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10385 Sigma

Angiotensin III trifluoroacetate salt hydrate

≥98.0% (HPCE)

Synonym: Des-Asp-1-Angiotensin II trifluoroacetate salt hydrate

  • CAS Number 12687-51-3 (free base)

  • Empirical Formula (Hill Notation) C46H66N12O9 · xC2HF3O2 · yH2O

  • Molecular Weight 931.09 (anhydrous free base basis)

  •  Beilstein Registry Number 8385695

  •  MDL number MFCD20264812

  •  PubChem Substance ID 57646800

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Properties

Related Categories AN-AZ, Angiotensins, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
InChI Key   JEOAJMGVSAMVML-UFPGTABSSA-N
assay   ≥98.0% (HPCE)
solubility   H2O: soluble1.0 mg/mL, clear, colorless
storage temp.   −20°C

Description

Amino Acid Sequence

Arg-Val-Tyr-Ile-His-Pro-Phe

Antibody Adsorbant

Arg-Val-Tyr-Ile-His-Pro-Phe-OH.3CH3COOH.4H2O

Biochem/physiol Actions

Angiotensin III is an AT1 and AT2 agonist, with higher sensitivity for the AT2 receptor. Ang III has been shown to be a main effector peptide in RAS-controlled vasopresin release and a stimulator for aldosterone release.

Features and Benefits

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Angiotensin III (Ang III) is a 7-AA bioactive peptide that is formed from the degradation of the Angiotensin II peptide by aminopeptidase A; both are derivatives of angiotensinogen and are components of the renin-angiotensin system (RAS).

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 10385.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

HPLC Analysis of Angiotensins on Discovery® BIO Wide Pore C18

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HPLC Analysis of Angiotensins on Discovery® BIO Wide Pore C8

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HPLC Analysis of Angiotensins on Discovery® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Angiotensins on Discovery® C18
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LC/MS Analysis of Angiotensins on Discovery® BIO Wide Pore C18

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Angiotensins on Discovery® BIO Wide Pore C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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