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10820 Sigma

Aprotinin from bovine lung

lyophilized, ~80% (HPCE), crystalline (fine), white, ≥3500 U/mg

Synonym: Trasylol, Trypsin inhibitor (basic)

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Properties

assay   ~80% (HPCE)
form   crystalline (fine)
quality   lyophilized
mol wt   mol wt ~6,500
color   white
solubility   phosphate buffer: soluble5 mg/mL, clear, colorless (PH 7.6 (70 mm phosphate))
storage temp.   2-8°C
Gene Information   cow ... PTI(404172)

Description

Application

Aprotinin is largely used as an inhibitor of trypsin.

Unit Definition

1 U corresponds to 1 biological kallikrein inhibitor unit (KIU)

One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.

Biochem/physiol Actions

Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
YN5080000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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