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H7753 Sigma-Aldrich

Hexestrol

analytical standard

Synonym: 4,4′-(1,2-Diethylethylene)diphenol, meso-3,4-Bis(4-hydroxyphenyl)hexane, Dihydrodiethylstilbestrol

  • CAS Number 84-16-2

  • Empirical Formula (Hill Notation) C18H22O2

  • Molecular Weight 270.37

  •  Beilstein Registry Number 3209460

  •  EC Number 201-518-1

  •  MDL number MFCD00068996

  •  PubChem Substance ID 329815246

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Properties

Related Categories Additional Drugs, Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography,
grade   analytical standard
InChI Key   PBBGSZCBWVPOOL-HDICACEKSA-N
assay   ≥98%
form   neat
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
format   neat
Gene Information   human ... ESR1(2099)
rat ... Esr1(24890)

Description

Biochem/physiol Actions

The carcinogen hexestrol is a nonsteroidal synthetic estrogen. Metabolic activation of hexestrol to its quinone, which reacts with DNA to form analogous depurinating adducts, may be a primary critical event leading to oncogenic mutations and cancer initiation.

Linkage

Reduced analogue of diethylstilbestrol.

Packaging

1, 5 g in poly bottle

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
SL0560850

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Degradations, Eliminations, Environmental, Enzymology, Gene expression, Genetic, Infrared spectroscopy, Metabolites, Methylations, Mutagens, Oncology, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription, transformation

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

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