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H4784 Sigma-Aldrich

Heparin sodium salt from porcine intestinal mucosa

≥180 USP units/mg

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Properties

Related Categories Biochemicals and Reagents, Carbohydrates, Carbohydrates A to Z, Carbohydrates H-L, Core Bioreagents,
solubility   H2O: soluble50 mg/mL, clear, colorless to faintly yellow
cation traces   Ca: ≤20 ppm
storage temp.   2-8°C

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Packaging

1 g in poly bottle

250 mg in poly bottle

Quality

Low calcium content

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
MI0850000

Documents

Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

How does the storage temperature relate to shipping conditions?
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. http://www.sigmaaldrich.com/etc/medialib/docs/Sigma-Aldrich/General_Information/shippingandlong-termstoragev3.Par.0001.File.tmp/shippingandlong-termstoragev3.pdf
What are the units used for Heparin sodium salt?
Units are USP (United States Pharmacopeia units), which is defined by the USP Heparin Sodium Reference Standard.  As of October 2009, the USP aligned the USP units with the International Units. Please see the following link that describes the change in the USP monograph: http://www.usp.org/usp-nf/hot-topics/heparin/official-stage-2-monographs
What is the molecular weight of Heparin sodium salt?
Heparin is a mixture of polyanion chains having molecular weights ranging from 6,000 to 30,000 Daltons, with most chains in the range of 17,000 to 19,000 Daltons.
How much Heparin sodium salt, is used to prevent coagulation?
We suggest using 20 to 50 units per mL of blood.  
What is the best way to sterilize Heparin sodium salt?
Although solutions may be autoclaved at 121 °C for 5 to 10 minutes, we generally recommend sterile filtration. This is because prolonged autoclaving may have an effect on its activity.  
What concentration of Heparin sodium salt, can I use to inhibit RNAse activity?
What concentration can I use to inhibit RNase activity?" Change answer to: "Heparin has been used at concentrations ranging from 100 to 500 µg/mL. This has been reported in the J. Biol. Chem., 248, 2095 (1973).
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
What is the pH of a 1% solution of Product H4784, Heparin sodium salt?
The pH of 1% solution of heparin sodium salt is typically in the range of 6.0 to 7.5.
What concentration of Product H4784, Heparin sodium salt, is used in cell culture for the cultivation of human epidermal melanocytes in absence of phorbol esters?
Heparin is used at a concentration of 1 ng/mL, according to Picot, J., Human Cell Culture: Methods in Molecular Medicine, 2nd ed., (Humana Press Inc., 2005) pp. 13-28.
Show more questions
Protocols & Articles

Articles

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units. The disaccharide units that are the basis of all glycosaminoglycans (except keratan) are a combination...
Vicki Caligur
BioFiles 2008, 3.10, 4.
Keywords: Adhesion, Aminations, Angiogenesis, Anticoagulants, Apoptosis, Atomic absorption spectroscopy, Cancer, Cell biology, Cell proliferation, Cell signaling, Cellular processes, Central Nervous System, Chromatography, Coagulation, Degradations, Enzyme-linked immunosorbent assay, Epimerizations, Gene expression, Genetic, Genomics, Growth factors, Help, High performance liquid chromatography, Inflammation, Ion-exchange chromatography, Ligands, Mass spectrometry, Methods, Microarray Analysis, Morphogenesis, Nuclear magnetic resonance spectroscopy, Phosphorylations, Polymerase chain reaction, Polymerization reactions, Proteomics, Reductive aminations, Sequences, Spectroscopy, Sulfations, Transcription, Type, transformation

Peer-Reviewed Papers
15

References

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