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T7645 Sigma-Aldrich

Tetracaine hydrochloride

Sigma Reference Standard

Synonym: 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester, Amethocaine hydrochloride

  • CAS Number 136-47-0

  • Empirical Formula (Hill Notation) C15H24N2O2 · HCl

  • Molecular Weight 300.82

  •  MDL number MFCD00038912

  •  PubChem Substance ID 329826873

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Properties

Related Categories Calcium Channel Modulators, Cell Biology, Cell Signaling and Neuroscience, Inhibitors and Activators, Ion Channels,
grade   Sigma Reference Standard
InChI Key   PPWHTZKZQNXVAE-UHFFFAOYSA-N
packaging   vial of 250 mg
solubility   alcohol: solublesoluble in 40 parts solvent
  chloroform: solublesoluble in 30 parts of solvent
  H2O: soluble50 mg/mL, clear, colorless
  acetone: insoluble
  benzene: insoluble
  diethyl ether: insoluble

Description

Application

Topical ophthalmic anesthetic; used for spinal anesthesia

Tetracaine hydrochloride has been used to analyze Ca2+ release from sarcoplasmic reticulum (SR) in neonatal ventricular cardiomyocytes (NVCMs). Tetracaine hydrochloride has also been used as a component of protease digestion buffers.

Biochem/physiol Actions

Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.

Packaging

Supplied in amber screw-cap vials

Preparation Note

Tetracaine hydrochloride dissolves in water at 50 mg/ml to yield a clear, colorless solution. It is also soluble in 40 parts alcohol and 30 parts chloroform. However, it is practically insoluble in ether benzene or acetone.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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