P6148 Sigma-Aldrich


reagent grade, crystalline

Synonym: Polyoxymethylene



Related Categories Apoptosis Reagents, Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, Core Bioreagents,
grade   reagent grade
vapor density   1.03 (vs air)
vapor pressure   <1.45 mmHg ( 25 °C)
form   crystalline
autoignition temp.   572 °F
expl. lim.   73 %
mp   120-170 °C(lit.)
density   0.88 g/mL at 25 °C(lit.)
storage temp.   2-8°C


Frequently Asked Questions

Frequently Asked Questions are available for this Product.


1 kg in poly bottle

5 kg in poly drum

500 g in poly bottle


Paraformaldehyde is recommended for use in the preparation of formalin fixatives for tissues or cells when the samples are to be used in florescence studies.
Paraformaldehyde has been used for fixing of cells and tissue sections during staining procedures.

General description

Paraformaldehyde is a cross-linking fixative. It is changed to formaldehyde by heating and by adding small amount of sodium hydroxide.

Price and Availability

Tissue Diagnostics

All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

Signal word 
UN 2213 4.1 / PGIII
WGK Germany 
Flash Point(F) 
158 °F
Flash Point(C) 
70 °C


Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

What is the difference between formaldehyde and paraformaldehyde?
Paraformaldehyde is the polymeric form of formaldehyde. Paraformaldehyde is a solid, and formaldehyde is a gas. Formaldehyde solutions consist of formaldehyde gas dissolved in a solvent of some kind.
What is the shelf life of Product P6148, Paraformaldehyde?
The shelf life has not been assigned but guarantee of quality is 1 year from the time of receipt for unopened bottles stored at 2-8 °C.  We expect the product to be of good quality for at least 2 years. Please also see our general statement on product shelf life:
How does Product P6148, Paraformaldehyde, compare to prilled paraformaldehyde, Product 441244?
Prilled has the appearance of small white beads.  Product P6148 is a powder, not prilled.  The answer can also be found by clicking on the following link:
How stable are Product P6148, Paraformaldehyde, solutions?
Buffered solutions of 2-4% can be stored protected from light for 2-3 weeks at 2-8°C.  This answer can also be found by clicking on the following link to the product information sheet:
How to prepare solutions of Product P6148, Paraformaldehyde?
Paraformaldehyde does not dissolve but rather can be depolymerized in solution. Depolymerized solutions can be prepared in water with heating to 55-60°C. If necessary, further addition of 1-2 drops of a sodium hydroxide solution may be required. Some protocols suggest that paraformaldehyde should be prepared in buffered solutions such as phosphate buffer or PBS at approximately pH 7.  For more details click on the following link.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option:
What is the difference between formaldehyde and paraformaldehyde?
Paraformaldehyde is the polymeric form of formaldehyde. It is a solid. Formaldehyde is a gas which when dissolved in water gives a formaldehyde solution. Commercially available formaldehyde solutions usually contain 10-15% methanol, which prevents the formaldehyde from forming the polymeric paraformaldehyde.
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
What are the differences between the Paraformaldheyde products and which is best suited for use as a fixative for Electron Microscopy?
Product 16005 is sold only in Europe and is not available to US customers. The primary differences among the various products is in the form for each product.  P6148 is listed as crystalline, 158127 is listed as powder, and 441244 is listed as prilled. The product information page for 441244 states the prilled form will go into solution more readily, but the prilled, crystalline, and powder forms are equivalent in terms on use. The prilled form is expected to slow down the rate of sublimation compared to the powder or the crystalline forms.   Any of the 3 products should be suitable for use as a fixative.  However, once prepared, paraformaldehyde solutions are unstable unless methanol is added as a stabilizer. Customer options vary from preparing solutions daily to storing solutions for 2 or 3 weeks. If used as a fixative for electron microscopy, we recommend preparing solutions fresh daily to avoid the risk of repeating tedious EM work due to deterioration of the fixative.  For less critical applications, it would be more acceptable to use solutions stored for longer periods of time.
Show more questions
Protocols & Articles
Peer-Reviewed Papers


Related Products

related product

Product #


Add to Cart

08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?