EMAIL THIS PAGE TO A FRIEND

C0750 Sigma-Aldrich

Caffeine

powder, ReagentPlus®

Synonym: 1,3,7-Trimethylxanthine

Purchase

Properties

Related Categories Alkaloid, Anti-Proliferative Agents, Antitumor Agents, Cancer Research, Cell Biology,
grade   ReagentPlus®
form   powder
color   white
mp   234-236.5 °C(lit.)
solubility   H2O: soluble15 mg/mL
Gene Information   human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369)

Description

Caution

Keep tightly sealed.

Packaging

1 kg in poly bottle

5, 100, 500 g in poly bottle

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




Learn about PharmaGrade

Additional Products to Explore

Acetaminophen

BioXtra, ≥99.0%

Acetylsalicylic acid

≥99.0%, crystalline

Benzoic acid

ACS reagent, ≥99.5%

Caffeine-(<I>trimethyl</I>-<SUP>13</SUP>C<SUB>3</SUB>)

99 atom % 13C, 99% (CP)

Dichloromethane

anhydrous, ≥99.8%, contains 40-150 ppm amylene as stabilizer

Customers Also Viewed

Acetaminophen

BioXtra, ≥99.0%

Caffeine

BioXtra

Caffeine

Sigma Reference Standard, vial of 250 mg

Caffeine-(<I>trimethyl</I>-<SUP>13</SUP>C<SUB>3</SUB>)

99 atom % 13C, 99% (CP)

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
UN 1544 6.1/PG 3
WGK Germany 
1
RTECS 
EV6475000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Determination of Water Content in Coffeine (Caffeine) Using Karl Fischer Titration

Caffeine tends to form lumps in the medium of the KF titration which dissolve extremely slowly during titration. The titration at 50�C is preferred. Under these conditions and the addition of formami...
Keywords: Pharmaceutical, Titrations

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors. Shafer, S.H., et al. Biochem. Pharmacol. 56, 1229-1236, (1998)

Loading...


In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation. Islam, M.S., et al. Proc. Natl. Acad. Sci. U. S. A. 95, 6145-6150, (1998)

Loading...


Caffeine modulates heat shock induced apoptosis in the human promyelocytic leukemia cell line HL-60. Poe, B.S., and O'Neill, K.L. Cancer Lett. 121, 1-6, (1997)

Loading...


Caffeine and the olfactory bulb. Hadfield, M.G. Mol. Neurobiol. 15, 31-39, (1997)

Loading...


Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Ferre, S., et al. Trends Neurosci. 20, 482-487, (1997)

Loading...


p53-independent anisomycin induced G1 arrest and apoptosis in L1210 cell lines. He, A.W., and Cory, J.G. Anticancer Res. 19, 421-428, (1999)

Loading...


DNA damage-associated cell cycle and cell death control is differentially modulated by caffeine in clones with p53 mutations. Takagi, M., et al. Leukemia 13, 70-77, (1999)

Loading...


Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

Loading...


Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. Sinha RA, Farah BL, Singh BK, et al. Hepatology 59(4), 1366-80, (2014)

Loading...


Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections. Peng, J.; et al. J. Med. Chem. 53, 61, (2010)

Loading...


The coffee genome provides insight into the convergent evolution of caffeine biosynthesis. Denoeud F, Carretero-Paulet L, Dereeper A, et al. Science 345(6201), 1181-4, (2014)

Loading...


Calnexin silencing in mouse neonatal cardiomyocytes induces Ca2+ cycling defects, ER stress, and apoptosis. Bousette N, Abbasi C, Chis R, et al. J. Cell Physiol. 229(3), 374-83, (2014)

Loading...


Identifying off-target effects and hidden phenotypes of drugs in human cells. Marnie L MacDonald et al Nat. Chem. Biol. 2, 329-37, (2006)

Loading...


Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

Loading...


Identifying key non-volatile compounds in ready-to-drink green tea and their impact on taste profile. Yu P, Yeo AS, Low MY, et al. Food Chem. 155, 9-16, (2014)

Loading...


Immunomodulatory effects of caffeine: friend or foe? Horrigan LA, Kelly JP, and Connor TJ Pharmacol. Ther. 111(3), 877-92, (2006)

Loading...


Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. Giorgio Ottaviani et al J. Med. Chem. 49, 3948-54, (2006)

Loading...


Black tea lowers the rate of blood pressure variation: a randomized controlled trial. Hodgson JM, Croft KD, Woodman RJ, et al. Am. J. Clin. Nutr. 97(5), 943-50, (2013)

Loading...


Amplification of steroid-mediated SP-B expression by physiological levels of caffeine. Fehrholz M, Hütten M, Kramer BW, et al. Am. J. Physiol. Lung Cell. Mol. Physiol. 306(1), L101-9, (2014)

Loading...


QSAR study on permeability of hydrophobic compounds with artificial membranes. Masaaki Fujikawa et al Bioorg. Med. Chem. 15, 3756-67, (2007)

Loading...


Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. Pelayo Camps et al J. Med. Chem. 52, 5365-79, (2009)

Loading...


Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. José Marco-Contelles et al J. Med. Chem. 52, 2724-32, (2009)

Loading...


PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2. McDonagh EM, Boukouvala S, Aklillu E, et al. Pharmacogenet. Genomics 24(8), 409-25, (2014)

Loading...


Impact of daily high-dose caffeine exposure on developing white matter of the immature ovine brain. Atik A, Cheong J, Harding R, et al. Pediatr. Res. 76(1), 54-63, (2014)

Loading...


Biomarker measurements in a coastal fish-eating population environmentally exposed to organochlorines. Ayotte P, Dewailly E, Lambert GH, et al. Environ. Health Perspect. 113(10), 1318-24, (2005)

Loading...


Catechin- and caffeine-rich teas for control of body weight in humans. Hursel R and Westerterp-Plantenga MS Am. J. Clin. Nutr. 98(6 Suppl), 1682S-1693S, (2013)

Loading...


N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles. Morteza Malakoutikhah et al J. Med. Chem. 53, 2354-63, (2010)

Loading...


Long-term coffee consumption in relation to fracture risk and bone mineral density in women. Hallström H, Byberg L, Glynn A, et al. Am. J. Epidemiol. 178(6), 898-909, (2013)

Loading...


Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

Loading...


In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Giorgio Ottaviani et al J. Med. Chem. 50, 742-8, (2007)

Loading...


New insights into the mechanism of light modulated signaling by heterotrimeric G-proteins: ENVOY acts on gna1 and gna3 and adjusts cAMP levels in Trichoderma reesei (Hypocrea jecorina). Tisch D Fungal Genet. Biol. 48(6), 631-40, (2011)

Loading...


Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

Loading...


Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation. Zelensky AN, Sanchez H, Ristic D, et al. Nucleic Acids Res. 41(13), 6475-89, (2013)

Loading...


Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Schaefer A Neuron 64(5), 678-91, (2009)

Loading...


Pharmacogenetics of CYP1A2 activity and inducibility in smokers and exsmokers. Dobrinas M, Cornuz J, and Eap CB Pharmacogenet. Genomics 23(5), 286-92, (2013)

Loading...


Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

Loading...


Use of caffeinated substances and risk of crashes in long distance drivers of commercial vehicles: case-control study. Sharwood LN, Elkington J, Meuleners L, et al. BMJ 346, f1140, (2013)

Loading...


Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

Loading...


Toward an optimal blood-brain barrier shuttle by synthesis and evaluation of peptide libraries. Morteza Malakoutikhah et al J. Med. Chem. 51, 4881-9, (2008)

Loading...


Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Sreekumar A, Poisson LM, Rajendiran TM, et al. Nature 457(7231), 910-4, (2009)

Loading...


Critical review of dietary caffeine and blood pressure: a relationship that should be taken more seriously. James JE Psychosom. Med. 66(1), 63-71, (2004)

Loading...


Coffee drinking and cutaneous melanoma risk in the NIH-AARP diet and health study. Loftfield E, Freedman ND, Graubard BI, et al. J. Natl. Cancer Inst. 107(2), doi:10.1093/jnci/dju421, (2015)

Loading...


Derivation and validation of homocysteine score in u.s. Men and women. Jung S, Je Y, Giovannucci EL, et al. J. Nutr. 145(1), 96-104, (2015)

Loading...


Caffeine as an analgesic adjuvant for acute pain in adults. Derry CJ, Derry S, and Moore RA Cochrane Database Syst. Rev. 12, CD009281, (2014)

Loading...


[How much coffee is healthy?]. Etter F Praxis (Bern 1994) 103(25), 1531-2, (2014)

Loading...


Characterization of cadmium plasma membrane transport in gills of a mangrove crab Ucides cordatus. Ortega P, Custódio MR, and Zanotto FP Aquat. Toxicol. 157, 21-9, (2014)

Loading...


The new rules for coffee and wine drinkers. Healthful? In moderation, perhaps. In vast quantities? Dream on. Consum. Rep. 79(12), 19, (2014)

Loading...


Caffeine intake and the risk of kidney stones. Ferraro PM, Taylor EN, Gambaro G, et al. Am. J. Clin. Nutr. 100(6), 1596-603, (2014)

Loading...


Association of early caffeine administration and neonatal outcomes in very preterm neonates. Lodha A, Seshia M, McMillan DD, et al. JAMA Pediatr. 169(1), 33-8, (2015)

Loading...


Evaluation on activity of cytochrome p450 enzymes in turbot via a probe drug cocktail. Chang ZQ, Li J, and Zhai QQ J. Aquat. Anim. Health 26(4), 272-7, (2014)

Loading...


Caffeine exposure alters cardiac gene expression in embryonic cardiomyocytes. Fang X, Mei W, Barbazuk WB, et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(12), R1471-87, (2014)

Loading...


Night shift work at specific age ranges and chronic disease risk factors. Ramin C, Devore EE, Wang W, et al. Occup. Environ. Med. 72(2), 100-7, (2015)

Loading...


The buzz: is caffeine addiction real? Johns Hopkins Med. Lett. Health After 50 26(6), 6, (2014)

Loading...


Influence of caffeine on the expression of human chorionic gonadotropin and progesterone receptors in human trophoblast cell lines. Lee BH, Park TC, and Lee HJ Acta Obstet. Gynecol. Scand. 93(12), 1334-5, (2014)

Loading...


