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06563 Sigma

Methotrexate hydrate

≥99.0% (sum of enantiomers, HPLC)

Synonym: 4-Amino-10-methylfolic acid hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, MTX hydrate, Methylaminopterin hydrate

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Substrate Analogs More...
InChI Key   FPJYMUQSRFJSEW-ZOWNYOTGSA-N
assay   ≥99.0% (sum of enantiomers, HPLC)
optical activity   [α]/D +21.0±2.0°
impurities   ≤0.1% sulfated ash
storage temp.   −20°C

Description

Other Notes

Folic acid antagonist. Potent inhibitor of dihydrofolate reductase.

Application

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.

Price and Availability


Biomedical Applications
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 1544PSN1 6.1 / PGIII
WGK Germany 
3
RTECS 
MA1225000
Protocols & Articles
Peer-Reviewed Papers
15

References

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