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PHR1095 Sigma-Aldrich

Caffeine Melting Point Standard

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: 1,3,7-Trimethylxanthine, Caffeine

  • CAS Number 58-08-2

  • Empirical Formula (Hill Notation) C8H10N4O2

  • Molecular Weight 194.19

  •  Beilstein Registry Number 17705

  •  EC Number 200-362-1

  •  MDL number MFCD00005758

  •  PubChem Substance ID 329823117

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards,
grade   certified reference material
  pharmaceutical secondary standard
InChI Key   RYYVLZVUVIJVGH-UHFFFAOYSA-N
form   neat
mp   234-236.5 °C(lit.)
  ~236 °C
format   neat
pharmacopeia traceability   traceable to USP 1086006

Description

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB0976 in the slot below. This is an example certificate only and may not be the lot that you receive.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
EV6475000
Protocols & Articles

Articles

GC Analysis of Basic Drugs on Equity®-5

From our library of Articles, Sigma-Aldrich presents GC Analysis of Basic Drugs on Equity®-5
Keywords: Chromatography, Gas chromatography, Purification

GC Analysis of Basic Drugs on SLB®-5ms

From our library of Articles, Sigma-Aldrich presents GC Analysis of Basic Drugs on SLB®-5ms
Keywords: Chromatography, Gas chromatography, Purification

HPLC Analysis of Acetaminophen, Caffeine, Chlorpheniramine, Ibuprofen, Naproxen, Phenylephrine, and Pseudoephedrine on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Acetaminophen, Caffeine, Chlorpheniramine, Ibuprofen, Naproxen, Phenylephrine, and Pseudoephedrine on Ascentis® Express C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical, Separation

HPLC Analysis of Antihypertensive and Diuretic Drugs on Discovery® RP-Amide C16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antihypertensive and Diuretic Drugs on Discovery® RP-Amide C16
Keywords: Antihypertensives, Chromatography, Clinical, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Beverage Additives in Diet Cola on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Beverage Additives in Diet Cola on Ascentis® Express C18
Keywords: Chromatography, High performance liquid chromatography, Separation

HPLC Analysis of Beverage Additives in Diet Cola on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Beverage Additives in Diet Cola on Ascentis® Express RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Separation

HPLC Analysis of Bronchodilators Theophylline and Other Caffeine Metabolites in Serum on Discovery® RP-AmideC16 after SPE using Discovery® DSC-18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Bronchodilators Theophylline and Other Caffeine Metabolites in Serum on Discovery® RP-AmideC16 after SPE using Discovery® DSC-18
Keywords: Calorimetry, Chromatography, Clinical, High performance liquid chromatography, Pharmaceutical, Sample preparations, Solid phase extractions

HPLC Analysis of Caffeine and Taurine on Ascentis® Express HILIC Column using Evaporative Light Scattering Detection (ELSD)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Caffeine and Taurine on Ascentis® Express HILIC Column using Evaporative Light Scattering Detection (ELSD)
Keywords: Chromatography, High performance liquid chromatography, Normal-phase chromatography, Separation, Vitamins

HPLC Analysis of Caffeine and Taurine on Ascentis® Express HILIC Column using Evaporative Light Scattering Detection (ELSD, Fast Analysis)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Caffeine and Taurine on Ascentis® Express HILIC Column using Evaporative Light Scattering Detection (ELSD, Fast Analysis)
Keywords: Chromatography, High performance liquid chromatography, Normal-phase chromatography, Separation, Vitamins

HPLC Analysis of Pain Relievers on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Pain Relievers on Ascentis® Express C18
Keywords: Analgesics, Chromatography, Clinical, High performance liquid chromatography

HPLC Analysis of an Energy Drink on Ascentis® Express HILIC (UV Detection)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of an Energy Drink on Ascentis® Express HILIC (UV Detection)
Keywords: Chromatography, Detection methods, High performance liquid chromatography, Separation, Vitamins

TLC Analysis of Analgesics on HPTLC Silica Gel 60 RP-18 WF254s (analyte set 2)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Analgesics on HPTLC Silica Gel 60 RP-18 WF254s (analyte set 2)
Keywords: Chromatography, Pharmaceutical, Thin layer chromatography

TLC Analysis of Analgesics on HPTLC Silica Gel 60 RP-18 WF254s (analyte set 2)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Analgesics on HPTLC Silica Gel 60 RP-18 WF254s (analyte set 2)
Keywords: Chromatography, Pharmaceutical, Thin layer chromatography

TLC Analysis of Expectorants on HPTLC Silica Gel 60 RP-18 WF254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Expectorants on HPTLC Silica Gel 60 RP-18 WF254s
Keywords: Chromatography, Pharmaceutical, Thin layer chromatography

Peer-Reviewed Papers
15

References

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