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S6014 Sigma-Aldrich

Sodium bicarbonate

ACS reagent, ≥99.7%

Synonym: Sodium hydrogen carbonate

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Properties

Related Categories ACS Grade Buffers, Biochemicals and Reagents, Biological Buffers, Buffers A to Z, Chemical Synthesis,
Quality Level   PREMIUM
grade   ACS reagent
assay   ≥99.7%
  99.7-100.3%
impurities   ≤0.015% Insoluble matter
pKa (25 °C)   (1) 6.37, (2) 10.25 (carbonic acid)
anion traces   chloride (Cl-): ≤0.003%
  phosphate (PO43-): ≤0.001%
  sulfur compounds (as SO42-): ≤0.003%
cation traces   Ca: ≤0.02%
  Fe: ≤0.001%
  K: ≤0.005%
  Mg: ≤0.005%
  NH4+: ≤5 ppm
  heavy metals (as Pb): ≤5 ppm

Description

Packaging

12, 50 kg in poly drum

Legal Information

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

Other Notes

Go to Redi-Dri Product Listing 792519

Price and Availability

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Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



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Ultra-high Purity Salts

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Safety & Documentation

Safety Information

WGK Germany 
1
RTECS 
VZ0950000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

AOAC First Action Official Method℠ 2015.02

Determination of Sodium Monofluoroacetate in Dairy Powders by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Rodenticides

Determination of Water Content in Sodium hydrogen carbonate Using Karl Fischer Titration

KF solutions react slightly acidic and can dissolve oxides, hydroxides and carbonates. This leads to formation of water which also gets titrated. Individual oxides or carbonates react, however, in di...
Keywords: Titrations

Protocols

Enzymatic Assay of D-Alanine Racemase (EC 5.1.1.1)

1. OBJECTIVE To standardize a procedure for the enzymatic assay of D-Alanine Racemase, Sigma Product Number A8936, at Sigma-Aldrich St. Louis.
Keywords: Extinction coefficient

Peer-Reviewed Papers

References

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Inhibition of the š‘-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives? Peter Burghout et al Bioorg. Med. Chem. 19, 243-8, (2011)

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Systematic review: sodium bicarbonate treatment regimens for the prevention of contrast-induced nephropathy. Zoungas S, Ninomiya T, Huxley R, et al. Ann. Intern. Med. 151(9), 631-8, (2009)

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Sodium bicarbonate infusion to reduce cardiac surgery-associated acute kidney injury: a phase II multicenter double-blind randomized controlled trial. McGuinness SP, Parke RL, Bellomo R, et al. Crit. Care Med. 41(7), 1599-607, (2013)

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Sodium bicarbonate for prevention of contrast-induced acute kidney injury: a systematic review and meta-analysis. Hoste EA, De Waele JJ, Gevaert SA, et al. Nephrol. Dial. Transplant. 25(3), 747-58, (2010)

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Sodium bicarbonate for the prevention of contrast induced-acute kidney injury: a systematic review and meta-analysis. Brar SS, Hiremath S, Dangas G, et al. Clin. J. Am. Soc. Nephrol. 4(10), 1584-92, (2009)

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Prophylactic perioperative sodium bicarbonate to prevent acute kidney injury following open heart surgery: a multicenter double-blinded randomized controlled trial. Haase M, Haase-Fielitz A, Plass M, et al. PLoS Med. 10(4), e1001426, (2013)

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The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice. Rennel E Br. J. Cancer 98(7), 1250-7, (2008)

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Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Alessio Innocenti et al Bioorg. Med. Chem. Lett. 15, 573-8, (2005)

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Sodium bicarbonate use in shock and cardiac arrest: attitudes of pediatric acute care physicians. Parker MJ and Parshuram CS Crit. Care Med. 41(9), 2188-95, (2013)

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Regulation of two renal chloride transporters, AE1 and pendrin, by electrolytes and aldosterone. Mohebbi N, Perna A, van der Wijst J, et al. PLoS ONE 8(1), e55286, (2013)

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Acid-base problems in diabetic ketoacidosis. Kamel KS and Halperin ML N. Engl. J. Med. 372(6), 546-54, (2015)

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A protocol for the management of adhesive small bowel obstruction. Loftus T, Moore F, VanZant E, et al. J. Trauma Acute Care Surg. 78(1), 13-9; discussion 19-21, (2015)

