|Related Categories||Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application,|
Antibiotic with bactericidal action on E. coli.4,5 Binds to the lipid A portion of bacterial lipopolysaccharides.6 Induces pore formation in the membranes of cortex cells from excised sorghum roots.7
Mode of Action: Binds to and interferes with the permeability of the cytoplasmic membrane.
Antimicrobial spectrum: Gram-negative bacteria.
Polymyxin B sulfate has a bactericidal action against almost all Gram-negative bacilli except the Proteus group. Polymyxin B sulfate interacts with the lipid A portion of bacterial lipopolysaccharides, which alters cytoplasmic membrane permeability. It induces pore formation in the membranes of cortex cells from excised sorghum roots. It is used as an immobilized (substrate bound) agent for removal of endotoxins1.
Mixture of Polymyxin B1 and B2 sulfate.
Polymyxin B sulfate is a mixture of Polymyxin B1 and B2 sulfate. It is used clinically to treat infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa1. It is used to study multidrug-resistant pathogens2,3.
Certificate of Analysis
Certificate of Origin
7. Lerner, H.R., et al. Physiol. Plant. 57, 90, (1983)
Development of a selective enrichment broth supplemented with bacteriological charcoal and a high concentration of polymyxin B for the detection of Campylobacter jejuni and Campylobacter coli in chicken carcass rinses. Chon JW, Kim H, Yim JH, et al. Int. J. Food Microbiol. 162(3), 308-10, (2013)
The interaction of polysaccharide from Auricularia polytricha with quantum dots and the protection of plasmid DNA from damage. Wang W, Zhang G, and Zou J Appl. Biochem. Biotechnol. 169(8), 2263-72, (2013)
Intraventricular polymyxin B for the treatment of neonatal meningo-ventriculitis caused by multi-resistant Acinetobacter baumannii--case report and review of literature. Piparsania S, Rajput N, and Bhatambare G Turk. J. Pediatr. 54(5), 548-54, (2012)
Direct hemoperfusion with a polymyxin B column versus vasopressin for gram negative septic shock: a matched cohort study of the effect on survival. Sawa N, Ubara Y, Sumida K, et al. Clin. Nephrol. 79(6), 463-70, (2013)
The novel polymyxin derivative NAB739 is remarkably less cytotoxic than polymyxin B and colistin to human kidney proximal tubular cells. Vaara M and Vaara T Int. J. Antimicrob. Agents 41(3), 292-3, (2013)
Cost-effectiveness of perioperative selective decontamination of the digestive tract versus placebo in elective gastrointestinal surgery. Dijksman LM, Roos D, Gerhards MF, et al. Dig. Surg. 29(5), 384-90, (2012)
Use of a surfactant (polysorbate 80) to improve MIC susceptibility testing results for polymyxin B and colistin. Sader HS, Rhomberg PR, Flamm RK, et al. Diagn. Microbiol. Infect. Dis. 74(4), 412-4, (2012)
Optimizing hollow-fiber-based pharmacokinetic assay via chemical stability study to account for inaccurate simulated drug clearance of rifampicin. New LS, Lim TP, Oh JW, et al. Anal. Bioanal. Chem 405(4), 1407-15, (2013)
A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children. Williams L, Malhotra Y, Murante B, et al. J. Pediatr. 162(4), 857-61, (2013)
10'(Z),13'(E)-heptadecadienylhydroquinone inhibits swarming and virulence factors and increases polymyxin B susceptibility in Proteus mirabilis. Liu MC, Lin SB, Chien HF, et al. PLoS ONE 7(9), e45563, (2012)
[Case report; A case of acute respiratory failure following influenza virus infection successfully treated by direct hemoperfusion using a polymyxin B immobilized fiber column]. Arai D, Fukunaga K, Fujii K, et al. Nippon. Naika Gakkai Zasshi. 102(2), 429-32, (2013)
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