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PVP40 Sigma-Aldrich

Polyvinylpyrrolidone

average mol wt 40,000

Synonym: PVP, Polyvidone, Povidone

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Description

Application

Complexes with phenolics and alkaloids for their removal from plant samples, thus preventing their modification of proteins and any interference they may cause in spectrophotometric determinations of protein content. This is also reported to improve stability of enzymes.

Other Notes

Polyvinylpyrrolidone is a component of Denhardt′s Solution and is included at a concentration of 1% (w/v) in the standard 50X stock solution.

Packaging

1 kg in poly bottle

5 kg in poly drum

50, 100, 500 g in poly bottle

Price and Availability

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Safety & Documentation

Safety Information

WGK Germany 
1
RTECS 
TR8370000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Introduction to Southern and Northern Blotting

The transfer of macromolecules such as nucleic acids and proteins to solid-phase membranous support is termed as blotting. Fragments of DNA and RNA molecules separated by gel electrophoresis are tran...
Keywords: AGE, Buffers, Digestions, Electrophoresis, Gel electrophoresis, Nucleic acid hybridization, Precipitation, Purification, Scintillation, Separation, Size-exclusion chromatography, Sterilizations

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Peer-Reviewed Papers

References

Set your institution to view full text papers.

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Two-dimensional electrophoresis of acidic proteins isolated from ozone-stressed Norway spruce needles (Picea abies L Karst): separation method and image processing. Davidsen, N.B. Electrophoresis 16, 1305-1311, (1995)

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Role of tentacles and protein loading on pore accessibility and mass transfer in cation exchange materials for proteins. Thomas H, Coquebert de Neuville B, Storti G, et al. J. Chromatogr. A 1285, 48-56, (2013)

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[Gordon's polyvinylpyrrolidone test]. Aebersold J Helv. Med. Acta 32(3), 227-46, (1965)

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[Antimicrobial activity of stable silver nanoparticles of a certain size]. Mukha IuP, Eremenko AM, Smirnova NP, et al. Prikl. Biokhim. Mikrobiol. 49(2), 215-23, (2013)

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[Jumper's knee. Surgery and arthroscopic treatment with scraping and povidone collagen in high-performance athletes]. Cuéllar EC and Mina NZ Acta Ortop. Mex. 21(5), 234-8, (2007)

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A physiological replacement for polyvinylpyrrolidone (PVP) in assisted reproductive technology. Barak Y, Menezo Y, Veiga A, et al. Hum. Fertil. (Camb.) 4(2), 99-103, (2001)

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An investigation into the effect of spray drying temperature and atomizing conditions on miscibility, physical stability, and performance of naproxen-PVP K 25 solid dispersions. Paudel A, Loyson Y, and Van den Mooter G J. Pharm. Sci. 102(4), 1249-67, (2013)

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Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells. Murugappan Ramanathan et al Am. J. Rhinol. 22, 115-21, (2010)

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Solid dispersion of quercetin in cellulose derivative matrices influences both solubility and stability. Li B, Konecke S, Harich K, et al. Carbohydr. Polym. 92(2), 2033-40, (2013)

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Drug "supersaturation" states induced by polymeric micelles and liposomes: a mechanistic investigation into permeability enhancements. di Cagno M and Luppi B Eur. J. Pharm. Sci. 48(4-5), 775-80, (2013)

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Dissolution testing of amorphous solid dispersions. Kogermann K, Penkina A, Predbannikova K, et al. Int. J. Pharm. 444(1-2), 40-6, (2013)

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A method for nanofluidic device prototyping using elastomeric collapse. Seung-min Park et al Proc. Natl. Acad. Sci. U. S. A. 106, 15549-54, (2009)

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Silver nanoparticle toxicity to Daphnia magna is a function of dissolved silver concentration. Newton KM, Puppala HL, Kitchens CL, et al. Environ. Toxicol. Chem. 32(10), 2356-64, (2013)

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A systematic evaluation of agglomeration of Ag and TiO2 nanoparticles under freshwater relevant conditions. Topuz E, Sigg L, and Talinli I Environ. Pollut. 193, 37-44, (2014)

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CaMKII binding to GluN2B is differentially affected by macromolecular crowding reagents. Goodell DJ, Eliseeva TA, Coultrap SJ, et al. PLoS ONE 9(5), e96522, (2014)

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Large-scale and highly efficient synthesis of micro- and nano-fibers with controlled fiber morphology by centrifugal jet spinning for tissue regeneration. Ren L, Pandit V, Elkin J, et al. Nanoscale 5(6), 2337-45, (2013)

