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01810 Sigma

Cycloheximide

≥93.0% (HPLC)

Synonym: 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A

  • CAS Number 66-81-9

  • Empirical Formula (Hill Notation) C15H23NO4

  • Molecular Weight 281.35

  •  Beilstein Registry Number 88868

  •  EC Number 200-636-0

  •  MDL number MFCD00082346

  •  PubChem Substance ID 329747360

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antifungal, Biochemicals and Reagents,
biological source   from synthetic
material   white to light beige
InChI Key   YPHMISFOHDHNIV-FSZOTQKASA-N
assay   ≥93.0% (HPLC)
form   powder
mp   110-118 °C
solubility   H2O: soluble20 mg/mL
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   fungi
  yeast
Gene Information   human ... FKBP1A(2280), PIN1(5300)

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Inhibits protein biosynthesis in eukaryotic cells by binding with the 80S ribosome

Application

CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins, super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques , activate cumulus-free equine oocytes, and to have neuroprotective properties.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN2811 - class 6.1 - PG 2 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany 
3
RTECS 
MA4375000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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