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11707 Sigma

Bafilomycin B1 from Streptomyces sp.

≥80% (HPLC)

  • CAS Number 88899-56-3

  • Empirical Formula (Hill Notation) C44H65NO13

  • Molecular Weight 815.99

  •  Beilstein Registry Number 4640118

  •  PubChem Substance ID 329749534

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
InChI Key   KFUFLYSBMNNJTF-HHZDOKBSSA-N
assay   ≥80% (HPLC)
form   powder
color   faintly yellow
Mode of action   enzyme | inhibits
antibiotic activity spectrum   Gram-positive bacteria
  fungi
shipped in   wet ice
storage temp.   −20°C

Description

Packaging

1MG

Warning

Fatal if swallowed.
Bafilomycin B1 is fatal if it is inhaled, swallowed, or if it comes in contact with skin.

Application

Bafilomycin B1 is a toxic macrolide antibiotic used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis .

Biochem/physiol Actions

Bafilomycin B1 inhibits vacuolar type H+-ATPase (V-ATPase) and is used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis.

Bafilomycin B1 inhibits vacuolar type H+-ATPase (V-ATPase). Bafilomycin B1′s activity results from the presence of a large macrocyclic lactone ring to which deoxy sugars may attach.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Moisture sensitive. Keep in a dry place.

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3462 6.1 / PGI
WGK Germany 
3
RTECS 
NG8841000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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