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M3501 Sigma-Aldrich

8-Methoxypsoralen

analytical standard

Synonym: 8-MOP, 9-Methoxyfuro[3,2-g][1]benzopyran-7-one, Ammoidin, Methoxsalen, Xanthotoxin

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Phenylpropanes, Phytochemical Standards
grade   analytical standard
InChI Key   QXKHYNVANLEOEG-UHFFFAOYSA-N
form   crystals
  fibers
  neat
  powder
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
color   white to yellow
mp   148-150 °C(lit.)
solubility   H2O: slightly soluble
  acetic acid: soluble
format   neat
Gene Information   rat ... Maoa(29253)

Description

Biochem/physiol Actions

8-methoxypsoralen (8-MOP) plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. 8-MOP is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca2+].

Caution

Protect from light.

Packaging

1, 5 g in glass bottle

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
LV1400000
Protocols & Articles

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Peer-Reviewed Papers
15

References

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