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D7008 Sigma-Aldrich

Dihydroethidium

≥95%

Synonym: 2,7-Diamino-10-ethyl-9-phenyl-9,10-dihydrophenanthridine, 3,8-Diamino-5,6-dihydro-5-ethyl-6-phenylphenanthridine, Hydroethidine

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, D,
InChI Key   XYJODUBPWNZLML-UHFFFAOYSA-N
assay   ≥95%
form   powder
solubility   chloroform: soluble20 mg/mL
fluorescence   λex 370 nm; λem 420 nm (for cytoplasm of living cells)
  λex 535 nm; λem 610 nm (for chromatin of living cells)
storage temp.   −20°C

Description

Application

Dihydroethidium has been used as a superoxide probe in bovine pulmonary artery endothelial cell (BPAEC). It has been used to check the in situ generation of ROS (reactive oxygen species).

Redox indicator. Blue fluorescence until oxidized to ethidium.

Linkage

B-ring reduced analog of ethidium

Packaging

10 mg in poly bottle

Packaged under Argon.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Mitochondrial Stress and ROS

Oxidative stress is implicated in the pathogenesis of lipotoxicity in both animal and human studies. Chronic oxidative stress is linked to insulin resistance in multiple tissues. Oxidative stress is ...
BioFiles 2011, 6.4, 22.
Keywords: Anti-inflammatory agents, Apoptosis, Cancer, Cell signaling, Cellular processes, Gene expression, Indicators, Metabolism, Oxidations, Respiratory

Peer-Reviewed Papers
15

References

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