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10791 Sigma

Antipain

>50000 U/mg

Synonym: [(S)-1-Carboxy-2-phenylethyl]carbamoyl-L-arginyl-L-valyl-argininal

  • CAS Number 37691-11-5

  • Empirical Formula (Hill Notation) C27H44N10O6

  • Molecular Weight 604.70

  •  Beilstein Registry Number 6837629

  •  EC Number 253-631-0

  •  MDL number MFCD00135959

  •  PubChem Substance ID 57646816

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Description

Biochem/physiol Actions

Inhibits serine/cysteine proteases and some trypsin-like proteases. Compare activity to that of leupeptin. Used to evaluate the role of proteases in cell transformations. Used to help identify new proteases.

Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.

Other Notes

Protease inhibitor

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Unit Definition

1 U corresponds to the amount of inhibitor which reduces the trypsin activity by 1 BAEE-U. (1 BAEE-U is the amount of enzyme which increases the absorbance at 253 nm by 0.001 per minute at pH 7.6 and 25°C; BAEE, Cat. No. 12880, as substrate)

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
YV9350700
Protocols & Articles
Peer-Reviewed Papers
15

References

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