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E1271 Sigma-Aldrich

N-Ethylmaleimide

BioXtra, ≥98% (HPLC)

Synonym: NEM

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Properties

Related Categories Apoptosis Inhibitors, Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, Core Bioreagents,
InChI Key   HDFGOPSGAURCEO-UHFFFAOYSA-N
product line   BioXtra
assay   ≥98% (HPLC)
impurities   ≤0.001% Phosphorus (P)
  ≤0.1% Insoluble matter
ign. residue   ≤0.1%
bp   210 °C(lit.)
mp   43-46 °C(lit.)
solubility   95% ethanol: soluble50 mg/mL, clear to slightly hazy (colorless to faint yellow)
anion traces   chloride (Cl-): ≤0.05%
  sulfate (SO42-): ≤0.05%
cation traces   Al: ≤0.0005%
  Ca: ≤0.0005%
  Cu: ≤0.0005%
  Fe: ≤0.0005%
  K: ≤0.005%
  Mg: ≤0.0005%
  Na: ≤0.005%
  Pb: ≤0.001%
  Zn: ≤0.0005%
storage temp.   2-8°C
Gene Information   human ... SLC6A3(6531), SLC6A4(6532)

Description

Application

Reagent for the covalent modification of cysteine residues in proteins.

Biochem/physiol Actions

Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.

Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.

Packaging

1, 5 g in glass bottle

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




Flow Cytometry Instruments
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2928 8(6.1) / PGII
WGK Germany 
3
RTECS 
UX9625000
Flash Point(F) 
163.4 °F
Flash Point(C) 
73 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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