Skip to Content
MilliporeSigma

B5887

Sodium butyrate

≥98.5% (GC)

Synonym(s):

Butyric acid sodium salt

Sign In to View Organizational & Contract Pricing

Select a Size

250 MG

$49.80

1 G

$171.00

5 G

$531.00

$49.80


Available to ship TODAYDetails


Ships Every 4 weeks

About This Item

Linear Formula:
CH3CH2CH2COONa
CAS Number:
Molecular Weight:
110.09
Beilstein/REAXYS Number:
3629439
EC Number:
MDL number:
UNSPSC Code:
12352107
PubChem Substance ID:
NACRES:
NA.25

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

synthetic (organic)

Quality Level

assay

≥98.5% (GC)

form

powder

storage condition

(Tightly closed. Dry.
Keep in a dry place. )

technique(s)

DNA amplification: suitable
cell based assay: suitable
inhibition assay: suitable

color

white

mp

250-253 °C (lit.)

solubility

water: 100 mg/mL, clear to slightly hazy, colorless

cation traces

Na: 19.8-22.0% (anhydrous)

suitability

suitable for DNA precipitation

application(s)

cell analysis
life science and biopharma
lipidomics

storage temp.

room temp

SMILES string

[Na+].CCCC([O-])=O

InChI

1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1

InChI key

MFBOGIVSZKQAPD-UHFFFAOYSA-M

Gene Information

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
1613600567430V900464
assay

≥98.5% (GC)

assay

-

assay

≥98% (titration)

assay

99%

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

Gene Information

mouse ... ENSMUSG00000061062(15181)

Gene Information

-

Gene Information

-

Gene Information

-

Quality Level

200

Quality Level

-

Quality Level

200

Quality Level

-

form

powder

form

-

form

solid

form

powder

solubility

water: 100 mg/mL, clear to slightly hazy, colorless

solubility

-

solubility

water: 2 mg/mL

solubility

water: 100 mg/mL, clear to slightly hazy, colorless

Application

Sodium butyrate has been used:
  • as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.[1]
  • as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.[2]
  • to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.[3]

Biochem/physiol Actions

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range.[1][2] Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.[3]

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Disclaimer

Hygroscopic

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells
Cody JJ, et al.
PLoS ONE, 9(3), e92919-e92919 (2014)
Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero
Tea JS, et al.
The Journal of Neuroscience, 30(29), 9939-9946 (2010)
Na-butyrate sustains energetic states of metabolism and t-PA productivity of CHO cells
McMurray-Beaulieu V, et al.
Journal of Bioscience and Bioengineering, 108(2), 160-167 (2009)
Ras Trokovic et al.
Stem cell research, 15(1), 254-262 (2015-06-23)
Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSC) by the forced expression of the transcription factors OCT4, SOX2, KLF4 and c-MYC. Pluripotent reprogramming appears as a slow and inefficient process because of genetic and epigenetic barriers of
Michael Bordonaro et al.
PloS one, 9(12), e115068-e115068 (2014-12-17)
Mutations in the WNT/beta-catenin pathway are present in the majority of all sporadic colorectal cancers (CRCs), and histone deacetylase inhibitors induce apoptosis in CRC cells with such mutations. This apoptosis is counteracted by (1) the signaling heterogeneity of CRC cell

Articles

Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. I would like to know which is the recommended solvent to make dilutions with Sodium butyrate B5887, they are meant for long-term storage.

    1 answer
    1. This product is soluble in water at 100 mg/mL. The filter-sterilized solution is stable for up to 2 years at 2-8°C as indicated for the 500mM prepared solution, product TR-1008.

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service