Inverse associations of total and decaffeinated coffee with liver enzyme levels in National Health and Nutrition Examination Survey 1999-2010. Xiao Q, Sinha R, Graubard BI, et al. Hepatology 60(6), 2091-8, (2014)

Loading...


Pharmacological interventions for sleepiness and sleep disturbances caused by shift work. Liira J, Verbeek JH, Costa G, et al. Cochrane Database Syst. Rev. 8, CD009776, (2014)

Loading...


Alkaloids and athlete immune function: caffeine, theophylline, gingerol, ephedrine, and their congeners. Senchina DS, Hallam JE, Kohut ML, et al. Exerc. Immunol. Rev. 20, 68-93, (2014)

Loading...


[Caffeine in analgesics--myth or medicine?]. Petersen KU MMW Fortschr. Med. 155 Suppl 4, 109-14, (2013)

Loading...


[Adverse effects of energy drinks]. Chevillotte J Rev. Infirm. 196, 7, (2013)

Loading...


Why so jittery? More and more products contain more and more caffeine. Fischetti M Sci. Am. 309(5), 82, (2013)

Loading...


[The effect of coffee on blood pressure at healthy subjects]. Bielesz K, Strzelczyk W, Poniewaz M, et al. Pol. Merkur. Lekarski 35(207), 133-5, (2013)

Loading...


[Caffeine protects against accidents during long automobile trips]. Holzgreve H MMW Fortschr. Med. 155(12), 29, (2013)

Loading...


[Caffe lungo]. Mauron A Rev. Med. Suisse 9(389), 1234, (2013)

Loading...


Too much of a good thing. Consum. Rep. 78(3), 7, (2013)

Loading...


Simultaneous in vivo phenotyping of CYP enzymes. Ghassabian S and Murray M Methods Mol. Biol. 987, 261-7, (2013)

Loading...


[Convulsive crisis in Tramadol and caffeine abusers: about 8 cases and review of the literature]. Maiga DD, Seyni H, Sidikou A, et al. Pan Afr. Med. J. 13, 24, (2012)

Loading...


Combined butalbital/acetaminophen/caffeine overdose: case files of the Robert Wood Johnson Medical School Toxicology Service. Bryczkowski C and Geib AJ J. Med. Toxicol. 8(4), 424-31, (2012)

Loading...


[Caffeine--common ingredient in a diet and its influence on human health]. Wierzejska R Rocz. Panstw. Zakl. Hig. 63(2), 141-7, (2012)

Loading...


Boiled or filtered coffee? Effects of coffee and caffeine on cholesterol, fibrinogen and C-reactive protein. Rodrigues IM and Klein LC Toxicol. Rev. 25(1), 55-69, (2006)

Loading...


Anesthesia concerns for children with tuberous sclerosis. Septer S, Thompson ES, and Willemsen-Dunlap A AANA J. 74(3), 219-25, (2006)

Loading...


Spectrophotometric determination of drugs with iodine. Karuna T, et al. J. Sci. Ind. Res. 65(10), 808, (2006)

Loading...


Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. Mariana P Arce et al J. Med. Chem. 52, 7249-57, (2009)

Loading...


Coffee and health: a review of recent human research. Higdon JV and Frei B Crit. Rev. Food Sci. Nutr 46(2), 101-23, (2006)

Loading...


The Japanese toxicogenomics project: application of toxicogenomics. Takeki Uehara et al Mol. Nutr. Food. Res. 54, 218-27, (2010)

Loading...


Intake of caffeinated, carbonated, or citrus beverage types and development of lower urinary tract symptoms in men and women. Maserejian NN, Wager CG, Giovannucci EL, et al. Am. J. Epidemiol. 177(12), 1399-410, (2013)

Loading...


Hologram QSAR model for the prediction of human oral bioavailability. Tiago L Moda et al Bioorg. Med. Chem. 15, 7738-45, (2007)

Loading...


Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Larson AM, Polson J, Fontana RJ, et al. Hepatology 42(6), 1364-72, (2005)

Loading...


Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. Charrier, J.-D.; et al. J. Med. Chem. 54, 2320, (2011)

Loading...


Caffeine in floral nectar enhances a pollinator's memory of reward. Wright GA, Baker DD, Palmer MJ, et al. Science 339(6124), 1202-4, (2013)

Loading...


Biophysical mapping of the adenosine A2A receptor. Andrei Zhukov et al J. Med. Chem. 54, 4312-23, (2011)

Loading...


Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

Loading...


Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies. Xiaoan Wen et al J. Med. Chem. 51, 3540-54, (2008)

Loading...


1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. Thomas Borrmann et al J. Med. Chem. 52, 3994-4006, (2009)

Loading...


Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

Loading...


Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential. Dennis J Pelletier et al J. Chem. Inf. Model. 47, 1196-205, (2007)

Loading...


A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation. Gianpaolo Chiriano et al Eur. J. Med. Chem. 48, 206-13, (2012)

Loading...


How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Alex Avdeef et al J. Med. Chem. 53, 3566-84, (2010)

Loading...


Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study. Dik VK, Bueno-de-Mesquita HB, Van Oijen MG, et al. Int. J. Cancer 135(2), 401-12, (2014)

Loading...