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Lactic acidosis. Kraut JA and Madias NE N. Engl. J. Med. 371(24), 2309-19, (2014)

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[Transition of acetylsalicylic acid serum concentration in a case of overdose]. Tominaga A Chudoku. Kenkyu. 26(4), 314-5, (2013)

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Effect of oral care solutions in reducing ventilator-associated pneumonia: review of current evidence. Balamurugan E and Dileep ET Nurs. J. India 103(6), 282-4, (2012)

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Case files of the University of California San Francisco Medical Toxicology Fellowship: acute chlorine gas inhalation and the utility of nebulized sodium bicarbonate. Vajner JE and Lung D J. Med. Toxicol. 9(3), 259-65, (2013)

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Sodium acetate as a replacement for sodium bicarbonate in medical toxicology: a review. Neavyn MJ, Boyer EW, Bird SB, et al. J. Med. Toxicol. 9(3), 250-4, (2013)

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Sjogren's syndrome presenting with hypokalemic periodic paralysis. Agrawal S, Bharti V, Jain MN, et al. J. Assoc. Physicians India 60, 55-6, (2012)

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[Experimental justification of approaches to pharmacological correction of delayed disorders caused by acute ethylene glycol poisoning]. Liubishin MM, Sivak KV, and Savateeva-Liubimova TN Eksp. Klin. Farmakol. 75(11), 31-4, (2012)

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Gingival pain: an unusual side effect of ziprasidone. Raghunath A BMJ Case Rep. 2013, doi:10.1136/bcr-2012-007577, (2013)

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Sodium bicarbonate use in the treatment of acute neonatal lactic acidosis: benefit or harm? Johnson PJ Neonatal Netw. 30(3), 199-205, (2011)

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Prevention of contrast-induced nephropathy: the rational use of sodium bicarbonate. Barreto R Nephrol. Nurs. J. 34(4), 417-21, (2007)

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Management of the cardiovascular complications of tricyclic antidepressant poisoning : role of sodium bicarbonate. Bradberry SM, Thanacoody HK, Watt BE, et al. Toxicol. Rev. 24(3), 195-204, (2005)

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Spectrophotometric determination of drugs with iodine. Karuna T, et al. J. Sci. Ind. Res. 65(10), 808, (2006)

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The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters. Parker MD and Boron WF Physiol. Rev. 93(2), 803-959, (2013)

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The effect of sodium bicarbonate upon urinary citrate excretion in calcium stone formers. Pinheiro VB, Baxmann AC, Tiselius HG, et al. Urology 82(1), 33-7, (2013)

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Acidity generated by the tumor microenvironment drives local invasion. Estrella V, Chen T, Lloyd M, et al. Cancer Res. 73(5), 1524-35, (2013)

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Inhibition studies with anions and small molecules of two novel α-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium. Daniela Vullo et al Bioorg. Med. Chem. Lett. 21, 3591-5, (2011)

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Is there a role for sodium bicarbonate in treating lactic acidosis from shock? Boyd JH and Walley KR Curr. Opin. Crit. Care 14(4), 379-83, (2008)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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A comparison of treating metabolic acidosis in CKD stage 4 hypertensive kidney disease with fruits and vegetables or sodium bicarbonate. Goraya N, Simoni J, Jo CH, et al. Clin. J. Am. Soc. Nephrol. 8(3), 371-81, (2013)

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Sodium bicarbonate therapy for prevention of contrast-induced nephropathy: a systematic review and meta-analysis. Navaneethan SD, Singh S, Appasamy S, et al. Am. J. Kidney Dis. 53(4), 617-27, (2009)

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Sodium bicarbonate: basically useless therapy. Aschner JL and Poland RL Pediatrics 122(4), 831-5, (2008)

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Sodium bicarbonate plus N-acetylcysteine prophylaxis: a meta-analysis. Brown JR, Block CA, Malenka DJ, et al. JACC Cardiovasc. Interv. 2(11), 1116-24, (2009)

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Can neutrophil gelatinase-associated lipocalin help depict early contrast material-induced nephropathy? Lacquaniti A, Buemi F, Lupica R, et al. Radiology 267(1), 86-93, (2013)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Sodium bicarbonate and high-intensity-cycling capacity: variability in responses. Saunders B, Sale C, Harris RC, et al. Int. J. Sports Physiol. Perform. 9(4), 627-32, (2014)

