N-Ethylmaleimide crystalline, ≥98% (HPLC)

Properties

Related Categories	A to C, Apoptosis Enzymes, Apoptosis Inhibitors, Apoptosis and Cell Cycle, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Broad Spectrum Inhibitors of Proteolytic Enzyme Classes, Bromelain, Calpain, Calpain II, Calpain II Inhibitors, Carnitine acetyltransferase, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Core Bioreagents, Cysteine Protease Inhibitors, E, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Ficin, General Inhibitors, Inhibitors, Protease Inhibitor Specificity Index, Protease Inhibitors, Proteasome, Calpain and Lysosomal Proteases, Proteasomes, Protein Modification, Protein Structural Analysis, Proteomics, Reagents for cysteine modification, Research Essentials, Specific Amino Acid Modification More...
Quality Level	PREMIUM
assay	≥98% (HPLC)
form	crystalline
bp	210 °C(lit.)
mp	43-46 °C(lit.)
storage temp.	2-8°C
Gene Information	human ... KCNQ2(3785), KCNQ4(9132), KCNQ5(56479), SLC6A3(6531), SLC6A4(6532)

Description

Application

Reagent for the covalent modification of cysteine residues in proteins.

Biochem/physiol Actions

Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.

Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.

Preparation Note

NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water (>50 mg in 4 ml); however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH.

Price and Availability

Related Papers

Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag. Matthew W Woods et al Retrovirology 8, 95, (2011)

Documents

Certificate of Analysis

Certificate of Origin

Pressure-Temperature Nomograph

Safety Information

Symbol	GHS05, GHS06
Signal word	Danger
Hazard statements	H300-H311-H314-H317
Precautionary statements	P264-P280-P301 + P310-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes (Europe)	T+
Risk Statements (Europe)	21-28-34-43
Safety Statements (Europe)	26-28-36/37/39-45
RIDADR	UN 2928 6.1/PG 2
WGK Germany	3
RTECS	UX9625000
Flash Point(F)	163.4 °F
Flash Point(C)	73 °C

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Papers

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Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag. Matthew W Woods et al Retrovirology 8, 95, (2011)

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Actin microfilament aggregation induced by withaferin A is mediated by annexin II. Ryan R Falsey et al Nat. Chem. Biol. 2, 33-8, (2006)

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Structure-activity relationships in the binding of chemically derivatized CD4 to gp120 from human immunodeficiency virus. Hui Xie et al J. Med. Chem. 50, 4898-908, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. Nicolas Matuszak et al J. Med. Chem. 52, 7410-20, (2009)

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Inhibition of monoamine oxidase B by N-methyl-2-phenylmaleimides. Clarina I Manley-King et al Bioorg. Med. Chem. 17, 3104-10, (2009)

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Antifungal, cytotoxic and SAR studies of a series of N-alkyl, N-aryl and N-alkylphenyl-1,4-pyrrolediones and related compounds. M Sortino et al Bioorg. Med. Chem. 19, 2823-34, (2011)

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Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor. Ayami Matsushima et al Bioorg. Med. Chem. 19, 7597-602, (2011)

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Reactions with N-ethylmaleimide and p-mecuribenzoate. Riordan, J.F. and Vallee, B.L. Meth. Enzymol. 25, 449-456, (1972)

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Chemical modification of sulfhydryl groups in p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Involvement in catalysis and assignment in the sequence. W.J.H. Van Berkel et al. Eur. J. Biochem. 145, 245, (1984)

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Merck 14,3822

Beil. 21,V,10,6

Aldrich MSDS 1, 918:D / Corp MSDS 1 (1), 1631:C / FT-IR 1 (1), 797:D / FT-IR 2 (1), 1354:B / FT-NMR 1 (1), 1304:A / IR-Spectra (2), 419:G / IR-Spectra (3), 473:C / NMR-Reference 2 (1), 669:A / RegBook 1 (1), 935:B / Sax 6, 1726 / Sigma FT-IR 1 (2), 555:D / Structure Index 1, 145:B:6

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N-Ethylmaleimide

crystalline, ≥98% (HPLC)

Properties

Description

Application

Biochem/physiol Actions

Preparation Note

Price and Availability

Related Papers

Documents

Safety Information

Papers

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