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C1778 Sigma-Aldrich

Caffeine

Sigma Reference Standard, vial of 250 mg

Synonym: 1,3,7-Trimethylxanthine

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Properties

Related Categories Alkaloid, Cell Biology, Nutrition Research, Phytochemicals by Chemical Classification
grade   Sigma Reference Standard
InChI Key   RYYVLZVUVIJVGH-UHFFFAOYSA-N
form   crystalline
  powder
packaging   vial of 250 mg
mp   234-236.5 °C(lit.)
solubility   H2O: soluble18.7 g/L at 16 °C
Gene Information   human ... ADORA1(134), ADORA2B(136), ADORA3(140), PDE4B(5142)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369)

Description

Packaging

1 vial in poly bottle

5 vials in poly bottle

Supplied in amber screw-cap vials

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C1778.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




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Safety & Documentation
Protocols & Articles
Peer-Reviewed Papers
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