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PVP40 Sigma-Aldrich

Polyvinylpyrrolidone

average mol wt 40,000

Synonym: PVP, Polyvidone, Povidone

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Description

Application

Complexes with phenolics and alkaloids for their removal from plant samples, thus preventing their modification of proteins and any interference they may cause in spectrophotometric determinations of protein content. This is also reported to improve stability of enzymes.

Other Notes

Polyvinylpyrrolidone is a component of Denhardt′s Solution and is included at a concentration of 1% (w/v) in the standard 50X stock solution.

Packaging

1 kg in poly bottle

5 kg in poly drum

50, 100, 500 g in poly bottle

Price and Availability

TruPAGE™ Pre-cast Polyacrylamide Gels


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Custom Polymer Synthesis

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Safety & Documentation

Safety Information

WGK Germany 
1
RTECS 
TR8370000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Introduction to Southern and Northern Blotting

The transfer of macromolecules such as nucleic acids and proteins to solid-phase membranous support is termed as blotting. Fragments of DNA and RNA molecules separated by gel electrophoresis are tran...
Keywords: AGE, Buffers, Digestions, Electrophoresis, Gel electrophoresis, Nucleic acid hybridization, Precipitation, Purification, Scintillation, Separation, Size-exclusion chromatography, Sterilizations

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Peer-Reviewed Papers

References

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[Gordon's polyvinylpyrrolidone test]. Aebersold J Helv. Med. Acta 32(3), 227-46, (1965)

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Removal of phenolic compounds from aqueous phase by adsorption onto polymer supported iron nanoparticles. Sen BK, Deshmukh DK, Deb MK, et al. Bull. Environ. Contam. Toxicol. 93(5), 549-54, (2014)

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A systematic evaluation of agglomeration of Ag and TiO2 nanoparticles under freshwater relevant conditions. Topuz E, Sigg L, and Talinli I Environ. Pollut. 193, 37-44, (2014)

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[Antimicrobial activity of stable silver nanoparticles of a certain size]. Mukha IuP, Eremenko AM, Smirnova NP, et al. Prikl. Biokhim. Mikrobiol. 49(2), 215-23, (2013)

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Role of tentacles and protein loading on pore accessibility and mass transfer in cation exchange materials for proteins. Thomas H, Coquebert de Neuville B, Storti G, et al. J. Chromatogr. A 1285, 48-56, (2013)

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Electromechanical resonator based on electrostatically actuated graphene-doped PVP nanofibers. Fardindoost S, Mohammadi S, Iraji zad A, et al. Nanotechnology 24(13), 135201, (2013)

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[Jumper's knee. Surgery and arthroscopic treatment with scraping and povidone collagen in high-performance athletes]. Cuéllar EC and Mina NZ Acta Ortop. Mex. 21(5), 234-8, (2007)

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A physiological replacement for polyvinylpyrrolidone (PVP) in assisted reproductive technology. Barak Y, Menezo Y, Veiga A, et al. Hum. Fertil. (Camb.) 4(2), 99-103, (2001)

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Drug "supersaturation" states induced by polymeric micelles and liposomes: a mechanistic investigation into permeability enhancements. di Cagno M and Luppi B Eur. J. Pharm. Sci. 48(4-5), 775-80, (2013)

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Modifying excitation light dose of novel photosensitizer PVP-Hypericin for photodynamic diagnosis and therapy. Penjweini R, Loew HG, Eisenbauer M, et al. J. Photochem. Photobiol. B, Biol. 120, 120-9, (2013)

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A method for nanofluidic device prototyping using elastomeric collapse. Seung-min Park et al Proc. Natl. Acad. Sci. U. S. A. 106, 15549-54, (2009)

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Ultralow-limit gas detection in nano-dumbbell polymer sensor via electrospinning. Xue M, Li F, Wang Y, et al. Nanoscale 5(5), 1803-5, (2013)

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Effect of drug-polymer interactions on the aqueous solubility of milled solid dispersions. Al-Obaidi H, Lawrence MJ, Shah S, et al. Int. J. Pharm. 446(1-2), 100-5, (2013)

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NIR imaging spectroscopy for quantification of constituents in polymers thin films loaded with paracetamol. Alexandrino GL and Poppi RJ Anal. Chim. Acta 765, 37-44, (2013)

