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I5500 Sigma-Aldrich

Insulin from bovine pancreas

≥27 USP units/mg (HPLC), powder

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Description

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Biochem/physiol Actions

Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

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10 mg/mL insulin in 25  mM HEPES, pH 8.2, BioReagent, sterile-filtered, suitable for cell culture

Safety & Documentation

Safety Information

WGK Germany 
3

Protocols & Articles

Articles

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers

References

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Species variation in the amino acid sequence of insulin. Smith, L.F. Am. J. Med. 40, 662-666, (1966)

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Insulin-sensitive glucose transport. Kono, T. Vitam. Horm. 7, 103-154, (1988)

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Prostate stem cell antigen DNA vaccination breaks tolerance to self-antigen and inhibits prostate cancer growth. Ahmad S Mol. Ther. 17(6), 1101-8, (2009)

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A Novel Purification Method For CNS Projection Neurons Leads To The Identification Of Brain Vascular Cells As A Source Of Trophic Support For Corticospinal Motor Neurons. Dugas, J.C., et al. J. Neurosci. 28, 8294-305, (2008)

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Zebrafish primordial germ cell cultures derived from vasa::RFP transgenic embryos. Lianchun Fan et al Stem Cells Dev. 17, 585-97, (2008)

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Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus. Ian S. Zagon et al Arch. Ophthal. 127, 1468-73, (2010)

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Analysis of conjunctival fibroblasts from a proband with Schnyder corneal dystrophy. Jodhbir S. Mehta et al Mol. Vis. 14, 1277-81, (2008)

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Differentiating human multipotent mesenchymal stromal cells regulate microRNAs: prediction of microRNA regulation by PDGF during osteogenesis. Goff, LA Exp. Hematol. 36(10), 1354-1369, (2008)

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Identification of a second lipopolysaccharide in Porphyromonas gingivalis W50. Rangarajan M J. Bacteriol. 190(8), 2920-32, (2008)

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Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells. Naito A Cancer Sci. 99(8), 1584-8, (2008)

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Inhibition of lung tumor colonization and cell migration with the disintegrin crotatroxin 2 isolated from the venom of Crotalus atrox. Galán, JA Toxicon 51(7), 1186-96, (2008)

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LIP expression is regulated by IGF-1R signaling and participates in suppression of anoikis. Huili Li et al Mol. Cancer 10, 100, (2011)

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Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Angel Gu et al Exp. Cell Res. 315, 1668-82, (2009)

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Isothiocyanates repress estrogen receptor alpha expression in breast cancer cells. Kang, L Oncol. Rep. 21(1), 185-92, (2009)

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Merck 14,4980

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