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Investigating oxidative stress and inflammatory responses elicited by silver nanoparticles using high-throughput reporter genes in HepG2 cells: effect of size, surface coating, and intracellular uptake. Prasad RY, McGee JK, Killius MG, et al. Toxicol. In Vitro 27(6), 2013-21, (2013)

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Comparing the effects of nanosilver size and coating variations on bioavailability, internalization, and elimination, using Lumbriculus variegatus. Coleman JG, Kennedy AJ, Bednar AJ, et al. Environ. Toxicol. Chem. 32(9), 2069-77, (2013)

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Modifying excitation light dose of novel photosensitizer PVP-Hypericin for photodynamic diagnosis and therapy. Penjweini R, Loew HG, Eisenbauer M, et al. J. Photochem. Photobiol. B, Biol. 120, 120-9, (2013)

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NIR imaging spectroscopy for quantification of constituents in polymers thin films loaded with paracetamol. Alexandrino GL and Poppi RJ Anal. Chim. Acta 765, 37-44, (2013)

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Polymer crowders and protein crowders act similarly on protein folding stability. Zhou HX FEBS Lett. 587(5), 394-7, (2013)

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Anaphylaxis to polyvinylpyrrolidone after vaginal application of povidone-iodine. Adachi A, Fukunaga A, Hayashi K, et al. Contact Dermatitis 48(3), 133-6, (2003)

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Phosphate-enhanced cytotoxicity of zinc oxide nanoparticles and agglomerates. Everett WN, Chern C, Sun D, et al. Toxicol. Lett. 225(1), 177-84, (2014)

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Folic acid-conjugated graphene oxide for cancer targeted chemo-photothermal therapy. Qin XC, Guo ZY, Liu ZM, et al. J. Photochem. Photobiol. B, Biol. 120, 156-62, (2013)

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Chemical and microbiologic characteristics and toxicity of povidone-iodine solutions. Zamora JL Am. J. Surg. 151(3), 400-6, (1986)

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Ultralow-limit gas detection in nano-dumbbell polymer sensor via electrospinning. Xue M, Li F, Wang Y, et al. Nanoscale 5(5), 1803-5, (2013)

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Water-soluble and biocompatible MnO@PVP nanoparticles for MR imaging in vitro and in vivo. Hu X, Ji Y, Wang M, et al. J. Biomed. Nanotechnol. 9(6), 976-84, (2013)

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Comprehensive analysis of alterations in the miRNome in response to photodynamic treatment. Bach D, Fuereder J, Karbiener M, et al. J. Photochem. Photobiol. B, Biol. 120, 74-81, (2013)

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Preparation of poly(phthalazinone-ether-sulfone) sponge-like ultrafiltration membrane. Qin P, Hong X, Karim MN, et al. Langmuir 29(12), 4167-75, (2013)

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Genotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in BEAS 2B cells. Nymark P, Catalán J, Suhonen S, et al. Toxicology 313(1), 38-48, (2013)

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Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration. Yamashita K, Yoshioka Y, Pan H, et al. Pharmazie 68(1), 54-7, (2013)

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Regulation of sodium and calcium in Daphnia magna exposed to silver nanoparticles. Zhao CM and Wang WX Environ. Toxicol. Chem. 32(4), 913-9, (2013)

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Mechanochemical activation of vincamine mediated by linear polymers: assessment of some "critical" steps. Hasa D, Perissutti B, Grassi M, et al. Eur. J. Pharm. Sci. 50(1), 56-68, (2013)

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Transport and accumulation of PVP-Hypericin in cancer and normal cells characterized by image correlation spectroscopy techniques. Penjweini R, Smisdom N, Deville S, et al. Biochim. Biophys. Acta 1843(5), 855-65, (2014)

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II. Technological approaches to improve the dissolution behavior of nateglinide, a lipophilic insoluble drug: co-milling. Maggi L, Bruni G, Maietta M, et al. Int. J. Pharm. 454(1), 568-72, (2013)

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The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia. Sanders, NM Am. J. Physiol. Endocrinol. Metab. 294(5), E853-60, (2008)

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Polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair): a bioadherent oral gel for the treatment of oral mucositis and other painful oral lesions. Buchsel PC Expert Opin. Drug Metab. Toxicol. 4(11), 1449-54, (2008)

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Synthesis and chirality control of bulk crystals and nanocrystals: from a right-handed nonpolar chain to a left-handed polar chain. Yin YY, Zhao YL, Ma JG, et al. Inorg. Chem. 52(7), 3738-43, (2013)

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Electromechanical resonator based on electrostatically actuated graphene-doped PVP nanofibers. Fardindoost S, Mohammadi S, Iraji zad A, et al. Nanotechnology 24(13), 135201, (2013)