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Preparation of poly(phthalazinone-ether-sulfone) sponge-like ultrafiltration membrane. Qin P, Hong X, Karim MN, et al. Langmuir 29(12), 4167-75, (2013)

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Genotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in BEAS 2B cells. Nymark P, Catalán J, Suhonen S, et al. Toxicology 313(1), 38-48, (2013)

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CaMKII binding to GluN2B is differentially affected by macromolecular crowding reagents. Goodell DJ, Eliseeva TA, Coultrap SJ, et al. PLoS ONE 9(5), e96522, (2014)

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Comparing the effects of nanosilver size and coating variations on bioavailability, internalization, and elimination, using Lumbriculus variegatus. Coleman JG, Kennedy AJ, Bednar AJ, et al. Environ. Toxicol. Chem. 32(9), 2069-77, (2013)

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Polymer crowders and protein crowders act similarly on protein folding stability. Zhou HX FEBS Lett. 587(5), 394-7, (2013)

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Silver nanoparticle toxicity to Daphnia magna is a function of dissolved silver concentration. Newton KM, Puppala HL, Kitchens CL, et al. Environ. Toxicol. Chem. 32(10), 2356-64, (2013)

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Comprehensive analysis of alterations in the miRNome in response to photodynamic treatment. Bach D, Fuereder J, Karbiener M, et al. J. Photochem. Photobiol. B, Biol. 120, 74-81, (2013)

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Large-scale and highly efficient synthesis of micro- and nano-fibers with controlled fiber morphology by centrifugal jet spinning for tissue regeneration. Ren L, Pandit V, Elkin J, et al. Nanoscale 5(6), 2337-45, (2013)

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Synthesis and chirality control of bulk crystals and nanocrystals: from a right-handed nonpolar chain to a left-handed polar chain. Yin YY, Zhao YL, Ma JG, et al. Inorg. Chem. 52(7), 3738-43, (2013)

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An investigation into the effect of spray drying temperature and atomizing conditions on miscibility, physical stability, and performance of naproxen-PVP K 25 solid dispersions. Paudel A, Loyson Y, and Van den Mooter G J. Pharm. Sci. 102(4), 1249-67, (2013)

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Detecting phase separation of freeze-dried binary amorphous systems using pair-wise distribution function and multivariate data analysis. Chieng N, Trnka H, Boetker J, et al. Int. J. Pharm. 454(1), 167-73, (2013)

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Dissolution testing of amorphous solid dispersions. Kogermann K, Penkina A, Predbannikova K, et al. Int. J. Pharm. 444(1-2), 40-6, (2013)

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Folic acid-conjugated graphene oxide for cancer targeted chemo-photothermal therapy. Qin XC, Guo ZY, Liu ZM, et al. J. Photochem. Photobiol. B, Biol. 120, 156-62, (2013)

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Anaphylaxis to polyvinylpyrrolidone after vaginal application of povidone-iodine. Adachi A, Fukunaga A, Hayashi K, et al. Contact Dermatitis 48(3), 133-6, (2003)

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Mechanochemical activation of vincamine mediated by linear polymers: assessment of some "critical" steps. Hasa D, Perissutti B, Grassi M, et al. Eur. J. Pharm. Sci. 50(1), 56-68, (2013)

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II. Technological approaches to improve the dissolution behavior of nateglinide, a lipophilic insoluble drug: co-milling. Maggi L, Bruni G, Maietta M, et al. Int. J. Pharm. 454(1), 568-72, (2013)

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Water-soluble and biocompatible MnO@PVP nanoparticles for MR imaging in vitro and in vivo. Hu X, Ji Y, Wang M, et al. J. Biomed. Nanotechnol. 9(6), 976-84, (2013)

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Removal of polyvinylpyrrolidone from wastewater using different methods. Julinová M, Kupec J, Houser J, et al. Water Environ. Res. 84(12), 2123-32, (2012)

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Polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair): a bioadherent oral gel for the treatment of oral mucositis and other painful oral lesions. Buchsel PC Expert Opin. Drug Metab. Toxicol. 4(11), 1449-54, (2008)