Caffeine as an attention enhancer: reviewing existing assumptions. Einöther SJ and Giesbrecht T Psychopharmacology 225(2), 251-74, (2013)

Loading...


Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

Loading...


Trends in caffeine use and association between clinical outcomes and timing of therapy in very low birth weight infants. Dobson NR, Patel RM, Smith PB, et al. J. Pediatr. 164(5), 992-998.e3, (2014)

Loading...


High coffee intake, but not caffeine, is associated with reduced estrogen receptor negative and postmenopausal breast cancer risk with no effect modification by CYP1A2 genotype. Lowcock EC, Cotterchio M, Anderson LN, et al. Nutr. Cancer 65(3), 398-409, (2013)

Loading...


N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. Gema C González-Muñoz et al Eur. J. Med. Chem. 46, 2224-35, (2011)

Loading...


Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation. Wang L, Myles RC, De Jesus NM, et al. Circ. Res. 114(9), 1410-21, (2014)

Loading...


Do energy drinks contain active components other than caffeine? McLellan TM and Lieberman HR Nutr. Rev. 70(12), 730-44, (2012)

Loading...


Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine. Gronwald W, Klein MS, Zeltner R, et al. Kidney Int. 79(11), 1244-53, (2011)

Loading...


Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors. Roberta Ettari et al J. Med. Chem. 52, 2157-60, (2009)

Loading...


Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model. Miriam Redondo et al Eur. J. Med. Chem. 47, 175-85, (2012)

Loading...


Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies. Wilkinson SC, Maas WJ, Nielsen JB, et al. Int. Arch. Occup. Environ. Health 79(5), 405-13, (2006)

Loading...


Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Hong Wan et al J. Med. Chem. 52, 1693-700, (2009)

Loading...


Studies on the interaction of caffeine with bovine hemoglobin. Yan-Qing Wang et al Eur. J. Med. Chem. 44, 2100-5, (2009)

Loading...


Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring. Wang L, Shen L, Ping J, et al. Toxicol. Lett. 224(3), 311-8, (2014)

Loading...


Synthesis and antioxidant properties of novel N-methyl-1,3,4-thiadiazol-2-amine and 4-methyl-2H-1,2,4-triazole-3(4H)-thione derivatives of benzimidazole class. Canan Ku? et al Bioorg. Med. Chem. 16, 4294-303, (2008)

Loading...


Determination of quality constituents in the young leaves of albino tea cultivars. Feng L, Gao MJ, Hou RY, et al. Food Chem. 155, 98-104, (2014)

Loading...


Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies. Jiang W, Wu Y, and Jiang X Gynecol. Oncol. 129(3), 620-9, (2013)

Loading...


Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced ?-amyloid aggregation inhibitors. Huang Tang et al Eur. J. Med. Chem. 46, 4970-9, (2011)

Loading...


Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors. Darvas M and Palmiter RD Proc. Natl. Acad. Sci. U. S. A. 106(34), 14664-9, (2009)

Loading...


A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Beckerman R Genes Dev. 23(11), 1364-77, (2009)

Loading...


Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. Hein J J. Virol. 83(1), 117-27, (2009)

Loading...


Prediction of drug intestinal absorption by new linear and non-linear QSPR. Alan Talevi et al Eur. J. Med. Chem. 46, 218-28, (2011)

Loading...


Epidemiologic evidence of a relationship between tea, coffee, or caffeine consumption and cognitive decline. Arab L, Khan F, and Lam H Adv. Nutr. 4(1), 115-22, (2013)

Loading...


Topically applied caffeine induces miosis in the ketamine/xylazine anesthetized rat. Kronschläger M, Yu Z, Talebizadeh N, et al. Exp. Eye Res. 127, 179-83, (2014)

Loading...


Dual inhibition of monoamine oxidase B and antagonism of the adenosine A(2A) receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues. Judey Pretorius et al Bioorg. Med. Chem. 16, 8676-84, (2008)

Loading...


Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator. George P Lahm et al Bioorg. Med. Chem. Lett. 17, 6274-9, (2007)

Loading...


Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Larry J Jolivette et al J. Pharm. Pharm. Sci. 94, 1467-83, (2005)

Loading...


Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease. Gonçalves N, Simões AT, Cunha RA, et al. Ann. Neurol. 73(5), 655-66, (2013)

Loading...


Validation of a screening questionnaire for a human milk bank to determine the presence of illegal drugs, nicotine, and caffeine. Escuder-Vieco D, Garcia-Algar Ó, Pichini S, et al. J. Pediatr. 164(4), 811-4, (2014)

Loading...


Distinctive anatomical and physiological features of migraine aura revealed by 18 years of recording. Hansen JM, Baca SM, Vanvalkenburgh P, et al. Brain 136(Pt 12), 3589-95, (2013)

Loading...


A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

Loading...


Occurrence and fate of PPCPs and correlations with water quality parameters in urban riverine waters of the Pearl River Delta, South China. Yang X, Chen F, Meng F, et al. Environ. Sci. Pollut. Res. Int. 20(8), 5864-75, (2013)

Loading...


Internal standard application to dried blood spots by spraying: investigation of the internal standard distribution. Zimmer D, Hassler S, Betschart B, et al. Bioanalysis 5(6), 711-9, (2013)

Loading...


Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase. Jun Chen et al Bioorg. Med. Chem. Lett. 16, 2915-9, (2006)

Loading...


Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors. Xiaoan Wen et al Bioorg. Med. Chem. Lett. 16, 722-6, (2006)

Loading...


New prognostic scoring model for liver transplantation in patients with non-acetaminophen-related fulminant hepatic failure. Miyake Y, Sakaguchi K, Iwasaki Y, et al. Transplantation 80(7), 930-6, (2005)

Loading...


Changes in taste neurons support the emergence of an adaptive behavior in cockroaches. Wada-Katsumata A, Silverman J, and Schal C Science 340(6135), 972-5, (2013)

Loading...


Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Feixiong Cheng et al Eur. J. Med. Chem. 45, 3459-71, (2010)

Loading...


Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: a review. Rivera-Oliver M and Díaz-Ríos M Life Sci. 101(1-2), 1-9, (2014)

Loading...


Pentacyclic triterpenes. Part 1: the first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases. Xiaoan Wen et al Bioorg. Med. Chem. Lett. 15, 4944-8, (2005)

Loading...


Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Huang Tang et al Bioorg. Med. Chem. Lett. 22, 2257-61, (2012)

Loading...


Calcium release from intra-axonal endoplasmic reticulum leads to axon degeneration through mitochondrial dysfunction. Villegas R, Martinez NW, Lillo J, et al. J. Neurosci. 34(21), 7179-89, (2014)

Loading...


Regulatory T-cell modulation by green tea in chronic lymphocytic leukemia. D'Arena G, Simeon V, De Martino L, et al. Int. J. Immunopathol. Pharmacol. 26(1), 117-25, (2013)

Loading...


Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase. Keguang Cheng et al J. Nat. Prod. 71, 1877-80, (2008)

Loading...


A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata. Patrick Vandeputte et al Antimicrob. Agents Chemother. 52, 3701-9, (2008)

Loading...


Caffeine does not increase the risk of atrial fibrillation: a systematic review and meta-analysis of observational studies. Caldeira D, Martins C, Alves LB, et al. Heart 99(19), 1383-9, (2013)

Loading...


Pentacyclic triterpenes. Part 5: synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases. Xiaoan Wen et al Bioorg. Med. Chem. Lett. 17, 5777-82, (2007)

Loading...


Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis. Ping J, Wang JF, Liu L, et al. Toxicology 321, 53-61, (2014)

Loading...


Coffee consumption and total mortality: a meta-analysis of twenty prospective cohort studies. Je Y and Giovannucci E Br. J. Nutr. 111(7), 1162-73, (2014)

Loading...


Effect of smoking and caffeine consumption on polybrominated diphenyl ethers (PBDE) and polybrominated biphenyls (PBB). Jain RB J. Toxicol. Environ. Health A 76(8), 515-32, (2013)

Loading...


Urinary inflammatory mediators and inhalation of hypertonic saline in children. Mai XM, Böttcher MF, Bruhammar M, et al. Allergy 60(1), 60-4, (2005)

Loading...


Caffeine intake in children in the United States and 10-y trends: 2001-2010. Ahluwalia N, Herrick K, Moshfegh A, et al. Am. J. Clin. Nutr. 100(4), 1124-32, (2014)

Loading...


Urinary 3-bromotyrosine and 3-chlorotyrosine concentrations in asthmatic patients: lack of increase in 3-bromotyrosine concentration in urine and plasma proteins in aspirin-induced asthma after intravenous aspirin challenge. Mita H, Higashi N, Taniguchi M, et al. Clin. Exp. Allergy 34(6), 931-8, (2004)

Loading...


Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. Pu Zhang et al J. Nat. Prod. 72, 1414-8, (2009)

Loading...


Determination of log D via automated microfluidic liquid-liquid extraction. Muhammad Alimuddin et al J. Med. Chem. 51, 5140-2, (2008)

Loading...


Novel N-methylated 8-oxoisoguanines from Pacific sponges with diverse neuroactivities. Tsuyoshi Sakurada et al J. Med. Chem. 53, 6089-99, (2010)

Loading...


2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Anja B Scheiff et al Bioorg. Med. Chem. 18, 2195-203, (2010)

Loading...


Screening for long-lived genes identifies Oga1, a guanine-quadruplex associated protein that affects the chronological lifespan of the fission yeast Schizosaccharomyces pombe. Ohtsuka H, Ogawa S, Kawamura H, et al. Mol. Genet. Genomics 288(5-6), 285-95, (2013)

Loading...


Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. Nandita Sinha et al Eur. J. Med. Chem. 46, 618-30, (2011)

Loading...


The effect of black tea and caffeine on regional cerebral blood flow measured with arterial spin labeling. Vidyasagar R, Greyling A, Draijer R, et al. J. Cereb. Blood Flow Metab. 33(6), 963-8, (2013)

Loading...


Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

Loading...


Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease. Jaiswal, MK BMC Neurosci. 10, 64, (2009)

Loading...


Synthesis of hybrid molecules of caffeine and eudistomin D and its effects on adenosine receptors. Kengo Ohshita et al Bioorg. Med. Chem. 15, 3235-40, (2007)

Loading...


