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05130 Sigma

L-Alanine

≥99.0% (NT)

Synonym: (S)-2-Aminopropionic acid, L-α-Aminopropionic acid

  • CAS Number 56-41-7

  • Empirical Formula (Hill Notation) C3H7NO2

  • Molecular Weight 89.09

  •  Beilstein Registry Number 1720248

  •  EC Number 200-273-8

  •  MDL number MFCD00064410

  •  PubChem Substance ID 329747640

  •  eCl@ss 32160406

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Properties

Related Categories Alanine, Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Amino Acids & Derivatives,
InChI Key   QNAYBMKLOCPYGJ-REOHCLBHSA-N
assay   ≥99.0% (NT)
form   powder or crystals
optical activity   [α]20/D +14.0±1°, c = 5% in 5 M HCl
impurities   ≤0.3% foreign amino acids
ign. residue   ≤0.1% (as SO4)
loss   ≤0.1% loss on drying, 110 °C
solubility   H2O: soluble89.1 g/l at 20 degrees c
  diethyl ether: insoluble
  ethanol: soluble (cold 80%)
anion traces   chloride (Cl-): ≤50 mg/kg
  sulfate (SO42-): ≤50 mg/kg
cation traces   Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  NH4+: ≤100 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Zn: ≤5 mg/kg

Description

Other Notes

Preparation of 2-chloropropionic acid; Reduction of derivatives to the aldehyde

Preparation Note

L-Alanine completely dissolves in water at a concentration of 89.1 g/l at 20°C to yield solution. It is also soluble in 80% ethanol and insoluble in ether.

Application

L-Alanine is used as a standard to determine absolute concentration of a protein within a mixture of other proteins measured with SI traceability.

Biochem/physiol Actions

Alanine is a nonessential amino acid that plays a key role in the glucose-alanine cycle between muscle tissue and the liver. In amino acid-degrading tissues such as muscle, amino groups are pooled as glutamate by transamination reactions. The amino group of glutamate is transferred to pyruvate via alanine aminotransferase, forming alanine and α-ketoglutarate. The alanine is passed into the blood and transported to the liver. This reaction is reversed in the liver where pyruvate can be used in gluconeogenesis to form glucose, which may return to other tissues through the circulatory system. Increased alanine levels correlate with higher blood pressure, energy intake, cholesterol levels, and body mass index.

L-alanine has the ability to promote the expression of ferritin and antioxidant stress proteins, heme oxygenase-1 (HO-1).

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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