• USA Home
  • PHR1084 - Metformin hydrochloride

EMAIL THIS PAGE TO A FRIEND
PHR1084 Sigma-Aldrich

Metformin hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 1,1-Dimethylbiguanide hydrochloride, Metformin

Purchase

Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards,
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   OETHQSJEHLVLGH-UHFFFAOYSA-N
form   neat
mp   223-226 °C(lit.)
format   neat
pharmacopeia traceability   traceable to PhEur M0605000
  traceable to USP 1396309

Description

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Biochem/physiol Actions

Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3694 in the slot below. This is an example certificate only and may not be the lot that you receive.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
DU1800000
Protocols & Articles

Articles

LC/MS Analysis of Melamine and Metformin on Ascentis® Express HILIC

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Melamine and Metformin on Ascentis® Express HILIC
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?