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D4784 Sigma-Aldrich

4,5-Methylenedioxy-1,2-phenylenediamine dihydrochloride

Fluorogenic reagent

Synonym: 1,2-Diamino-4,5-methylenedioxybenzene dihydrochloride, 1,3-Benzodioxole-5,6-diamine dihydrochloride, 5,6-Diamino-1,3-benzodioxole dihydrochloride, MDB

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Derivatization agents, Hematology and Histology, Luminescent Compounds/Detection,
InChI Key   YXEJRYIEFFUUID-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
solubility   H2O: 50 mg/mL
storage temp.   −20°C

Description

Application

Fluorogenic reagent for α-ketoacids.

4,5-Methylenedioxy-1,2-phenylenediamine dihydrochloride has been used for the derivatization of sialic acids to analyse them by capillary liquid-chromatography-electrospray ionization/tandem mass spectrometry (CapLC-ESI-MS/MS).

Packaging

10, 50 mg in glass insert

100 mg in poly bottle

General description

4,5-Methylenedioxy-1,2-phenylenediamine dihydrochloride is a fluorescence tag for α keto acids. It is also required for the derivatization of sialic acids in presence of dilute sulfuric acid. The method allows determination of sialic acids.

Price and Availability


Tissue Diagnostics

All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Improving the Chromatographic Separation of DMB-Labeled Sialic Acids for the Comparison of Biosimilars to Reference Materials

Sialic acids are N- or O-substituted derivatives of neuraminic acid. They are important because they affect bioavailability, function, stability, and metabolism of glycoproteins. Two forms of sialic ...
Xiaoning Lu, Isil Yasa, Ben Cutak, Kevin Ray, David S. Bell
Reporter US Volume 33.2
Keywords: High performance liquid chromatography, Metabolism, Separation, Solvents

Peer-Reviewed Papers
15

References

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