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M3501 Sigma-Aldrich

8-Methoxypsoralen

analytical standard

Synonym: 8-MOP, 9-Methoxyfuro[3,2-g][1]benzopyran-7-one, Ammoidin, Methoxsalen, Xanthotoxin

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Phenylpropanes, Phytochemical Standards
grade   analytical standard
InChI Key   QXKHYNVANLEOEG-UHFFFAOYSA-N
form   crystals
  fibers
  neat
  powder
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
color   white to yellow
mp   148-150 °C(lit.)
solubility   H2O: slightly soluble
  acetic acid: soluble
format   neat
Gene Information   rat ... Maoa(29253)

Description

Biochem/physiol Actions

8-methoxypsoralen (8-MOP) plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. 8-MOP is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca2+].

Caution

Protect from light.

Other Notes

Same product — same quality — now Sigma-Aldrich brand

Packaging

1, 5 g in glass bottle

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
LV1400000
Protocols & Articles

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Peer-Reviewed Papers
15

References

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