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F7878 Sigma-Aldrich

Folinic acid calcium salt hydrate

analytical standard

Synonym: 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt

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Properties

Related Categories Additional Drugs, Analytical Standards, Analytical/Chromatography, Biochemicals and Reagents, Coenzymes and Cofactors,
grade   analytical standard
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
format   neat

Description

Application

Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Same product — same quality — now Sigma-Aldrich brand

Packaging

1 g in glass bottle

100, 500 mg in glass bottle

Price and Availability


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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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