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13752 Sigma

Penicillin G sodium salt

≥98.0% (N)

Synonym: Benzylpenicillin sodium salt

  • CAS Number 69-57-8

  • Empirical Formula (Hill Notation) C16H17N2NaO4S

  • Molecular Weight 356.37

  •  Beilstein Registry Number 3834217

  •  EC Number 200-710-2

  •  MDL number MFCD00069666

  •  PubChem Substance ID 329750324

  •  eCl@ss 34010400

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Biochemicals and Reagents,
InChI Key   FCPVYOBCFFNJFS-LQDWTQKMSA-M
assay   ≥98.0% (N)
form   crystalline
optical activity   [α]25/D +285 to 310°, c = 2% in H2O
mol wt   mol wt 356.37 g/mol
composition   Carbon, 53.88%
  Hydrogen, 4.81%
  Nitrogen, 7.83%
pH   5.5-7.5 (3% in H2O)
solubility   H2O: soluble0.1 g/mL, clear, colorless
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Biochem/physiol Actions

Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.

Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.

Caution

Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days. The sodium salt is soluble in H2O at 100 mg/mL.

Application

Penicillin G has been used to study penicillin-binding protein 2, and non-toxigenic Corynebacterium diphtheriae isolated from cases of pharyngitis.

General description

Penicillin G is a narrow spectrum natural antibiotic. It is effective against Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus.

Price and Availability

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
XH9800000
Protocols & Articles

Articles

Inhibition of Cell Wall Biosynthesis by Antibiotics

Antibiotics are molecules that specifically target and kill cells. The term antibiotic is frequently used interchangeably with the word antibacterial, but antiviral, antifungal and antineoplastic com...
BioFiles 2006, 1.4, 7.
Keywords: Antibiotics, Antifungals, Antivirals, Building blocks, Glycosylations, Metabolism

Peer-Reviewed Papers
15

References

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