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C0750 Sigma-Aldrich

Caffeine

powder, ReagentPlus®

Synonym: 1,3,7-Trimethylxanthine

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Properties

Related Categories Alkaloid, Anti-Proliferative Agents, Antitumor Agents, Cancer Research, Cell Biology,
grade   ReagentPlus®
form   powder
color   white
mp   234-236.5 °C(lit.)
solubility   H2O: soluble15 mg/mL
Gene Information   human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369)

Description

Caution

Keep tightly sealed.

Packaging

1 kg in poly bottle

5, 100, 500 g in poly bottle

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
EV6475000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Determination of Water Content in Coffeine (Caffeine) Using Karl Fischer Titration

Caffeine tends to form lumps in the medium of the KF titration which dissolve extremely slowly during titration. The titration at 50�C is preferred. Under these conditions and the addition of formami...
Keywords: Pharmaceutical, Titrations

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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