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10817 Sigma

Apolipoprotein A-I from human plasma

≥90% (GE)

Synonym: Apo A-1

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Properties

assay   ≥90% (GE)
mol wt   Mr ~28300
solubility   H2O: soluble1 mg/mL, clear, colorless
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... APOA1(335)

Description

Biochem/physiol Actions

High-density lipoproteins are antiatherogenic and cardioprotective by facilitating reverse cholesterol transport (RCT). Some strategies for elevating apolipoprotein A-I levels are studied as therapies for atherosclerosis.

Other Notes

A principal protein component of high-density lipoproteins. Protein - lipid interactions

Preparation Note

lyophilized from 0.01 M ammonium hydrogen carbonate

Application

Apolipoprotein A-I (apoA-I) was used for protecting the heart against vascular disease, it also protects other vascular beds and organs. It was protective against atherosclerosis through its ability to intervene in reverse cholesterol transport.

General description

Apolipoprotein A-I (apoA-I) is the chief protein component of high density lipoproteins (HDL) and a major determinant of HDL structure, composition, and stability. It is an exchangeable apolipoprotein and plays pivotal role in the metabolism of cholesterol.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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