The buzz on caffeine in invertebrates: effects on behavior and molecular mechanisms. Mustard JA Cell. Mol. Life Sci. 71(8), 1375-82, (2014)

Loading...


Graphene matrix for signal enhancement in ambient plasma assisted laser desorption ionization mass spectrometry. Chang C, Li X, Bai Y, et al. Talanta 114, 54-9, (2013)

Loading...


Acute effects of tea consumption on attention and mood. Einöther SJ and Martens VE Am. J. Clin. Nutr. 98(6 Suppl), 1700S-1708S, (2013)

Loading...


Plasmalemmal sodium-calcium exchanger shapes the calcium and exocytotic signals of chromaffin cells at physiological temperature. Padín JF, Fernández-Morales JC, Olivares R, et al. Am. J. Physiol. Cell Physiol. 305(2), C160-72, (2013)

Loading...


Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer. Uccella S, Mariani A, Wang AH, et al. Br. J. Cancer 109(7), 1908-13, (2013)

Loading...


Prospective study of the relationship between coffee and tea with colorectal cancer risk: the PLCO Cancer Screening Trial. Dominianni C, Huang WY, Berndt S, et al. Br. J. Cancer 109(5), 1352-9, (2013)

Loading...


Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data. Elena Dreassi et al Eur. J. Med. Chem. 44, 3712-7, (2009)

Loading...


Inhibition of monoamine oxidase by (E)-styrylisatin analogues. Elizna M Van der Walt et al Bioorg. Med. Chem. Lett. 19, 2509-13, (2009)

Loading...


Synthesis of eudistomin D analogues and its effects on adenosine receptors. Haruaki Ishiyama et al Bioorg. Med. Chem. 16, 3825-30, (2008)

Loading...


Tea catechins and flavonoids from the leaves of Camellia sinensis inhibit yeast alcohol dehydrogenase. Md Maniruzzaman Manir et al Bioorg. Med. Chem. 20, 2376-81, (2012)

Loading...


Application of physiologically-based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients. Gajewska M, Worth A, Urani C, et al. Toxicol. Lett. 227(3), 189-202, (2014)

Loading...


Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans. Sachse KT, Jackson EK, Wisniewski SR, et al. J. Cereb. Blood Flow Metab. 28(2), 395-401, (2008)

Loading...


Hepatic veno-occlusive disease due to tacrolimus in a single-lung transplant patient. Shah S, Budev M, Blazey H, et al. Eur. Respir. J. 27(5), 1066-8, (2006)

Loading...


Separation, pre-concentration, and HPLC analysis of methylxanthines in urine samples. Zydroń M, Baranowski J, and Baranowska I J. Sep. Sci. 27(14), 1166-72, (2004)

Loading...


Chronological effects of rifampicin discontinuation on cytochrome P450 activity in healthy Japanese volunteers, using the cocktail method. Inui N, Akamatsu T, Uchida S, et al. Clin. Pharmacol. Ther. 94(6), 702-8, (2013)

Loading...


Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions: thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors. Paola Gilli et al J. Med. Chem. 48, 2026-35, (2005)

Loading...


Caffeine and modafinil promote adult neuronal cell proliferation during 48 h of total sleep deprivation in rat dentate gyrus. Sahu S, Kauser H, Ray K, et al. Exp. Neurol. 248, 470-81, (2013)

Loading...


Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxicol. Mech. Methods 18, 217-27, (2008)

Loading...


First-principle, structure-based prediction of hepatic metabolic clearance values in human. Haiyan Li et al Eur. J. Med. Chem. 44, 1600-6, (2009)

Loading...


N9-benzyl-substituted 1,3-dimethyl- and 1,3-dipropyl-pyrimido[2,1-f]purinediones: synthesis and structure-activity relationships at adenosine A1 and A2A receptors. Anna Drabczyńska et al Bioorg. Med. Chem. 15, 5003-17, (2007)

Loading...


Long-term alcohol and caffeine intake and risk of sudden cardiac death in women. Bertoia ML, Triche EW, Michaud DS, et al. Am. J. Clin. Nutr. 97(6), 1356-63, (2013)

Loading...


Collision-induced dissociation studies of caffeine in positive electrospray ionisation mass spectrometry using six deuterated isotopomers and one N1-ethylated homologue. Bier D, Hartmann R, and Holschbach M Rapid Commun. Mass Spectrom. 27(8), 885-95, (2013)

Loading...


Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

Loading...


Selected health and behavioral effects related to the use of caffeine. Lamarine RJ J. Community Health 19(6), 449-66, (1994)

Loading...


QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

Loading...


Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine. José R Fernández et al Bioorg. Med. Chem. 18, 6748-55, (2010)

Loading...


Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: structure-activity relationships as adenosine A(1) and A(2A) receptor ligands. Anna Drabczyńska et al Bioorg. Med. Chem. 15, 6956-74, (2007)

Loading...


Efficacy of activated charcoal administered more than four hours after acetaminophen overdose. Spiller HA, Winter ML, Klein-Schwartz W, et al. J. Emerg. Med. 30(1), 1-5, (2006)

Loading...


Hypnic headache and caffeine. Holle D and Obermann M Expert Rev. Neurother. 12(9), 1125-32, (2012)

Loading...


Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids. Alexander C Roy et al Bioorg. Med. Chem. Lett. 20, 141-4, (2010)

Loading...


Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

Loading...


Cardiovascular responses to caffeine by gender and pubertal stage. Temple JL, Ziegler AM, Graczyk A, et al. Pediatrics 134(1), e112-9, (2014)

Loading...


Proposed actions for the US Food and Drug Administration to implement to minimize adverse effects associated with energy drink consumption. Thorlton J, Colby DA, and Devine P Am. J. Public Health 104(7), 1175-80, (2014)

Loading...


Impaired mutagenic activities of MPDP(+) (1-methyl-4-phenyl-2,3-dihydropyridinium) and MPP(+) (1-methyl-4-phenylpyridinium) due to their interactions with methylxanthines. Katarzyna Ulanowska et al Bioorg. Med. Chem. 15, 5150-7, (2007)

Loading...


Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis. Camfield DA, Stough C, Farrimond J, et al. Nutr. Rev. 72(8), 507-22, (2014)

Loading...


Effects of restricted caffeine intake by mother on fetal, neonatal and pregnancy outcome. Jahanfar S and Jaafar SH Cochrane Database Syst. Rev. 2, CD006965, (2013)

Loading...


Activation and inhibition of CTP synthase from Trypanosoma brucei, the causative agent of African sleeping sickness. Craig H Steeves et al Bioorg. Med. Chem. Lett. 21, 5188-90, (2011)

Loading...


Caffeine reduces myocardial blood flow during exercise. Higgins JP and Babu KM Am. J. Med. 126(8), 730.e1-8, (2013)

Loading...


Detection of caffeine in tea, instant coffee, green tea beverage, and soft drink by direct analysis in real time (DART) source coupled to single-quadrupole mass spectrometry. Wang L, Zhao P, Zhang F, et al. J. AOAC Int. 96(2), 353-6, (2013)

Loading...


Terpenoids. III: Synthesis and biological evaluation of 23-hydroxybetulinic acid derivatives as novel inhibitors of glycogen phosphorylase. Peiqing Zhu et al Bioorg. Med. Chem. Lett. 19, 6966-9, (2009)

Loading...


Glycogen phosphorylase inhibitory effects of 2-oxo-1,2-dihydropyridin-3-yl amide derivatives. N David Karis et al Bioorg. Med. Chem. 17, 4724-33, (2009)

Loading...


Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors. Haruaki Ishiyama et al Bioorg. Med. Chem. 17, 4280-4, (2009)

Loading...


Molecular imaging of the ATM kinase activity. Williams TM, Nyati S, Ross BD, et al. Int. J. Radiat. Oncol. Biol. Phys. 86(5), 969-77, (2013)

Loading...


Modifying effect of N-acetyltransferase 2 genotype on the association between systemic lupus erythematosus and consumption of alcohol and caffeine-rich beverages. Kiyohara C, Washio M, Horiuchi T, et al. Arthritis Care Res. (Hoboken.) 66(7), 1048-56, (2014)

Loading...


Eudistomin D and penaresin derivatives as modulators of ryanodine receptor channels and sarcoplasmic reticulum Ca2+ ATPase in striated muscle. Diaz-Sylvester PL, Porta M, Juettner VV, et al. Mol. Pharmacol. 85(4), 564-75, (2014)

Loading...


Natural attenuation of pharmaceuticals and an illicit drug in a laboratory column experiment. Greenhagen AM, Lenczewski ME, and Carroll M Chemosphere 115, 13-9, (2014)

Loading...


Systematic review of randomised controlled trials of the effects of caffeine or caffeinated drinks on blood glucose concentrations and insulin sensitivity in people with diabetes mellitus. Whitehead N and White H J. Hum. Nutr. Diet. 26(2), 111-25, (2013)

Loading...


The MP65 gene is required for cell wall integrity, adherence to epithelial cells and biofilm formation in Candida albicans. Sandini S BMC Microbiol. 11, 106, (2011)

Loading...


Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid. Liying Zhang et al Bioorg. Med. Chem. Lett. 22, 1036-9, (2012)

Loading...


Caffeine intake and atrial fibrillation incidence: dose response meta-analysis of prospective cohort studies. Cheng M, Hu Z, Lu X, et al. Can. J. Cardiol. 30(4), 448-54, (2014)

Loading...


Supplement use by UK-based British Army soldiers in training. Casey A, Hughes J, Izard RM, et al. Br. J. Nutr. 112(7), 1175-84, (2014)

Loading...


A method for the measurement of plasma hydroxyeicosatetraenoic acid levels. Chavis, C., et al. Anal. Biochem. 271, 105-108, (1999)

Loading...


Efficient synthesis and biological evaluation of epiceanothic acid and related compounds. Pu Zhang et al Bioorg. Med. Chem. Lett. 21, 338-41, (2011)

Loading...


Caffeine citrate: when and for how long. A literature review. Picone S, Bedetta M, and Paolillo P J. Matern. Fetal. Neonatal. Med. 25 Suppl 3, 11-4, (2012)

Loading...


Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Pil H Lee et al Bioorg. Med. Chem. Lett. 20, 69-73, (2010)

Loading...


