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I5500 Sigma-Aldrich

Insulin from bovine pancreas

≥27 USP units/mg (HPLC), powder



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Biochem/physiol Actions

Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

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European Pharmacopoeia (EP) Reference Standard

powder, BioReagent, suitable for cell culture

Hybri-Max, powder, suitable for hybridoma

meets USP testing specifications

γ-irradiated, BioXtra, suitable for cell culture, potency: ≥25 units/mg (USP units), lyophilized powder

Safety & Documentation

Safety Information

WGK Germany 

Protocols & Articles


Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers


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A Novel Purification Method For CNS Projection Neurons Leads To The Identification Of Brain Vascular Cells As A Source Of Trophic Support For Corticospinal Motor Neurons. Dugas, J.C., et al. J. Neurosci. 28, 8294-305, (2008)


Differentiating human multipotent mesenchymal stromal cells regulate microRNAs: prediction of microRNA regulation by PDGF during osteogenesis. Goff, LA Exp. Hematol. 36(10), 1354-1369, (2008)


Species variation in the amino acid sequence of insulin. Smith, L.F. Am. J. Med. 40, 662-666, (1966)


Insulin-sensitive glucose transport. Kono, T. Vitam. Horm. 7, 103-154, (1988)


Zebrafish primordial germ cell cultures derived from vasa::RFP transgenic embryos. Lianchun Fan et al Stem Cells Dev. 17, 585-97, (2008)


Inhibition of lung tumor colonization and cell migration with the disintegrin crotatroxin 2 isolated from the venom of Crotalus atrox. Galán, JA Toxicon 51(7), 1186-96, (2008)


Prostate stem cell antigen DNA vaccination breaks tolerance to self-antigen and inhibits prostate cancer growth. Ahmad S Mol. Ther. 17(6), 1101-8, (2009)


Identification of a second lipopolysaccharide in Porphyromonas gingivalis W50. Rangarajan M J. Bacteriol. 190(8), 2920-32, (2008)


Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus. Ian S. Zagon et al Arch. Ophthal. 127, 1468-73, (2010)


Analysis of conjunctival fibroblasts from a proband with Schnyder corneal dystrophy. Jodhbir S. Mehta et al Mol. Vis. 14, 1277-81, (2008)


Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells. Naito A Cancer Sci. 99(8), 1584-8, (2008)


Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Angel Gu et al Exp. Cell Res. 315, 1668-82, (2009)


LIP expression is regulated by IGF-1R signaling and participates in suppression of anoikis. Huili Li et al Mol. Cancer 10, 100, (2011)


Isothiocyanates repress estrogen receptor alpha expression in breast cancer cells. Kang, L Oncol. Rep. 21(1), 185-92, (2009)


Merck 14,4980

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I1882 Insulin from bovine pancreas, γ-irradiated, BioXtra, suitable for cell culture, potency: ≥25 units/mg (USP units), lyophilized powder
I9278 Insulin solution human, Chemically defined, recombinant from Saccharomyces cerevisiae, sterile-filtered, BioXtra, suitable for cell culture

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