|Related Categories||Amino Acids, Biochemicals and Reagents, Homoserine Lactones, I - Z, Microbiology,|
Application test: Induces violacein expression in a Chromobacterium violaceum mutant usually not able to produce homoserine lactones.1
N-Octanoyl-DL-homoserine lactone is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) regulate gene expression in gram-negative bacteria, such as Echerichia and Salmonella are involved in quorum sensing, cell to cell communication among bacteria. Some AHLs are potent chemoattractants for human immune cells such as neutrophils.
N-octanoyl-homoserine lactone (N-C8-HSL) is among a group of homoserine lactones that includes; N-Heptanoyl-DL-homoserine lactone (C7HSL), N-Decanoyl-DL-homoserine lactone (N-C10-HSL), N-(3-oxodecanoyl) homoserine-L-lactone (3-oxo-C10 HSL), N-(3-oxododecanoyl)homose
1. Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones. McClean, K.H., et al. Microbiology 143, 3703, (1997)
Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production. Hothersall J, Murphy AC, Iqbal Z, et al. Appl. Microbiol. Biotechnol. 90, 1017-1026, (2011)
The interaction of N-acylhomoserine lactone quorum sensing signaling molecules with biological membranes: implications for inter-kingdom signaling. Davis BM, Jensen R, Williams P, O'Shea P. PLoS ONE 5, e13522, (2010)
Nodulation-gene-inducing flavonoids increase overall production of autoinducers and expression of N-acyl homoserine lactone synthesis genes in rhizobia. Pérez-Montaño F, Guasch-Vidal B, et al. Res. Microbiol. 162, 715-723, (2011)
N-Acylhomoserine lactones are potent neutrophil chemoattractants that act via calcium mobilization and actin remodeling. Karlsson T, Musse F, Magnusson KE, Vikström E. J. Leukoc. Biol. 91(1), 15-26, (2012)
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