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  • 11707 - Bafilomycin B1 from Streptomyces sp.

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11707 Sigma

Bafilomycin B1 from Streptomyces sp.

≥80% (HPLC)

  • CAS Number 88899-56-3

  • Empirical Formula (Hill Notation) C44H65NO13

  • Molecular Weight 815.99

  •  Beilstein Registry Number 4640118

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
InChI Key   KFUFLYSBMNNJTF-HHZDOKBSSA-N
assay   ≥80% (HPLC)
Mode of action   enzyme | inhibits
antibiotic activity spectrum   Gram-positive bacteria
  fungi
shipped in   wet ice
storage temp.   −20°C

Description

Warning

Fatal if swallowed.
Bafilomycin B1 is fatal if it is inhaled, swallowed, or if it comes in contact with skin.

Application

Bafilomycin B1 is a toxic macrolide antibiotic used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis .

Biochem/physiol Actions

Bafilomycin B1 inhibits vacuolar type H+-ATPase (V-ATPase) and is used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis.

Bafilomycin B1 inhibits vacuolar type H+-ATPase (V-ATPase). Bafilomycin B1′s activity results from the presence of a large macrocyclic lactone ring to which deoxy sugars may attach.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3462 6.1 / PGI
WGK Germany 
3
RTECS 
NG8841000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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