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Effect of drug-polymer interactions on the aqueous solubility of milled solid dispersions. Al-Obaidi H, Lawrence MJ, Shah S, et al. Int. J. Pharm. 446(1-2), 100-5, (2013)

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Removal of polyvinylpyrrolidone from wastewater using different methods. Julinová M, Kupec J, Houser J, et al. Water Environ. Res. 84(12), 2123-32, (2012)

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Novel taste-masked orally disintegrating tablets for a highly soluble drug with an extremely bitter taste: design rationale and evaluation. Tan Q, Zhang L, Liu G, et al. Drug Dev. Ind. Pharm. 39(9), 1364-71, (2013)

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Solid dispersions of the penta-ethyl ester prodrug of diethylenetriaminepentaacetic acid (DTPA): formulation design and optimization studies. Yang YT, Di Pasqua AJ, Zhang Y, et al. Pharm. Dev. Technol. 19(7), 806-12, (2014)

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Fast disintegrating tablets of nisoldipine for intra-oral administration. El Maghraby GM and Elsergany RN Pharm. Dev. Technol. 19(6), 641-50, (2014)

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The influence of sodium salts (iodide, chloride and sulfate) on the formation efficiency of sulfamerazine nanocrystals. Lou H, Liu M, Qu W, et al. Pharm. Dev. Technol. 19(5), 548-55, (2014)

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A novel surface-attached carvedilol solid dispersion with enhanced solubility and dissolution. Lee SN, Poudel BK, Tran TH, et al. Arch. Pharm. Res. 36(1), 79-85, (2013)

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Solution growth of spherulitic rod and platelet calcium phosphate assemblies through polymer-assisted mesoscopic transformations. Kosma VA and Beltsios KG Mater. Sci. Eng. C. Mater. Biol. Appl. 33(4), 2175-91, (2013)

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Direct and indirect method of plant regeneration from root explants of Caesalpinia bonduc (L.) Roxb.--a threatened medicinal plant of Western Ghats. Kumar SR, Krishna V, Venkatesh, et al. Indian J. Exp. Biol. 50(12), 910-7, (2012)

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Composite nanofibers doped with a phosphorescent Re(I) complex having restricted conjugation plane in its diamine ligand: preparation, characterization, photophysical property and oxygen-sensing performance. Lin C, Shaoyan W, Qi W, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 114, 330-8, (2013)

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Removal of phenolic compounds from aqueous phase by adsorption onto polymer supported iron nanoparticles. Sen BK, Deshmukh DK, Deb MK, et al. Bull. Environ. Contam. Toxicol. 93(5), 549-54, (2014)

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Powder flow in an automated uniaxial tester and an annular shear cell: a study of pharmaceutical excipients and analytical data comparison. Kuentz M and Schirg P Drug Dev. Ind. Pharm. 39(9), 1476-83, (2013)

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Formulation and evaluation of clozapine orally disintegrating tablets prepared by direct compression. Olmez SS, Vural I, Sahin S, et al. Pharmazie 68(2), 110-6, (2013)

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Curcumin amorphous solid dispersions: the influence of intra and intermolecular bonding on physical stability. Wegiel LA, Zhao Y, Mauer LJ, et al. Pharm. Dev. Technol. 19(8), 976-86, (2014)

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Preparation, characterization and tableting of cilnidipine solid dispersions. Hu L, Song W, Niu F, et al. Pak. J. Pharm. Sci. 26(3), 629-36, (2013)

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A non-destructive genotyping system from a single seed for marker-assisted selection in watermelon. Meru G, McDowell D, Waters V, et al. Genet. Mol. Res. 12(1), 702-9, (2013)

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Polyvinylpyrrolidone (PVP), its diagnostic, therapeutic and technical application and consequences thereof. Wessel W, Schoog M, and Winkler E Arzneimittelforschung 21(10), 1468-82, (1971)

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Povidone-iodine solutions in traumatic wound preparation. Oberg MS Am. J. Emerg. Med. 5(6), 553-5, (1987)

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Merck 14,7697

Aldrich MSDS 1, 1530:C / Corp MSDS 1 (2), 2892:D / FT-IR 2 (3), 4701:D / FT-IR 1 (2), 1202:C / FT-IR 1 (2), 1202:D / FT-IR 2 (3), 4702:B / FT-IR 1 (2), 1202:A / FT-IR 2 (3), 4702:A / IR-Spectra (3), 1592:F / IR-Spectra (2), 1354:G / IR-Spectra (2), 1354:F / IR-Spectra (3), 1592:D / IR-Spectra (3), 1592:E / RegBook 1 (2), 3171:F / Sax 6, 2265 / Sigma FT-IR 1 (1), 702:A / Sigma FT-IR 1 (1), 701:D / Structure Index 1, 504:B:1

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