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00189 Sigma

Sulfadimidine solution

1 mg/mL in H2O

Synonym: Sulfamethazine solution

  • CAS Number 57-68-1

  • Empirical Formula (Hill Notation) C12H14N4O2S

  • Molecular Weight 278.33

  •  Beilstein Registry Number 261304

  •  MDL number MFCD00006066

  •  PubChem Substance ID 24844985

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Biochemicals and Reagents
InChI Key   ASWVTGNCAZCNNR-UHFFFAOYSA-N
concentration   1 mg/mL in H2O
Mode of action   enzyme | inhibits
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria

Description

Application

Sulfadimidine is used to induce cytochrome P450 3A4 (CYP3A4) and to inhibit dihydrofolate reductase (DHFR). It was used to study amantadine acetylation.

Biochem/physiol Actions

Sulfadimidine is a competitive inhibitor of dihydropteroate synthetase to block the synthesis of folic acid. It acts as an inhibitor of dihydrofolate reductase (DHFR).

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Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
nwg

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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