahab et al Eur. J. Med. Chem. 46, 1505-11, (2011)

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Biotechnological approaches for L-ascorbic acid production. Hancock RD and Viola R Trends Biotechnol. 20(7), 299-305, (2002)

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Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. Masahiko Yano et al Antimicrob. Agents Chemother. 51, 2016-27, (2007)

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Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6-hydroxydopamine lesion. Yamamoto, N Neuroscience 154(3), 1088-99, (2008)

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Vitamin C intake and breast cancer mortality in a cohort of Swedish women. Harris HR, Bergkvist L, and Wolk A Br. J. Cancer 109(1), 257-64, (2013)

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A new method for inferring hidden markov models from noisy time sequences. Kelly D, Dillingham M, Hudson A, et al. PLoS ONE 7(1), e29703, (2012)

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Green chemoselective synthesis of thiazolo[3,2-a]pyridine derivatives and evaluation of their antioxidant and cytotoxic activities. Feng Shi et al Bioorg. Med. Chem. Lett. 19, 5565-8, (2009)

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Synthesis and antioxidant properties of pulvinic acids analogues. Brice Nadal et al Bioorg. Med. Chem. 18, 7931-9, (2010)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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Ascorbic acid and its pro-oxidant activity as a therapy for tumours of oral cavity -- a systematic review. Putchala MC, Ramani P, Sherlin HJ, et al. Arch. Oral Biol. 58(6), 563-74, (2013)

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Design and synthesis of azolopyrimidoquinolines, pyrimidoquinazolines as anti-oxidant, anti-inflammatory and analgesic activities. A B A El-Gazzar et al Eur. J. Med. Chem. 44, 609-24, (2009)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Antioxidative oligostilbenes from Caragana sinica. Qinghao Jin et al Bioorg. Med. Chem. Lett. 22, 973-6, (2012)

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New acyclic nucleosides analogues as potential analgesic, anti-inflammatory, anti-oxidant and anti-microbial derived from pyrimido[4,5-b]quinolines. A B A el-Gazzar et al Eur. J. Med. Chem. 44, 1427-36, (2009)

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Dihydro-beta-agarofuran sesquiterpenes and pentacyclic triterpenoids from the root bark of Osyris lanceolata. Elizabeth M O Yeboah et al J. Nat. Prod. 73, 1151-5, (2010)

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Synthesis, biopharmaceutical characterization, antimicrobial and antioxidant activities of 1-(4'-O-?-D-glucopyranosyloxy-2'-hydroxyphenyl)-3-aryl-propane-1,3-diones. Javed Sheikh et al Eur. J. Med. Chem. 46, 1390-9, (2011)

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Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties. Clara Cena et al Bioorg. Med. Chem. 16, 5199-206, (2008)

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Design, synthesis, and examination of neuron protective properties of alkenylated and amidated dehydro-silybin derivatives. Lei Xiang Yang et al J. Med. Chem. 52, 7732-52, (2009)

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Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. Young-Whan Choi et al J. Nat. Prod. 69, 356-9, (2006)

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Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids. Dragan Ami? et al Bioorg. Med. Chem. 18, 28-35, (2010)

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Effects of low ambient temperatures and dietary vitamin C supplement on growth performance, blood parameters, and antioxidant capacity of 21-day-old broilers. Yang X, Luo YH, Zeng QF, et al. Poult. Sci. 93(4), 898-905, (2014)

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Development of an orange juice in-house reference material and its application to guarantee the quality of vitamin C determination in fruits, juices and fruit pulps. Valente A, Sanches-Silva A, Albuquerque TG, et al. Food Chem. 154, 71-7, (2014)

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The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism. Cisternas P, Silva-Alvarez C, Martínez F, et al. J. Neurochem. 129(4), 663-71, (2014)

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Oxalate at physiological urine concentrations induces oxidative injury in renal epithelial cells: effect of α-tocopherol and ascorbic acid. Thamilselvan V, Menon M, and Thamilselvan S BJU Int. 114(1), 140-50, (2014)

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Synthesis, tumor inhibitory and antioxidant activity of new polyfunctionally 2-substituted 5,6,7,8-tetrahydronaphthalene derivatives containing pyridine, thioxopyridine and pyrazolopyridine moieties. Hamdy NA, Anwar MM, Abu-Zied KM, et al. Acta Pol. Pharm. 70(6), 987-1001, (2013)

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The effect of intravenous vitamin C infusion on periprocedural myocardial injury for patients undergoing elective percutaneous coronary intervention. Wang ZJ, Hu WK, Liu YY, et al. Can. J. Cardiol. 30(1), 96-101, (2014)

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Time course of systemic oxidative stress and inflammatory response induced by an acute exposure to Residual Oil Fly Ash. Marchini T, Magnani ND, Paz ML, et al. Toxicol. Appl. Pharmacol. 274(2), 274-82, (2014)

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Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: a mechanistic approach. Abhilash PA, Harikrishnan R, and Indira M Toxicol. Appl. Pharmacol. 274(2), 215-24, (2014)

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Combination of ascorbate/epigallocatechin-3-gallate/gemcitabine synergistically induces cell cycle deregulation and apoptosis in mesothelioma cells. Martinotti S, Ranzato E, Parodi M, et al. Toxicol. Appl. Pharmacol. 274(1), 35-41, (2014)

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Merck 14,830

Beil. 18,V,5,26

Corp MSDS 1, 312:A / FT-IR 2 (1), 1190:B / FT-IR 1 (1), 702:B / FT-NMR 1 (1), 1149:C / IR-Spectra (2), 363:B / IR-Spectra (3), 409:H / NMR-Reference 2 (1), 595:A / RegBook 1 (1), 813:F / Sax 6, 325 / Sigma FT-IR 1 (1), 623:C / Structure Index 1, 127:B:6

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