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Effect of sodium bicarbonate supplementation on 2000-m rowing performance. Hobson RM, Harris RC, Martin D, et al. Int. J. Sports Physiol. Perform. 9(1), 139-44, (2014)

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Sodium bicarbonate therapy for the prevention of contrast-induced acute kidney injury – a systematic review and meta-analysis –. Jang JS, Jin HY, Seo JS, et al. Circ. J. 76(9), 2255-65, (2012)

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N-acetylcysteine plus intravenous fluids versus intravenous fluids alone to prevent contrast-induced nephropathy in emergency computed tomography. Traub SJ, Mitchell AM, Jones AE, et al. Ann. Emerg. Med. 62(5), 511-520.e25, (2013)

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Does correction of metabolic acidosis slow chronic kidney disease progression? Goraya N and Wesson DE Curr. Opin. Nephrol. Hypertens. 22(2), 193-7, (2013)

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Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis. Harada K, Shimoda S, Sato Y, et al. Clin. Exp. Immunol. 157(2), 261-70, (2009)

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Ergogenic effects of sodium bicarbonate. McNaughton LR, Siegler J, and Midgley A Curr. Sports Med. Rep. 7(4), 230-6, (2008)

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Synthesis of stable phosphomide ligands and their use in Ru-catalyzed hydrogenations of bicarbonate and related substrates. Gowrisankar S, Federsel C, Neumann H, et al. ChemSusChem 6(1), 85-91, (2013)

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Practical recommendations for coaches and athletes: a meta-analysis of sodium bicarbonate use for athletic performance. Peart DJ, Siegler JC, and Vince RV J. Strength Cond. Res. 26(7), 1975-83, (2012)

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Transcriptome exploration in Leymus chinensis under saline-alkaline treatment using 454 pyrosequencing. Sun Y, Wang F, Wang N, et al. PLoS ONE 8(1), e53632, (2013)

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The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cells. Eder-Colli L Brain Res. Bull. 80(4-5), 296-301, (2009)

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Prevention of kidney injury following rhabdomyolysis: a systematic review. Scharman EJ and Troutman WG Ann. Pharmacother. 47(1), 90-105, (2013)

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Intravenous lipid emulsion-augmented plasma exchange in a rabbit model of clomipramine toxicity; survival, but no sink. Harvey M, Cave G, and Ong B Clin. Toxicol. (Phila.) 52(1), 13-9, (2014)

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Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii. Alessandra Cincinelli et al Bioorg. Med. Chem. 19, 1847-51, (2011)

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Effects of combined creatine and sodium bicarbonate supplementation on repeated sprint performance in trained men. Barber JJ, McDermott AY, McGaughey KJ, et al. J. Strength Cond. Res. 27(1), 252-8, (2013)

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Clinical, microbiological and histological findings in lambs affected by 'salivary abomasum disease'. Christodoulopoulos G, Scott PR, Jehl N, et al. Vet. Rec. 172(4), 100, (2013)

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Single early instillation of mitomycin C and urinary alkalinization in low-risk non-muscle-invasive bladder cancer: a preliminary study. Ersoy H, Yaytokgil M, Karakoyunlu AN, et al. Drug Des. Devel. Ther. 7, 1-6, (2013)

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Use of high-dose epinephrine and sodium bicarbonate during neonatal resuscitation: is there proven benefit? Wyckoff MH and Perlman JM Clin. Perinatol. 33(1), 141-51, viii-ix, (2006)

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Prevention of acute renal failure post-contrast imaging in cardiology: a randomized study. Alessandri N, Lanzi L, Garante CM, et al. Eur. Rev. Med. Pharmacol. Sci. 17 Suppl 1, 13-21, (2013)

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Efficacy of urine alkalinization by oral administration of sodium bicarbonate: a prospective open-label trial. Cohen B, Laish I, Brosh-Nissimov T, et al. Am. J. Emerg. Med. 31(12), 1703-6, (2013)

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Polycyclic aromatic hydrocarbon removal from petroleum sludge cake using thermal treatment with additives. Pakpahan EN, Isa MH, Kutty SR, et al. Environ. Technol. 34(1-4), 407-16, (2013)

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Efficient extra- and intracellular alkalinization improves cardiovascular functions in severe lactic acidosis induced by hemorrhagic shock. Kimmoun A, Ducrocq N, Sennoun N, et al. Anesthesiology 120(4), 926-34, (2014)