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Investigating oxidative stress and inflammatory responses elicited by silver nanoparticles using high-throughput reporter genes in HepG2 cells: effect of size, surface coating, and intracellular uptake. Prasad RY, McGee JK, Killius MG, et al. Toxicol. In Vitro 27(6), 2013-21, (2013)

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Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration. Yamashita K, Yoshioka Y, Pan H, et al. Pharmazie 68(1), 54-7, (2013)

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Curcumin amorphous solid dispersions: the influence of intra and intermolecular bonding on physical stability. Wegiel LA, Zhao Y, Mauer LJ, et al. Pharm. Dev. Technol. 19(8), 976-86, (2014)

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Phosphate-enhanced cytotoxicity of zinc oxide nanoparticles and agglomerates. Everett WN, Chern C, Sun D, et al. Toxicol. Lett. 225(1), 177-84, (2014)

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Solution growth of spherulitic rod and platelet calcium phosphate assemblies through polymer-assisted mesoscopic transformations. Kosma VA and Beltsios KG Mater. Sci. Eng. C. Mater. Biol. Appl. 33(4), 2175-91, (2013)

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A novel surface-attached carvedilol solid dispersion with enhanced solubility and dissolution. Lee SN, Poudel BK, Tran TH, et al. Arch. Pharm. Res. 36(1), 79-85, (2013)

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Powder flow in an automated uniaxial tester and an annular shear cell: a study of pharmaceutical excipients and analytical data comparison. Kuentz M and Schirg P Drug Dev. Ind. Pharm. 39(9), 1476-83, (2013)

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Novel taste-masked orally disintegrating tablets for a highly soluble drug with an extremely bitter taste: design rationale and evaluation. Tan Q, Zhang L, Liu G, et al. Drug Dev. Ind. Pharm. 39(9), 1364-71, (2013)

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A non-destructive genotyping system from a single seed for marker-assisted selection in watermelon. Meru G, McDowell D, Waters V, et al. Genet. Mol. Res. 12(1), 702-9, (2013)

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Preparation, characterization and tableting of cilnidipine solid dispersions. Hu L, Song W, Niu F, et al. Pak. J. Pharm. Sci. 26(3), 629-36, (2013)

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Formulation and evaluation of clozapine orally disintegrating tablets prepared by direct compression. Olmez SS, Vural I, Sahin S, et al. Pharmazie 68(2), 110-6, (2013)

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Polyvinylpyrrolidone (PVP), its diagnostic, therapeutic and technical application and consequences thereof. Wessel W, Schoog M, and Winkler E Arzneimittelforschung 21(10), 1468-82, (1971)

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Povidone-iodine solutions in traumatic wound preparation. Oberg MS Am. J. Emerg. Med. 5(6), 553-5, (1987)

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Transport and accumulation of PVP-Hypericin in cancer and normal cells characterized by image correlation spectroscopy techniques. Penjweini R, Smisdom N, Deville S, et al. Biochim. Biophys. Acta 1843(5), 855-65, (2014)

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Fast disintegrating tablets of nisoldipine for intra-oral administration. El Maghraby GM and Elsergany RN Pharm. Dev. Technol. 19(6), 641-50, (2014)

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The influence of sodium salts (iodide, chloride and sulfate) on the formation efficiency of sulfamerazine nanocrystals. Lou H, Liu M, Qu W, et al. Pharm. Dev. Technol. 19(5), 548-55, (2014)

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Merck 14,7697

Aldrich MSDS 1, 1530:C / Corp MSDS 1 (2), 2892:D / FT-IR 2 (3), 4701:D / FT-IR 1 (2), 1202:C / FT-IR 1 (2), 1202:D / FT-IR 2 (3), 4702:B / FT-IR 1 (2), 1202:A / FT-IR 2 (3), 4702:A / IR-Spectra (3), 1592:F / IR-Spectra (2), 1354:G / IR-Spectra (2), 1354:F / IR-Spectra (3), 1592:D / IR-Spectra (3), 1592:E / RegBook 1 (2), 3171:F / Sax 6, 2265 / Sigma FT-IR 1 (1), 702:A / Sigma FT-IR 1 (1), 701:D / Structure Index 1, 504:B:1

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