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01673 Sigma

Acriflavine

BioReagent, suitable for fluorescence, ≥95.0% (AT)

Synonym: 3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-diaminoacridine (proflavine), Euflavine, Trypaflavine Neutral

  • CAS Number 8048-52-0

  • Empirical Formula (Hill Notation) C14H14ClN3

  • Molecular Weight 259.73

  •  MDL number MFCD00064307

  •  PubChem Substance ID 329747342

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Properties

Related Categories Alphabetical, Biochemicals and Reagents, Detection, Fluorescent Probes, Labels, Particles and Stains, Fluorescent Stains,
InChI Key   PEJLNXHANOHNSU-UHFFFAOYSA-N
product line   BioReagent
assay   ≥95.0% (AT)
composition   3,6-diaminoacridinium chloride, ~35%
  3,6-diamino-10-methylacridinium chloride, ~35%
solubility   H2O: soluble0.33 g/mL (lit.)(lit.)
fluorescence   λex 463 nm; λem 490 nm in ethanol
suitability   suitable for fluorescence

Description

Other Notes

DNA fluorochrome. Application in dual fluorescence analysis of cellular DNA and protein simultaneously

Application

Acriflanvine is used for fluorescently labeling of high molecular weight RNA molecules .
Excitation and emission wavelengths in various solvents :
• Methanol: λex = 424 nm; λem = 518 nm
• Ethanol: λex = 426 nm; λem = 524 nm
• Propanol: λex = 430 nm; λem = 512 nm
• Butanol: λex = 430 nm; λem = 526 nm
• Formamide: λex = 434 nm; λem = 524 nm
• Glycerol: λex = 432 nm; λem = 540 nm
• Water: λex = 416 nm; λem = 514 nm

Insoluble in ether, chloroform, and fixed oils. Utilized in fluorescence steady state measurements as a donor molecule (when paired with rhodamine 6G as the acceptor) to function as a pH sensor .

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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