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PHR1092 Sigma-Aldrich

Cyclosporine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Antibiotic S 7481F1, Cyclosporin A, Cyclosporine

  • CAS Number 59865-13-3

  • Empirical Formula (Hill Notation) C62H111N11O12

  • Molecular Weight 1202.61

  •  Beilstein Registry Number 3647785

  •  MDL number MFCD00274558

  •  PubChem Substance ID 329823114

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards,
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   PMATZTZNYRCHOR-CGLBZJNRSA-N
form   neat
format   neat
pharmacopeia traceability   traceable to PhEur C2163000
  traceable to USP 1158504

Description

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).

Biochem/physiol Actions

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA8977 in the slot below. This is an example certificate only and may not be the lot that you receive.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
GZ4120000
Protocols & Articles

Articles

LC/MS/MS Analysis of Immunosuppressant Drugs in Human Plasma on Ascentis® Express F5 after SPE Using HybridSPE®-Phospholipid

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Immunosuppressant Drugs in Human Plasma on Ascentis® Express F5 after SPE Using HybridSPE®-Phospholipid
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Sample preparations, Separation, Solid phase extractions, Solvents, Vitamins

LC/MS/MS Analysis of Immunosuppressant Drugs on apHera™ C18

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Immunosuppressant Drugs on apHera™ C18
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Solvents

Peer-Reviewed Papers
15

References

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