Use of methylxanthine therapies for the treatment and prevention of apnea of prematurity. Schoen K, Yu T, Stockmann C, et al. Paediatr. Drugs 16(2), 169-77, (2014)

Loading...


Determination of catechins and caffeine in camillia sinensis raw materials, extracts, and dietary supplements by HPLC-uv: single-laboratory validation. Roman MC J. AOAC Int. 96(5), 933-41, (2013)

Loading...


An RP-HPLC-UV method with SPE for cefotaxime in all-in-one total parenteral nutritional admixtures: application to stability studies. Iqbal MS, Bahari MB, Darwis Y, et al. J. AOAC Int. 96(2), 290-4, (2013)

Loading...


Simultaneous determination of L-tyrosine and caffeine based on their electrocatalytic oxidation at a 4-tert-butylcalix[6] arene-modified carbon paste electrode. Srivastava AK and Gaichore RR J. AOAC Int. 96(1), 133-41, (2013)

Loading...


N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle. da Silva JS, Pereira SL, Maia Rdo C, et al. Life Sci. 94(1), 30-6, (2014)

Loading...


Fatal caffeine overdose: a case report and review of literature. Jabbar SB and Hanly MG Am. J. Forensic Med. Pathol. 34(4), 321-4, (2013)

Loading...


Caffeinated-beverage consumption and its association with socio-demographic characteristics and self-perceived academic stress in first and second year students at the University of Puerto Rico Medical Sciences Campus (UPR-MSC). Ríos JL, Betancourt J, Pagán I, et al. P. R. Health Sci. J. 32(2), 95-100, (2013)

Loading...


Caffeine gum minimizes sleep inertia. Newman RA, Kamimori GH, Wesensten NJ, et al. Percept. Mot. Skills 116(1), 280-93, (2013)

Loading...


Actual treatment of overactive bladder and urge urinary incontinence. Cornu JN Minerva Urol. Nefrol. 65(1), 21-35, (2013)

Loading...


Comparison of maternal and fetal blood levels of caffeine and its metabolite. A pilot study. Wierzejska R, Jarosz M, Siuba M, et al. Ginekol. Pol. 85(7), 500-3, (2014)

Loading...


[Vasobral in the treatment of brain lesions: views of physicians and patients]. Kamchatnov PR Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova 113(1), 23-5, (2013)

Loading...


Botany. A wake-up call with coffee. Zamir D Science 345(6201), 1124, (2014)

Loading...


The management of substance abuse in the critically ill. Patel G Dis. Mon. 60(8), 429-41, (2014)

Loading...


Severe hypertension related to caffeinated coffee and tranylcypromine: a case report. van der Hoeven N, Visser I, Schene A, et al. Ann. Intern. Med. 160(9), 657-8, (2014)

Loading...


Timing of caffeine therapy in very low birth weight infants. Schmidt B, Davis PG, and Roberts RS J. Pediatr. 164(5), 957-8, (2014)

Loading...


How does coffee prevent liver fibrosis? Biological plausibility for recent epidemiological observations. Dranoff JA, Feld JJ, Lavoie EG, et al. Hepatology 60(2), 464-7, (2014)

Loading...


Genetics of drug-induced hepatotoxicity toxicity in Gilbert's syndrome. Raza A, Vierling J, and Hussain KB Am. J. Gastroenterol. 108(12), 1936-7, (2013)

Loading...


Caffeine-induced rhabdomyolysis. Golcuk Y, Ozsarac M, Golcuk B, et al. Am. J. Emerg. Med. 32(1), 100, (2014)

Loading...


Energy drinks: cause for concern or scaremongering? Roehr B BMJ 347, f6343, (2013)

Loading...


Drinking coffee burns hepatic fat by inducing lipophagy coupled with mitochondrial β-oxidation. Ding WX Hepatology 59(4), 1235-8, (2014)

Loading...


Caffeine overdose resulting in severe rhabdomyolysis and acute renal failure. Campana C, Griffin PL, and Simon EL Am. J. Emerg. Med. 32(1), 111.e3-4, (2014)

Loading...


Energy drinks and alcohol: research supported by industry may be downplaying harms. Miller P BMJ 347, f5345, (2013)

Loading...


Caffeine and atrial fibrillation: friends or foes? Bhave PD and Hoffmayer K Heart 99(19), 1377-8, (2013)

Loading...


The toxicity of energy drinks: myth or reality? Hoyte C Clin. Toxicol. (Phila.) 51(8), 729-30, (2013)

Loading...


Protective effects of subchronic caffeine administration on cisplatin induced urogenital toxicity in male mice. Nasri H Indian J. Exp. Biol. 51(5), 406, (2013)

Loading...


Biomedicine. Human stem cells from cloning, finally. Vogel G Science 340(6134), 795, (2013)

Loading...


Merck 14,1636

Beil. 26,461 / Beil. 26,IV,2338

Aldrich MSDS 1, 343:A / Corp MSDS 1 (1), 664:C / FT-IR 1 (2), 710:B / FT-IR 2 (3), 3668:B / IR-Spectra (2), 1120:B / IR-Spectra (3), 1287:D / NMR-Reference 2 (2), 586:A / RegBook 1 (2), 2467:A / Sax 6, 615 / Sigma FT-IR 1 (1), 581:A / Structure Index 1, 390:E:3

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?