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E1769 Sigma-Aldrich

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

BioXtra

Synonym: N-Ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride, EDAC, EDC hydrochloride, EDC, WSC hydrochloride

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Properties

Related Categories Crosslinking, Heterobifunctional Cross-Linking Reagents, Molecular Biology, Protein Modification, Protein Structural Analysis,
InChI Key   FPQQSJJWHUJYPU-UHFFFAOYSA-N
product line   BioXtra
impurities   ≤0.005% Phosphorus (P)
  ≤0.1% Insoluble matter
ign. residue   ≤0.1%
mp   110-115 °C(lit.)
solubility   H2O: soluble0.5 M, clear, colorless
anion traces   sulfate (SO42-): ≤0.05%
cation traces   Al: ≤0.0005%
  Ca: ≤0.0005%
  Cu: ≤0.0005%
  Fe: ≤0.0005%
  K: ≤0.005%
  Mg: ≤0.0005%
  NH4+: ≤0.05%
  Na: ≤0.005%
  Pb: ≤0.001%
  Zn: ≤0.0005%
storage temp.   −20°C

Description

Packaging

1, 5, 10, 25 g in poly bottle

Biochem/physiol Actions

Water soluble condensing reagent. EDAC is generally utilized as a carboxyl activating agent for amide bonding with primary amines. In addition, it will react with phosphate groups. EDAC has been used in peptide synthesis; crosslinking proteins to nucleic acids; and preparation of immunoconjugates as examples. Typically, EDAC is utilized in the pH range 4.0-6.0 without buffers. In particular, amine and carboxylate buffers should be avoided.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
FF2200000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Poly(N-isopropylacrylamide)-based Smart Surfaces for Cell Sheet Tissue Engineering

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.1 Nonetheless, major challenges still need ...
Masamichi NakayamaTeruo Okano and Françoise M. Winnik
Material Matters 2010, 5.3, 56.
Keywords: Adhesion, Applications, Biomaterials, Cell culture, Clinical, Dehydration reaction, Growth factors, Hydration reaction, Immobilization, Inflammation, Ligands, Magnetic resonance spectroscopy, Material Matters, Polymerization reactions, Radical polymerization, Rearrangements, Reversible addition-fragmentation chain transfer polymerizations, Solvents

Protocols

EDC-mediated couplings of Polyester-16-hydroxyl-1-carboxyl bis-MPA dendron

This monodisperse compound has multiple surface hydroxyl groups and a single carboxylic acid focal point function. The carboxylic acid function is well suited for EDC-mediated coupling to amine-conta...
Keywords: Antibiotics, Biochemistry, Solvents

EDC-mediated couplings of Polyester-32-hydroxyl-1-carboxyl bis-MPA dendron

This monodisperse compound has multiple surface hydroxyl groups and a single carboxylic acid focal point function. The carboxylic acid function is well suited for EDC-mediated coupling to amine-conta...
Keywords: Antibiotics, Biochemistry, Solvents

EDC-mediated couplings of Polyester-8-hydroxyl-1-carboxyl bis-MPA dendron

Theoretical MW: 830.82 g/mol Average Molecular Formula: C35H58O22 Number of hydroxyl groups: 8 Number of carboxylic acid groups: 1
Keywords: Antibiotics, Biochemistry, Solvents

Peer-Reviewed Papers
15

References

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