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C0750 Sigma-Aldrich

Caffeine

powder, ReagentPlus®

Synonym: 1,3,7-Trimethylxanthine

Properties

Related Categories Alkaloid, Anti-Proliferative Agents, Antitumor Agents, Bioactive Small Molecules, C-CH,
grade   ReagentPlus®
form   powder
color   white
mp   234-236.5 °C(lit.)
solubility   H2O: soluble15 mg/mL
Gene Information   human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369)

Description

Caution

Keep tightly sealed.

Packaging

1 kg in poly bottle

5, 100, 500 g in poly bottle

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



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