|Related Categories||Allium cepa (Onion), Allium sativum (Garlic), Amino Acid, Amino Acid Library, Amino Acids,|
|mp||192-195 °C (dec.)(lit.)|
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May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.
Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.
1, 5, 10, 25, 50, 100, 250, 500 g in poly bottle
300 mg in poly bottle
10 mg in autosample vial
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Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
BioFiles 2007, 2.2, 2.
Keywords: Adhesion, Anti-inflammatory agents, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins
Oxidative stress is implicated in the pathogenesis of lipotoxicity in both animal and human studies. Chronic oxidative stress is linked to insulin resistance in multiple tissues. Oxidative stress is ...
BioFiles 2011, 6.4, 22.
Keywords: Anti-inflammatory agents, Apoptosis, Cancer, Cell signaling, Cellular processes, Gene expression, Indicators, Metabolism, Oxidations, Respiratory
Coordinated transcriptional regulation of two key genes in the lignin branch pathway--CAD and CCR--is mediated through MYB- binding sites. Rahantamalala A, Rech P, Martinez Y, et al. BMC Plant Biol. 10, 130, (2010)
Investigation of the effects of Chlorella vulgaris supplementation on the modulation of oxidative stress in apparently healthy smokers. Panahi Y, Mostafazadeh B, Abrishami A, et al. Clin. Lab. 59(5-6), 579-87, (2013)
Green tea catechins based functional drink (Green cool) improves the antioxidant status of SD rats fed on high cholesterol and sucrose diets. Ahmad RS, Butt MS, Huma N, et al. Pak. J. Pharm. Sci. 26(4), 721-6, (2013)
Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to D-lactate. Masterjohn C, Mah E, Park Y, et al. Exp. Biol. Med. (Maywood.) 238(4), 360-9, (2013)
The administration of N-acetylcysteine reduces oxidative stress and regulates glutathione metabolism in the blood cells of workers exposed to lead. Kasperczyk S, Dobrakowski M, Kasperczyk A, et al. Clin. Toxicol. (Phila.) 51(6), 480-6, (2013)
Antioxidant responses and renal crystal formation in rainbow trout treated with melamine administered individually or in combination with cyanuric acid. Pacini N, Prearo M, Abete MC, et al. J. Toxicol. Environ. Health A 76(8), 491-508, (2013)
Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after intense eccentric exercise. Michailidis Y, Karagounis LG, Terzis G, et al. Am. J. Clin. Nutr. 98(1), 233-45, (2013)
MT-α-glucan from the fruit body of the maitake medicinal mushroom Grifola frondosa (higher Basidiomyetes) shows protective effects for hypoglycemic pancreatic β-cells. Lei H, Zhang M, Wang Q, et al. Int. J. Med. Mushrooms 15(4), 373-81, (2013)
Amelioration of cognitive, motor and endogenous defense functions with silymarin, piracetam and protocatechuic acid in the cerebral global ischemic rat model. Muley MM, Thakare VN, Patil RR, et al. Life Sci. 93(1), 51-7, (2013)
Protective effect of AVS073, a polyherbal formula, against UVA-induced melanogenesis through a redox mechanism involving glutathione-related antioxidant defense. Panich U, Pluemsamran T, Tangsupa-a-nan V, et al. BMC Complement Altern. Med. 13, 159, (2013)
Disturbance of redox homeostasis by ornithine and homocitrulline in rat cerebellum: a possible mechanism of cerebellar dysfunction in HHH syndrome. Zanatta A, Viegas CM, Tonin AM, et al. Life Sci. 93(4), 161-8, (2013)
Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism. Tavazzi B, Lazzarino G, Leone P, et al. Clin. Biochem. 38(11), 997-1008, (2005)
Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children. Bayir H, Kagan VE, Tyurina YY, et al. Pediatr. Res. 51(5), 571-8, (2002)
Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: evidence for a protective role of acetylcarnitine. Calabrese V, Scapagnini G, Ravagna A, et al. Neurochem. Res. 28(9), 1321-8, (2003)
Contribution of canalicular glutathione efflux to bile formation. From cholestasis associated alterations to pharmacological intervention to modify bile flow. Grattagliano I, Portincasa P, Palmieri VO, et al. Curr. Drug Targets. Immune. Endocr. Metabol. Disord. 5(2), 153-61, (2005)
Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer. Kaynar H, Meral M, Turhan H, et al. Cancer Lett. 227(2), 133-9, (2005)
OATP8/1B3-mediated cotransport of bile acids and glutathione: an export pathway for organic anions from hepatocytes? Briz O, Romero MR, Martinez-Becerra P, et al. J. Biol. Chem. 281(41), 30326-35, (2006)
A comparative study of nitric oxide, glutathione, and glutathione peroxidase activities in cerebrospinal fluid from children with convulsive diseases/children with aseptic meningitis. Kawakami Y, Monobe M, Kuwabara K, et al. Brain Dev. 28(4), 243-6, (2006)
Analysis of glutathione and glutathione disulfide in human saliva using hydrophilic interaction chromatography with mass spectrometry. Iwasaki Y, Hoshi M, Ito R, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 839(1-2), 74-9, (2006)
Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites. Zamek-Gliszczynski MJ, Hoffmaster KA, Nezasa K, et al. Eur. J. Pharm. Sci. 27(5), 447-86, (2006)
The effect of L-cysteine and glutathione on inhibition of Na+, K+-ATPase activity by aspartame metabolites in human erythrocyte membrane. Schulpis KH, Papassotiriou I, Parthimos T, et al. Eur. J. Clin. Nutr. 60(5), 593-7, (2006)
Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti: a case study in Martinique Island (French West Indies). Sébastien Marcombe et al BMC Genomics 10, 494, (2009)
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)
Antioxidant capacity of human blood plasma and human urine: simultaneous evaluation of the ORAC index and ascorbic acid concentration employing pyrogallol red as probe. P Torres et al Bioorg. Med. Chem. 16, 9171-5, (2008)
Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox. Mario Faúndez et al Antimicrob. Agents Chemother. 52, 1837-9, (2008)
Role of the Mycobacterium tuberculosis P55 efflux pump in intrinsic drug resistance, oxidative stress responses, and growth. Santiago Ramón-García et al Antimicrob. Agents Chemother. 53, 3675-82, (2009)
FT-IR 1 (1), 787:D / FT-IR 2 (1), 1334:C / FT-NMR 1 (1), 1283:B / IR-Spectra (2), 414:G / IR-Spectra (3), 467:F / RegBook 1 (1), 919:L / Sax 6, 1478 / Sigma FT-IR 1 (1), 359:B / Structure Index 1, 143:B:1
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|G3664||Glutathione Reductase from baker's yeast (S. cerevisiae), ammonium sulfate suspension, 100-300 units/mg protein (biuret)|
|L4530||Latex beads, carboxylate-modified polystyrene, fluorescent yellow-green, aqueous suspension, 2.0 μm mean particle size|
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