|Related Categories||Biochemicals and Reagents, Chemical Biology, Chemical Synthesis, Conjugation Chemistry: Azides, Alkynes and Other Reagents, Nucleoside Analogs,|
2′-Azido-2′-deoxyuridine (N3-dU) upon phosphorylation to 2′-azido-2′-deoxyuridine 5′-diphosphate (N3dUDP) becomes a mechanistic inhibitor of bacterial ribonucleoside diphosphate reductase (RDPR). N3-dU has recently been evaluated for its potential use as a sensitive multi-spectroscopic probe for nucleic acids
Products of the inactivation of ribonucleoside diphosphate reductase from Escherichia coli with 2′-azido-2′-deoxyuridine 5′-diphosphate. Salowe SP, Ator MA, Stubbe J. Biochemistry 26, 3408-3416, (1987)
Alternative model for mechanism-based inhibition of Escherichia coli ribonucleotide reductase by 2′-azido-2′-deoxyuridine 5′-diphosphate. Salowe S, Bollinger JM Jr, Ator M, et al. Biochemistry 32, 12749-12760, (1993)
Chemical synthesis of site-specifically 2'-azido-modified RNA and potential applications for bioconjugation and RNA interference. Aigner M, Hartl M, Fauster K, et al. ChemBioChem. 12(1), 47-51, (2011)
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