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Anion inhibition studies of an α-carbonic anhydrase from the living fossil Astrosclera willeyana. Anna Ohradanova et al Bioorg. Med. Chem. Lett. 22, 1314-6, (2012)

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Prophylactic administration of bicarbonate to reduce the risk of postcardiac surgery acute kidney injury: end of the road?. Thakar CV and Leonard AC Crit. Care Med. 41(7), 1802-3, (2013)

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Hypertonic sodium bicarbonate versus intravenous lipid emulsion in a rabbit model of intravenous flecainide toxicity: no difference, no sink. Cave G, Harvey M, Quinn P, et al. Clin. Toxicol. (Phila.) 51(5), 394-7, (2013)

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Combined effect of glycation and sodium carbonate-bicarbonate buffer concentration on IgG binding, IgE binding and conformation of ovalbumin. Ma XJ, Gao JY, and Chen HB J. Sci. Food Agric. 93(13), 3209-15, (2013)

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Clinical characteristics of patients after dicamba herbicide ingestion. Moon JM and Chun BJ Clin. Toxicol. (Phila.) 52(1), 48-53, (2014)

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Cloning and expression of a small heat and salt tolerant protein (Hsp22) from Chaetomium globosum. Aggarwal R, Gupta S, Sharma S, et al. Indian J. Exp. Biol. 50(11), 826-32, (2012)

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Formulation and in vitro assessment of sustained release terbutaline sulfate tablet made from binary hydrophilic polymer mixtures. Al-Akayleh F, Al Remawi M, Rashid I, et al. Pharm. Dev. Technol. 18(5), 1204-12, (2013)

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Effect of 5/6 nephrectomized rat serum on epithelial-to-mesenchymal transition in vitro. Lu Z Ren. Fail. 33(6), 600-8, (2011)

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Effect of alkalinisation of lignocaine for propofol injection pain: a prospective, randomised, double-blind study. Ozgul U, Begec Z, Erdogan MA, et al. Anaesth. Intensive Care 41(4), 501-4, (2013)

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Sodium bicarbonate infusion during resuscitation of infants at birth. Beveridge CJ and Wilkinson AR Cochrane Database Syst. Rev. (1), CD004864, (2006)

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Effects of bicarbonate on oxyhaemoglobin desaturation and exercise performance in athletes. Do Valle Bargieri J, Berton DC, Aparecido De Almeida A, et al. J. Sports Med. Phys. Fitness 53(5), 470-6, (2013)

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Should local anesthetic bladder cocktails include sodium bicarbonate? Yes. Parsons CL J. Urol. 191(4), 895-6, (2014)

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Should local anesthetic bladder cocktails include sodium bicarbonate? No. Butrick CW J. Urol. 191(4), 896-7, (2014)

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Oesophageal bezoar induced by black beans successfully removed by associating endoscopy and oral sodium bicarbonate. Chen MY and Ying ZQ Acta Gastroenterol. Belg. 76(3), 347, (2013)

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Sodium bicarbonate--the swings and roundabouts will not stop without randomized evidence. Simma B and Kirpalani H Crit. Care Med. 41(9), 2242-3, (2013)

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Novel approach for colonic insufflation via an untethered capsule (with video). Obstein KL, Battaglia S, Smith BF, et al. Gastrointest. Endosc. 77(3), 516-7, (2013)

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Treatment of acidosis in CKD. Yaqoob MM Clin. J. Am. Soc. Nephrol. 8(3), 342-3, (2013)

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Sodium bicarbonate use in acute kidney injury. Uniacke MD, Venkat Raman G, and Hewitt J Am. J. Kidney Dis. 61(3), 523, (2013)

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Sodium bicarbonate supplements for treating acute kidney injury. Hewitt J, Uniacke M, Hansi NK, et al. Cochrane Database Syst. Rev. 6, CD009204, (2012)

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Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bet 1. Rhabdomyolysis and the use of sodium bicarbonate and/or mannitol. Thomas R Emerg. Med. J. 27(4), 305-8, (2010)

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Best evidence topic report. Treatment of jellyfish stings in UK coastal waters: vinegar or sodium bicarbonate? Prestwich H and Jenner R Emerg. Med. J. 24(9), 664, (2007)

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Merck 14,8583

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