|Related Categories||A to C, Apoptosis Enzymes, Apoptosis Inhibitors, Apoptosis and Cell Cycle, Application Index,|
|Gene Information||human ... KCNQ2(3785), KCNQ4(9132), KCNQ5(56479), SLC6A3(6531), SLC6A4(6532)|
Reagent for the covalent modification of cysteine residues in proteins.
Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.
NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water (>50 mg in 4 ml); however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P264-P280-P301 + P310-P305 + P351 + P338-P310|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||21-28-34-43|
|Safety Statements (Europe)||26-28-36/37/39-45|
|RIDADR||UN 2928 6.1/PG 2|
|Flash Point(F)||163.4 °F|
|Flash Point(C)||73 °C|
Functional defects in the external and internal thin gates of the γ-aminobutyric acid (GABA) transporter GAT-1 can compensate each other. Ben-Yona A and Kanner BI J. Biol. Chem. 288(7), 4549-56, (2013)
Redox changes accompanying storage protein mobilization in moist chilled and warm incubated walnut kernels prior to germination. Shahmoradi Z, Tamaskani F, Sadeghipour HR, et al. J. Plant Physiol. 170(1), 6-17, (2013)
Functional consequences of sulfhydryl modification of the γ-aminobutyric acid transporter 1 at a single solvent-exposed cysteine residue. Omoto JJ, Maestas MJ, Rahnama-Vaghef A, et al. J. Membr. Biol. 245(12), 841-57, (2012)
Putative depolarisation-induced retrograde signalling accelerates the repeated hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus via group I metabotropic glutamate receptors. Nuritova F and Frenguelli BG Neuroscience 222, 159-72, (2012)
Granulomorphometry: a suitable tool for identifying hydrophobic and disulfide bonds in β-lactoglobulin aggregates. Application to the study of β-lactoglobulin aggregation mechanism between 70 and 95°C. Petit J, Herbig AL, Moreau A, et al. J. Dairy Sci. 95(8), 4188-202, (2012)
Individual interferon regulatory factor-3 thiol residues are not critical for its activation following virus infection. Zucchini N, Williams V, and Grandvaux N J. Interferon Cytokine Res. 32(9), 393-400, (2012)
Effect of moisture, lipids, and select amino acid blocking agents on the formation and stability of metastable radicals in powdered soy proteins. Boatright WL, Lei Q, and Jahan MS J. Food Sci. 77(6), C620-6, (2012)
Gastroprotection of suaveolol, isolated from Hyptis suaveolens, against ethanol-induced gastric lesions in Wistar rats: role of prostaglandins, nitric oxide and sulfhydryls. Vera-Arzave C, Antonio LC, Arrieta J, et al. Molecules 17(8), 8917-27, (2012)
Chemical modification of sulfhydryl groups in p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Involvement in catalysis and assignment in the sequence. W.J.H. Van Berkel et al. Eur. J. Biochem. 145, 245, (1984)
Aldrich MSDS 1, 918:D / Corp MSDS 1 (1), 1631:C / FT-IR 1 (1), 797:D / FT-IR 2 (1), 1354:B / FT-NMR 1 (1), 1304:A / IR-Spectra (2), 419:G / IR-Spectra (3), 473:C / NMR-Reference 2 (1), 669:A / RegBook 1 (1), 935:B / Sax 6, 1726 / Sigma FT-IR 1 (2), 555:D / Structure Index 1, 145:B:6
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