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T7645 Sigma-Aldrich

Tetracaine hydrochloride

Sigma Reference Standard

Synonym: 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester, Amethocaine hydrochloride

  • CAS Number 136-47-0

  • Empirical Formula (Hill Notation) C15H24N2O2 · HCl

  • Molecular Weight 300.82

  •  MDL number MFCD00038912

  •  PubChem Substance ID 329826873

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Properties

Related Categories Calcium Channel Modulators, Cell Biology, Cell Signaling and Neuroscience, Inhibitors and Activators, Ion Channels,
grade   Sigma Reference Standard
InChI Key   PPWHTZKZQNXVAE-UHFFFAOYSA-N
packaging   vial of 250 mg
solubility   alcohol: solublesoluble in 40 parts solvent
  chloroform: solublesoluble in 30 parts of solvent
  H2O: soluble50 mg/mL, clear, colorless
  acetone: insoluble
  benzene: insoluble
  diethyl ether: insoluble

Description

Application

Topical ophthalmic anesthetic; used for spinal anesthesia

Tetracaine hydrochloride has been used to analyze Ca2+ release from sarcoplasmic reticulum (SR) in neonatal ventricular cardiomyocytes (NVCMs). Tetracaine hydrochloride has also been used as a component of protease digestion buffers.

Biochem/physiol Actions

Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.

Packaging

Supplied in amber screw-cap vials

Preparation Note

Tetracaine hydrochloride dissolves in water at 50 mg/ml to yield a clear, colorless solution. It is also soluble in 40 parts alcohol and 30 parts chloroform. However, it is practically insoluble in ether benzene or acetone.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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