Synonym: Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na2, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na2
|Related Categories||Analytical Reagents, Analytical/Chromatography, Biochemicals and Reagents, Broad Spectrum Inhibitors of Proteolytic Enzyme Classes, Calcium Chelators,|
|mp||248 °C (dec.)(lit.)|
|solubility||H2O: soluble, clear, colorless|
Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.
1 kg in poly bottle
2.5, 5 kg in poly drum
50, 100, 250, 500 g in poly bottle
Zinc-dependent metalloproteinases, as well as other proteases that are stabilized by calcium, can be effectively inhibited by chelation of divalent metal ions with EDTA. Other chelators such as EGTA, specific for calcium, and 1,10-phenanthroline, highly specific for zinc, can be used to target these two different types of proteases.
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Certificate of Origin
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Keywords: AGE, Alzheimer Disease, Angiogenesis, Anti-inflammatory agents, Cancer, Cardiovascular, Cell proliferation, Degradations, Diabetes, Digestions, Gene expression, Hormones, Inflammation, Metabolism, Neurotransmitters, Normal-phase chromatography, Obesity, Respiratory, Schizophrenia, Sequencing
1. OBJECTIVE To standardize a procedure for the determination of the enzymatic assay of choloylglycine hydrolase.
Keywords: Enzyme activity
1. OBJECTIVE To standardize a procedure for the enzymatic determination of superoxide dismutase.
Keywords: Catalysis, Reductions
Oxidative damage of rat liver mitochondria during exposure to t-butyl hydroperoxide. Role of Ca²⁺ ions in oxidative processes. Zavodnik IB, Dremza IK, Cheshchevik VT, et al. Life Sci. 92(23), 1110-7, (2013)
Zn(2+) rather than Ca(2+) or Mg(2+) used as a cofactor in non-muscular actin from the oyster to control protein polymerization. Yang X, Lv C, Zhang S, et al. Biochim. Biophys. Acta 1830(8), 4179-88, (2013)
The effect of amniotic membrane de-epithelialization method on its biological properties and ability to promote limbal epithelial cell culture. Zhang T, Yam GH, Riau AK, et al. Invest. Ophthalmol. Vis. Sci. 54(4), 3072-81, (2013)
Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. Lamas GA, Goertz C, Boineau R, et al. JAMA 309(12), 1241-50, (2013)
Novel lipoprotein density profiling in healthy dogs of various breeds, healthy Miniature Schnauzers, and Miniature Schnauzers with hyperlipidemia. Xenoulis PG, Cammarata PJ, Walzem RL, et al. BMC Vet. Res. 9, 47, (2013)
Enzymatic activity of a subtilisin homolog, Tk-SP, from Thermococcus kodakarensis in detergents and its ability to degrade the abnormal prion protein. Hirata A, Hori Y, Koga Y, et al. BMC Biotechnol. 13, 19, (2013)
Brand of dipotassium EDTA vacuum tube as a new source of pre-analytical variability in routine haematology testing. Lima-Oliveira G, Lippi G, Salvagno GL, et al. Br. J. Biomed. Sci. 70(1), 6-9, (2013)
Reclamation of copper-contaminated soil using EDTA or citric acid coupled with dissolved organic matter solution extracted from distillery sludge. Liu CC and Lin YC Environ. Pollut. 178, 97-101, (2013)
The regulation of apoptosis by the downstream regulatory element antagonist modulator/potassium channel interacting protein 3 (DREAM/KChIP3) through interactions with hexokinase I. Craig TA, Ramachandran PL, Bergen HR, et al. Biochem. Biophys. Res. Commun. 433(4), 508-12, (2013)
Iron bioavailability from a lipid-based complementary food fortificant mixed with millet porridge can be optimized by adding phytase and ascorbic acid but not by using a mixture of ferrous sulfate and sodium iron EDTA. Cercamondi CI, Egli IM, Mitchikpe E, et al. J. Nutr. 143(8), 1233-9, (2013)
Effect of three different contamination removal methods on bond strength of a self-etching adhesive to dentin contaminated with an aluminum chloride hemostatic agent. Ajami AA, Kahnamoii MA, Kimyai S, et al. J. Contemp. Dent. Pract. 14(1), 26-33, (2013)
Facile preparation of glutathione-stabilized gold nanoclusters for selective determination of chromium (III) and chromium (VI) in environmental water samples. Zhang H, Liu Q, Wang T, et al. Anal. Chim. Acta 770, 140-6, (2013)
Corp MSDS 1 (1), 1606:D / FT-IR 2 (1), 902:B / FT-IR 1 (1), 567:B / IR-Spectra (2), 303:G / IR-Spectra (3), 340:D / RegBook 1 (1), 647:I / Sigma FT-IR 1 (2), 549:B / Structure Index 1, 94:A:8
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